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Biomedical subjects

V P deLuise

Publications and source records attributed to V P deLuise.

15 recordsLinked to original sources

Stromal keratitis with anterior membrane dystrophy.

Anterior stromal nummular infiltrates developed in a 55-year-old woman with recurrent corneal erosion syndrome and associated anterior basement-membrane dystrophy. Gram and Giemsa stains showed no organisms, and cultures revealed no growth at 72 hours. Stromal keratitis can complicate recurrent corneal erosions associated with anterior basement-membrane dystrophy.

Basement Membrane↗

Quantitation of tear lysozyme levels in dry-eye disorders.

A simple, rapid, reproducible method of quantifying tear lysozyme levels with a dual-channel spectrophotometer was used to compare normal subjects and those with dry-eye syndrome. The method was sensitive (80%) and specific (85%) and had a predictive value of a positive result of 83%. One patient with clinical manifestations of dry-eye syndrome and paradoxically elevated levels of tear lysozyme was found to have underlying sarcoidosis.

Humans↗

Smooth muscle tumors of the testicular adnexa.

One of 3 patients with peiomyosarcomas of the epididymis and spermatic cord treated by inguinal orchietomy was cured, 1 died 18 months after diagnosis and 1 was living but had a pulmonary metastasis 4 years after excision of the primary tumor. All 3 patients with leiomyoma of the testicular adnexa were cured. The literature concerning smooth muscle tumors of the adnexa is reviewed.

Aged↗

Primary infantile glaucoma (congenital glaucoma).

Primary infantile glaucoma, commonly termed congenital glaucoma or trabeculodysgenesis, is an unusual, inherited connatal anomaly of the trabecular meshwork and anterior chamber angle which leads to obstruction of aqueous outflow, increased intraocular pressure, and optic nerve damage. Its pathogenesis is still disputed; most observers have not been able to document ultrastructurally a continuous endothelial membrane, as initially advanced by Barkan. Medical therapy for primary infantile glaucoma is accorded a supportive role; the primary, definitive treatment is surgical. Both goniotomy and trabeculotomy ab externo give similarly good results in the majority of patients. The prognosis in this disease is related to the time of its initial presentation, initial surgical intervention, degree of optic nerve damage, nature and quality of corneal enlargement and astigmatism, progressive refractive error, and anisometropic amblyopia. The inability to easily quantitate visual acuity and extent of visual loss in neonates makes these parameters less helpful in following patients than measurement of corneal diameter and intraocular pressure. However, even these data should not be relied upon exclusively to determine the quality or quantity of success in primary infantile glaucoma.

Anterior Chamber↗

Ocular involvement in the respiratory vasculitides.

The respiratory vasculitides are idiopathic inflammatory syndromes, characteristically involving the pulmonary vasculature as well as that of several other organ systems. The inflammatory response in these diseases is uniformly granulomatous. There are three distinct, recognized respiratory vasculitides: Wegener's granulomatosis, Churg-Strauss syndrome (allergic granulomatosis and angiitis), and lymphomatoid granulomatosis. Each of these entities may have ophthalmic manifestations, and ocular involvement may, in fact, be the presenting sign. The systemic and ocular manifestations, as well as the differential diagnosis and management of each of these entities are discussed.

Adrenal Cortex Hormones↗