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Biomedical subjects

V Paoletti

Publications and source records attributed to V Paoletti.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Nephrotoxicity of drugs].

Setting out from the high prevalence of iatrogenic toxic effects on the kidney, the authors examine the pathophysiological mechanisms underlying this toxicity, and suggest their classification. The principal pathophysiologic and clinical models of the action of various groups of drugs responsible for these effects are discussed.

Acute Disease↗
PubMed1994

[Drug-induced lung diseases].

In the light of recent fresh reports of drug-induced lung lesions, the authors suggest an updated classification of these based on data found in the literature. Special attention has been reserved to the pathogenetic mechanisms underlying specific clinical pictures.

Adult↗
PubMed1990

[Pericardial effusions as the initial manifestation of extracardiac tumors. A discussion of 2 cases and a review of the literature].

The authors describe two cases of cardiac tamponade that were the first manifestation of an extracardiac tumor; they stress that this type of presentation described in the literature as an extremely rare occurrence, has become more frequent in recent years as a result of both a higher prevalence in absolute terms and of a more reliable detection thanks to the availability of more sensitive and more practicable diagnostic techniques. Having briefly described the pathophysiology of pericardial effusions with special reference to those of neoplastic origin, the authors detail the most sensitive tools for a correct diagnosis.

Adenocarcinoma↗
PubMed1989

[Illnesses associated with high environmental temperature].

After a brief review of pathologies secondary to high environmental temperatures and of the pathophysiological mechanisms underlying different clinical patterns the authors stress the need for a more precise knowledge of the risk factors involved and detail suitable preventive measures. They also describe the situation which occurred in Rome during the 1983 heat wave during which a steep increase in mortality was observed compared to preceding years.

Adaptation, Physiological↗
PubMed1989

[Drugs and food].

The authors examine the complex relationships between drugs and foodstuffs from the various points of view of clinical pharmacology, toxicology, and nutritional science. Special attention is concentrated on the possible interference of foodstuff with drug bioavailability, changes of drug bioavailability during malnutrition, drug-induced changes of nutritional status, and incompatibility between foodstuffs and drugs.

Biological Availability↗
PubMed1989

[Efficacy and tolerability of captopril-hydrochlorothiazide vs amiloride-hydrochlorothiazide combination in mild to moderate arterial hypertension].

Forty patients, mean age 56.87 yrs. with light or moderate essential arterial hypertension were randomized double-blind into two subgroups of 20 subjects each, and submitted to daily combined drug treatment with either captopril 50 mg + hydrochlorothiazide 25 mg (group A) or amiloride 5 mg + hydrochlorothiazide 50 mg (group B). Patients were monitored after the washout period and after 4 and 8 weeks of treatment approximately 20-24 after the last dose. The following parameters were studied: blood pressure, heart rate, body weight, untoward side effects. Standard laboratory tests were performed in all patients after washout and at the end of the 8-week treatment period. Both combinations significantly reduced pressure values but the captopril-hydrochlorothiazide combination reduced blood pressure more readily and proved more effective in reducing diastolic values. There were no dropouts due to subjective side effects which were of little relevance and were equally distributed among the two groups. As for laboratory data, patients taking the captopril-hydrochlorothiazide combination had a statistically significant increase in blood glucose. Neither combination induced significant changes in the other parameters, especially as far as potassemia was concerned.

Aged↗
PubMed1989

[Netilmicin in the treatment of infections of the lower urinary tract].

The authors treated 30 patients (11 females and 19 males) with cystitis or cystopyelitis. Patients were randomly assigned to one of the following treatments: a) netilmicin 200 mg daily, b) netilmicin 200 mg + ampicillin 1 g daily. Clinical and bacteriologic results were positive in all cases with resolution of clinical signs of infection and negative cultures at the end of treatment. Netilmicin alone yielded the same results as its combination with ampicillin. The safety, monitored also with netilmicin serum levels, was always good.

Aged↗