Biomedical subjects

V Pancholi

Publications and source records attributed to V Pancholi.

27 records · Page 2Linked to original sources

PubMed1985

Protective immunity to systemic nocardiosis in mice immunized with cell extract antigens of Nocardia asteroides.

Mice immunized with crude cell extract antigens of Nocardia asteroides as well as its purified fraction F1 elicited significant levels of both humoral and cellular immune responses. These animals when challenged with 50% lethal dose of N. asteroides, two weeks after the complete immunization exhibited significant protection as seen by decreased mortality and viable counts compared to nonimmunized. The immunized animals were capable of clearing the infection much faster as compared to control. Cell extract antigens which were mainly protein in nature are thought to have a prime role in prevention and restriction of nocardial infection.

Animals↗

PubMed1985

Experimentally induced subcutaneous infection by black pigmented Bacteroides species in rats.

In a rat model of anaerobic subcutaneous abscess developed to study the pathogenicity of pure cultures of black pigmented Bacteroides sp. (Bacteroides melaninogenicus and Bacteroides intermedius) maximum lesions were seen between 7 and 15 days after inoculation. Abscesses were produced by one type strain each of B. melaninogenicus and B. intermedius and by 20 of 25 clinical isolates of black pigmented Bacteroides species.

Abscess↗

PubMed1985

Immune responses to the protein, carbohydrate and lipid antigens of Nocardia asteroides in experimental nocardiosis in mice.

The intravenous injection of Nocardia asteroides into mice produced systemic nocardiosis involving all the vital organs. Infection of the kidneys and adrenals was more persistent and progressive than in other organs as evidenced by increased bacterial counts and histopathological findings. During the course of the experimental infection, no humoral immune response was detected against various protein antigens up to 4 weeks after challenge, but significant cell-mediated immunity (CMI) was found. Phospholipid antigens elicited only a humoral immune response. The increased CMI responses with protein antigens correlated well with the decreasing bacterial load, which suggested that CMI against proteins was important in the pathogenesis of this disease.

Animals↗

PubMed1985

Immunological responses to protein, carbohydrate and lipid fractions of Nocardia asteroides in mice.

The protein, polysaccharide and phospholipid constituents of Nocardia asteroides have been partially purified and their immunogenicity studied in mice. Humoral and cellular immune responses were demonstrated against a crude cytoplasmic protein fraction (CPF). Two fractions of CPF were prepared on a Sephadex G-200 column; a high mol. wt fraction, fraction-1(F1) was capable of eliciting both types of immune responses, whereas fraction-2(F2) behaved more like a hapten. Phosphatides elicited only humoral responses whereas polysaccharides were non-immunogenic.

Animals↗

PubMed1984