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Biomedical subjects

V Pazderka

Publications and source records attributed to V Pazderka.

At least 19 recordsLinked to original sources
PubMed1989

Radiological picture of juvenile rheumatoid arthritis.

Basing on the results of radiological, clinical and laboratory examinations of 200 children with juvenile rheumatoid arthritis, we tried to obtain a comprehensive picture of radiological changes in the joints, the spine and the remaining skeleton caused by JRA. The bulk of data was obtained in the period between 1954 and 1972, but for some of the patients, our follow-up continued until 1987. Our main interest were differences in morphological changes caused by JRA and adult RA. We described initial changes and their progress in childhood, adolescence and adulthood, drawing attention to fundamental differences in radiological changes and their progress in patients with an onset of disease in the first half of childhood (up to the age of 8) and in those with an onset in the second half of childhood, where these changes were similar already to those caused by adult RA. Juvenile rheumatoid arthritis affects mainly skeletal growth by either retarding or accelerating various ossification processes. The skeleton of children has a great regenerative capacity, but this, on the other hand, supports various disturbances of growth brought forth by disease. This, apparently, account for differences of changes in the skeleton of the joints observed in JRA patients during childhood and adulthood. Whenever a case is suspected of JRA, a radiological examination of the joints involved ought to be complemented by a radiological examination of the hands because most of our radiographs showed structural changes in the hands. Particular attention should also be given to the knees and hips of children with active disease over a period of 3-6 years. Synostosis of arches and joints of the cervical spine, a typical feature of JRA, was observed in 20-25% of former JRA patients. Synostoses occurred either in the individual segments or in the whole cervical spine, but were never absent at the level of vertebral bodies C2-C3. There were neither objective nor subjective complaints.

Adolescent↗
PubMed1989

[Degenerative changes in intervertebral disks].

A histotopographic study of lumbar spine was made in 27 deceased of the age of 2 to 85 years lacking of any spinal clinical symptomatology. Regressive changes were found in all the intervertebral disks except in infants. A central necrosis was present in 26 cases and pericentral striped necrosis in 19 cases. Other disks showed consequences of necrosis--vascularization, scarring, regenerative proliferation of chondrocytes, ganglion type cavities. A concept of disk lesion as a trigger of further spinal lesions was supported by frequent regressive changes of the disks. Schmorl's (internal) nodes were found in 35 cases, quite often in young persons without clinical symptomatology. The amount of glycosaminoglycans during the disk regression was detected by Safranin O-Fast Green stain with ambiguous results. A hypothetical spontaneous vanishing of the nucleus pulposus in accordance with the age was a topic of discussion. Protrusions of the disks into the spinal canal were not found. Initial osteophytes at ventral margins of vertebral bodies were identified in 49 cases, at dorsal margins in only 3 cases.

Adolescent↗
PubMed1985

Enthesopathy of the hip joint.

Morphologically, enthesopathy appears as dystrophic calcification or ossification of tendon insertion. In the study of the initial stages of arthrosis on necroptic material roentgenologically 158 and of these histologically 62 hip joints were investigated. A typical picture of so-called non-inflammatory enthesopathy was present in thirteen cases on the major and in three cases on the minor trochanter. Histologically, we observed enthesopathy-like changes, but to a much lesser extent in the insertions of the articular capsule. These pictures which on the X-ray resembled initial osteophytes were found seven times on the head of the femur and fourteen times on the edge of the joint acetabulum. There was no correlation to osteoarthrosis.

Female↗
PubMed1979

Donor specific suppressor cells in association with rejection of a renal allograft.

Details are presented of three aspects of immunological monitoring in a single instance of severe irreversible rejection of a renal allograft. Rejection is associated with strong evidence of lymphocyte mediated cytotoxicity (LMC). During this period reduced responsiveness of recipient cells to stimulation in vitro by donor cells is observed; this is more reduced than is responsiveness to random cells. Donor-specific suppressor cells also develop, as detected in two systems. It is postulated that the data are evidence that competition exists between different agressive and suppressive subpopulation of recipient lymphocytes.

Analgesics↗
PubMed1978

[Arthrotic manifestations on the patella in the x-ray and microscopy pictures].

40 patellae of different age groups were examined by X-ray and histology. X-ray changes found in the cartilage, corticalis and cancellous bone were in full agreement with histological findings. However, more than a quarter of the patellae were found to be affected by microscopic fibrillation of the surface of the cartilage without any demonstrable changes in the cartilage proper. In all those cases except one, however, roentgenograms helped to detect changes in the corticalis or also cancellous boneof the lamellae such as are associated with bone reconstruction, mostly in the form of subchondral bone lamella dilatation and of the thickening of adjacent cancellous bone trabeculae.

Adult↗
PubMed1976

[Changes of articular cartilage in coxarthrosis].

In cases of advanced coxarthrosis indicated for total endoprosthesis [a total of 216 observations made] the most frequent changes included cases of lowering, defibration or even complete abrasion of cartilage in the most exposed segment of the articular head [196x]. Small patches of connective cartilage [133x] were found in the areas of abrasion. There were rare cases of chondrocyte nests as a manifestation of proliferation [25x]. The usual picture of coxarthrosis had exceptions in the form of flatly worn-out surface areas (34X) and pannus (7X). These may have been cases of secondary coxarthrosis accompanying some other, clinically overlooked, underlying process.

Biopsy↗
PubMed1976

Fibroblast lysis by lymphocytes from normal persons and SLE patients on short-term cultures.

Lymphocytes from thirty-six normal individuals of both sexes with ages ranging from 4-89 years were tested for their cytotoxic activity against short term cluters of fibroblasts from nine foetal umbilical cords and nine adult skin samples. Wide variability in the amount of fibroblast lysis was observed. Adult male lymphocytes caused significantly higher lytic activity than lymphocytes of adult females against both types of targets. Cell-mediated target cell reduction was not confined to allogeneic target cells. There was also killing of autochthonous cultured fibroblasts. Some individuals' sera inhibited the fibroblast lytic activity of their own lymphocytes. These cell-mediated reactions are directed against unknown antigenic specifications, probably not histocompatibility antigens, and give evidence of the problem of how to measure normal controls in the microcytotoxicity test in allogeneic human testing. Both autochthonous and allogeneic target cell lysis were also observed in SLE patients.

Adolescent↗