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Biomedical subjects

V P Tiurin

Publications and source records attributed to V P Tiurin.

At least 19 recordsLinked to original sources
PubMed2006

[Infective endocarditis in patients on program hemodyalisis].

Ten (1.8%) out of 558 patients with end-stage chronic renal failure on program hemodialysis developed infective endocarditis (IE). The average length of hemodialysis before IE was 17.0 +/- 14.5 months. The main cause of IE was infection of the site of vascular approaches. The diagnosis was difficult; Duke criteria modified by J. Li et al. (2000) allowed evidenced diagnosis of IE only in 30% of cases, while modified criteria offered by the authors did it in 50% of cases. The article discusses rational antibacterial therapy. Hospital lethality in IE is as high as 50%.

Adolescent↗
PubMed2002

[Neurological complications of infectious endocarditis].

Of 204 patients with infectious endocarditis (IE) treated in the hospital in 1980-2000, 43(21.2%) developed neurological complications. These were: ischemic stroke (72.1%), hemorrhagic stroke (9.3%), both (7%), abscess and subarachnoidal hemorrhage (2.3% for each), meningitis (7%), toxic encephalopathy (11.6%). Neurological complications of IE arose prior to treatment and within the first week of antibacterial therapy in 63% cases, more frequently in the left carotid territory. Neurological complications in IE debute manifested acutely, pareses were more frequent than paralyses, with elevated temperature, low hemoglobin and red cell levels, leukocytosis. MRT detected 8 +/- 4.6 foci in the brain, CT--2 +/- 1.1, on the average. Lethality of IE patients with neurological complications reached 58.1% and was significantly higher than in those without such complications (14.9%, p < 0.001). Overall acturial survival 1 year after the discharge from the hospital was 94.4%, 5-year survival--61.1%, 10-year survival--11%.

Adolescent↗
PubMed2002

[Urgent problems of medical aid in infectious endocarditis].

The authors analyze the incidence of infectious endocarditis (IE), the influence of diagnostic time on the lethality, the significance of surgical treatment. The main ways of further improvement of IE patient therapy are defined. They include the training of medical staff, centralization of the patients in the military medical institutions of the center by transfer from the districts after making the diagnosis in order to conduct the adequate medicamentous and appropriate surgical treatment.

Anti-Bacterial Agents↗
PubMed2000

[Glucocorticosteroids in bacterial endocarditis: is it beneficial or harmful?].

AIM: Analysis of results of treatment of infectious endocarditis (IE) with glucocorticosteroids in combination with antibiotics. MATERIAL AND METHODS: 128 IE patients received antibiotics (control group). Glucocorticosteroids were added to antibiotics in 44 IE patients (study group). RESULTS: Valvular replacement, congestive heart insufficiency, thromboembolic complications, suppression of cellular and humoral immunity occurred more frequently in patients of the study group. CONCLUSION: It was found that glucocorticosteroids affect IE negatively, especially in the dose 30 mg/day and higher. Glucocorticosteroids are indicated in allergic reactions to the antibacterial drugs, severe renal damage (proteinuria < 1 g/l), myocardial defects; contraindicated in non-eradicated IE causative agent, in recurrent IE.

Adolescent↗
PubMed2000

[The use of plasmathrombocytapheresis in the combined treatment of rheumatoid arthritis].

One of the possible ways to correct platelet hemostasis in active rheumatoid arthritis (RA) is inclusion of plasmathrombocytapheresis (PTCA) into complex therapy. This operation is pathogenically approved in changes of platelet morphofunctional state. To perform PTCA it is possible to use the blood fractionator BF-3.5. PTCA represents the transfusiologic operation consisted of premedication, vascular approach, hemodilution, blood stabilization and the main part of operation. The positive effect during the PTCA use according to our program was achieved in 93 +/- 2% of the cases. PTCA can be considered as the procedure of choice in complex therapy of RA patients with disorders in platelet chain of hemostasis that permits to decrease rapidly the disease activity and to reduce the period of patient hospital treatment.

Antirheumatic Agents↗
PubMed1999

[Transesophageal echocardiography in diagnosis of infectious endocarditis].

Transthoracic and transesophagal echocardiography (TT EChG and TE EChG) were performed in 43 patients with infectious endocarditis (IE). Sensitivity and specificity of TE EChG in detection of vegetations were higher (92 and 75%, 81 and 50% for TE EChG and TT EChG, respectively). Vegetations and thromboembolism were unrelated. With TE EChG, morphologically verified perforations of valvular cusps were revealed 3 times more frequently than with TT EChG. Along with detection of vegetations and dysfunction of the prosthetic valve, an essential diagnostic marker of IE of the artificial valve is visualization of paraprosthetic fistulas in 2 of 5 patients. Indications for TT and TE EChG and techniques of their performance are described. TT EChG is used in screening for IE. TE EChG is conducted in complications of IE.

Adolescent↗
PubMed1998

[The current course and treatment of infectious endocarditis].

Clinical study of 172 patients treated in the Burdenko Military Hospital for subacute infectious endocarditis in 1980-1996 compared with 192 cases in 1950-1979. Contemporary course of the disease is attended by a few symptoms, primordiality and single-valve affection. On the grounds of antibiotics sensitivity of the most prevalent infection agents discovered in 1996, the article develops some schemes of antibacterial therapy for Streptococcus, Enterococcus and staphylococcal etiology of disease. Rational antibiotic therapy together with surgery measures reduced lethality to 14.3% for Streptococcus endocarditis, to 16.7%--for Enterococcus and to 34.4%--for Staphylococcus.

Adolescent↗