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Biomedical subjects

V P Shishkov

Publications and source records attributed to V P Shishkov.

At least 19 recordsLinked to original sources
PubMed1989

[Electron microscopic, serological and hematological research on lambs infected with the bovine leukemia virus].

A complex study on experimental oncornavirus infection in sheep was carried out. Fast development of infectious process, production of virus-specific precipitating antibodies, presence of BLV reproduction in cultivated leucocytes were found. Terms of antibody appearance ranged between 20-30 days after infection. Stable antibody carriage remained during the whole observation period (36 months). Moreover, no expressed specific changes were observed in the hemogram of tested animals. Use of electron microscopy in oncornavirus infection allows revealing cells with pathologic changes in organelles and nucleus which are characteristic of the leucosis.

Animals↗
PubMed1989

[Ultrastructural characteristics of virus-producing lymphocytes in bovine leukemia].

The ultrastructure of peripheral lymphocytes and lymph was examined in 35 head of cattle in health and chronic lymphoid leukemia. In the latter, ultrastructural alterations were detected in the nuclei and cytoplasmic organelles. The alterations appeared as Golgi apparatus hypertrophy, mitochondrial polymorphism, myelinoid formations. There were nuclear pockets, invaginations in the nuclei of leukemic lymphocytes. A correlation was established between the number of cells having nuclear pockets and the virus production of lymphoid cells in chronic lymphoid leukemia. There is evidence that the existence of nuclear pockets along with other indicators may be useful in assessing the development of leukemias in cattle. The morphogenesis of bovine leukemia virus is presented.

Animals↗