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Biomedical subjects

V P Poshivalov

Publications and source records attributed to V P Poshivalov.

At least 19 recordsLinked to original sources
PubMed1989

[Effect of opiate receptor agonists and antagonists on maternal aggression in rats].

The behavioral effects of opiate agonists and antagonists were studied on the female aggression model. Mu-agonist buprenorphine more selectively decreased maternal aggression than kappa-agonist tifluadom. Kappa-agonists (bremazocine, tifluadom) increased passive defence in lactating female rats. Ethopharmacological data shows predominant involvement of brain mu-opiate receptor system in the integrative processes of maternal behavior and maternal aggression in particular.

Aggression↗
PubMed1987

[Pharmacoethological analysis of the effects of thyroliberin and melanostatin in a model of anxious-defensive behavior in mice].

Psychotropic properties of thyroliberin and melanostatin were studied on the model of timid-defensive behaviour of mice. Oligopeptides increased defensive behaviour and timidity, and decreased intraspecies sociability. GABA deficiency and dopaminergic system blockade increased timid-defensive behaviour of mice. Mobilizing activity of peptides on the agonistic behaviour (aggression and defense) may be explained by their anxiogenic properties.

Aggression↗
PubMed1987

[Independent benzodiazepine and beta-carboline binding sites in the brain of aggressive and anxious-defensive mice].

Distribution of specific 3H-flunitrazepam and 3H-beta-carboline-3-carboxylate binding sites in the brain regions of aggressive and timid-defensive mice was investigated before and after subchronic injection of diazepam (5 mg/kg). The absence of differences between the affinity and concentration of 3H-flunitrazepam binding sites in diencephalon and brain cortex in aggressive and defensive mice may be explained by general benzodiazepine receptor reaction on isolation and agonistic interaction stress. Significant predominance of 3H-beta-carboline-3-carboxylate binding sites in the brain cortex, as compared to the concentration of 3H-flunitrazepam binding sites suggests the presence of specific binding sites for beta-carbolines, which have specific distribution in the brain.

Aggression↗
PubMed1987

[Psychopathological and hormonal manifestations of alcoholic intoxication and emotional stress in monkeys].

Ethological approach to studying mature P. hamadryas and M. mulatta males has revealed a wide spectrum of changes in individual and zoosocial behaviour in response to the administration of different alcohol doses and stress stimuli. It has been established that neuroendocrine basis for the depression of psychic and locomotor activities developing in conditions of alcohol intoxication and emotional stress is an extremely high release of catecholamines and the increase of glucocorticoid secretion accompanied by a sharp decrease in androgen products. It should be noted that the exposure to stress stimuli during consumption of small alcohol doses intensifies depression-like stress-induced behaviour of monkeys.

Alcoholic Intoxication↗
PubMed1987

[Intraspecies animal behavior in a model of experimental cerebral ischemia].

Specifics of intraspecies behaviour following ligation of both or either one of the two carotid arteries, were studied in rats. Certain behavioural features are altered in different ways depending on ligation of the right or left carotid artery. The approach can be applied to evaluation of graveness of the brain ischemic lesion.

Aggression↗
PubMed1986

Pharmaco-ethological analysis of antidepressant drug effects.

An ethological approach to the analysis of antidepressant drug action focuses on the restorative effects of these drugs on intraspecies behavior and locomotor activity. The present analysis reveals that iprazid and amphetamine differentially alter locomotion and intraspecies behavior in mice that were pretreated with reserpine. Fluoxetine restores intraspecies behavior, specifically by increasing the number of passive contacts, but without activating locomotion. Trazodon, pyrazidol and clomipramine restore aggression by dominant mice that was suppressed by aversive stimulation. The restoration of intraspecies behavior among laboratory rodents subjected either to reserpine treatment or to prolonged aversive stimulation may reveal the antidepressant effects of drugs.

Aggression↗
PubMed1985

[Pharmacoethological analysis of the action of beta-carbolines].

The ethological spectrum of four beta-carbolines was studied for intraspecific aggression, sociability integration and individual behavior. It was established that beta-carboline-3-carboxyethyl ether given at subconvulsant doses increases aggression, lowers sociability as a diazepam antagonist. Diazepam reduces aggression and increases sociability. It is suggested that benzodiazepine receptors are involved in the integration of interspecific sociability and aggressive behavior of the "attack" type. Aggression of the defence type has no inhibitory beta-carboline control (1-methyl-6-methoxy-dihydro-beta-carboline). The differences in the ethological spectra of beta-carbolines have been demonstrated.

Aggression↗
PubMed1981

Pharmaco-ethological analysis of social behaviour of isolated mice.

The ethological profile of some neuropharmacological substances affecting catecholamines, serotonin and GABA was investigated in isolated mice. Changes in brain noradrenergic, dopaminergic or serotonergic systems, in addition to a block of the inhibitory GABA system, caused "irrepressible" aggression and a lack of sociability in isolated mice. GABA analogues (phenibut, phenylpyrrolidon) and GABA agonists reduce aggression and increase intraspecies sociability; small doses of GABA antagonists (picrotoxin, bicuculline) exert the opposite effect. GABA may play a key part in the control of aggression and sociability in isolated animals. Selective activation of intraspecies sociability with a concurrent reduction of species-specific aggression requires complex pharmacological action.

Animals↗
PubMed1981

[GABA-ergic correlates of aggression and intraspecies sociability of mice subjected to isolation].

Experiments on isolated mice (CC57W males) have demonstrated that GABA antagonists (bicuculline, picrotoxin, thiosemicarbazide) increase the desocializing effects of isolation (enhance aggression and reduce intraspecies sociability), while GABA-positive drugs (muscimol, gamma-acetylenic GABA) within a certain dosage range diminish aggression and favour a temporary recovery of sociability. It is suggested that GABA deficiency in the CNS of isolated mice is a pathogenetic link responsible for the pathological behavior -- superaggression and hyper-reactivity.

Aggression↗
PubMed1980

The integrity of the social hierarchy in mice following administration of psychotropic drugs.

1 Mice in small groups develop a despotic type of social hierarchy, a feature of which is to resist alteration through the medium of psychotropic drugs. This makes a rapid pharmacologically induced change in the social hierarchy impossible. 2 Patrolling the territory and a certain level of social interaction are both critical factors in maintaining the phenomenon of inertia in the social hierarchy. Psychotropic drugs (diazepam, droperidol and mescaline) altered both these factors to a varying degree and also displayed a differing ability to maintain the inertia of the social hierarchy. 3 A drug-induced alteration in the level of aggression in a subordinate mouse in a group of three does not cause an alteration in its social position. 4 Chronic administration of diazepam, droperidol or mescaline, all of which alter the level of aggression in different ways, can result in an inversion of the social hierarchy where a competitive rival is present in the group of mice. The rate of inversion of the social hierarchy depends on the type of pre-existing social hierarchy. 5 It is suggested that the ability of psychotropic drugs to maintain the inertia of the hierarchy be used as an index of their effect upon certain types of species-specific behaviour; in particular aggression.

Aggression↗
PubMed1979

[Analysis of the effect of phenamine, L-DOPA and parachlorophenylalanine on the zoo-social behavior of isolated mice].

Abnormal changes in the structure of the individual and zoo-social behaviour of isolated mice due to phenamine (amphethamine), L-DOPA or PCPA were shown. Several elements of the "pathological syndrome of isolation" in mice were found to increase under the action of the drugs studied. The extension or reduction of contacts between animals of the same species was used as an integrative indicator of recovering (resocializing) or aggravating (desocializing) effect of psychotropic drugs on the pathology of animal behaviour.

Amphetamine↗