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Biomedical subjects

V P Uzhva

Publications and source records attributed to V P Uzhva.

At least 19 recordsLinked to original sources

[Acute postop ischemic hepatitis and hypotension].

The significance of the pronounced durable systemic arterial hypotension (SAH) in the origin of an acute postoperative ischemic hepatitis (APIH) was established, basing on the analysis of 40 clinical observations. Its occurrence is promoted by hemorrhage with 30% and more the circulating blood volume (CBV) deficiency, chronic cardiovascular system and pulmonary diseases, liver cirrhosis, shock, massive infusions of the blood and its components, the abdominal aorta atherosclerosis with stenosis of tr. coeliacus, a. hepatica. Forgoing SAH, the presence of promoting factors, jaundice, the transpherase activity raising in 3-5 times, the level of blood coagulating factors reduction, stable intestinal paresis were diagnostically significant symptoms. Experimental model of an APIH was elaborated in dogs, which occurs due to hypotension, caused by CBV reduction by 40% during two hours. The refractoriness of a. hepatica propria to the blood reinfusion was established. In the APIH occurrence threat the perftoran application in the 20 ml/kg dosage is the prophylaxis method as well as the method of the curative tactics choice.

Acute Disease↗

[Acute postoperative pancreatitis and hypertension of the pancreatic vascular system during hemorrhage in the course of the experiment].

It was established in experiments on dogs that the arterial pressure decompensation in intraorganic pancreatic gland (PG) vessels and of the tissue blood flow also occurs in 40% deficiency of the blood circulating volume and in systemic arterial hypotension (SAH) in a. femoralis. Experimental model of an acute postoperative pancreatitis (APP) and of the PG necrosis was elaborated. Application of perftoran in 20 ml/kg dosage had promoted the APP and the non-reversible ischemic nonocclusive PG damage occurrence and prophylaxis. In SAH combined with retentia of caudal branch of a. lienalis the PG necrosis occurs.

Acute Disease↗

[Ogilvie's syndrome in surgical patients].

On the basis of the analysis of observation of 24 patients, the causes and mechanisms of the Ogilvie syndrome development after the operation were studied. The incidence of occurrence of the syndrome in 1615 patients with acute ileus has been established. Its clinical forms, methods for diagnosis and treatment were studied.

Acute Disease↗

[Nodular goiter from the oncologic viewpoint].

Experience in the diagnosis and treatment of nodular forms of thyroid carcinoma is generalized. Among 4,601 patients who underwent operation for nodular goiter 338 (7.3%) were found to have carcinoma. Aspiration biopsy was widely used in establishing the diagnosis and chromothyrolymphography during the operation. The method of operative treatment consists in extrafascial resection of the thyroid gland and subsequent substitution therapy with thyroidine or thyrotoxine.

Adolescent↗

[Surgical methods in the treatment of nodular goiter].

The experience with surgical treatment of 4476 patients with a nodular form of goiter has been summarized. Of them, in 2684 the solitary nodes were revealed, in 1359--the multiple ones, in 433--the mixed ones. Operative intervention was performed with regard for spreading of the thyroid gland lesion: from sparing resection to total thyroidectomy with transplantation of a graft under superficial fascia of chest.

Adolescent↗

[Acute hepatorenal failure as a component of multiorgan failure syndrome in patients after surgical intervention].

The etiology, pathogenesis, clinical features of acute postoperative hepatorenal failure (APHRF) in 50 surgical patients were studied. APHRF was considered as a component of the multiorgan insufficiency syndrome. The general somatic factors contributing to APHRF development were established: chronic pathology of the liver and kidneys, chronic cardiogenic pathology, hypertension. The risk factors for APHRF development before, at operation and at the nearest period after it were distinguished: shock, hemorrhage, massive transfusion of blood, or its components, hypoxia, systemic arterial hypotension. The attention is attracted to the significance of combination of the systemic arterial hypotension with the contributing general somatic factors and risk factors before, at operation and at the nearest period after it in APHRF development.

Acute Disease↗

[Effect of sodium nitroprusside on blood pressure in extra-organic blood vessels of the liver and kidney].

Under conditions of acute experiment with the use of sodium nitroprusside on 32 mongrel dogs, it was established that decrease in the mean systemic arterial pressure (MSAP) by 25.5% didn't lead to statistically significant decrease in the renal arterial pressure. At the same time, the maximum hepatic arterial pressure decreased by 25.2%, the minimal--by 13%. Decrease in the pulse hepatic arterial pressure forestalls that in the renal arterial pressure in deepening of hypotension. Pulse hepatic and renal arterial pressure disappeared in MSAP equal to (4.41 +/- 0.05) kPa, or (33.1 +/- 0.4) mm of Hg.

Animals↗

[Nodular forms of goiter as a cause of cancer of the thyroid gland].

The experience with diagnosis and treatment of struma maligna in 267 (5.5%) of the 4876 patients operated on for nodular forms of goiter is summarized. In the diagnosis, the puncture biopsy was widely used. Extrafascial resection of the thyroid gland with subsequent replacement therapy with thyroidin is a method of choice.

Adolescent↗