Biomedical subjects

V Peña

Publications and source records attributed to V Peña.

6 recordsLinked to original sources

PubMed2006

Interfacially controlled transient photoinduced superconductivity.

We report on a large transient photoinduced enhancement of the superconducting critical temperature (DeltaTc = 23 K) in epitaxial YBa2Cu3O(6.7)/La(0.7)Ca(0.3)MnO3 bilayers upon visible light illumination. The effect relaxes with a characteristic time of 100 s at low temperatures, which is 4 orders of magnitude faster than the persistent photoconductivity or persistent photoinduced superconductivity previously found in single high-Tc superconducting films. This result is discussed in terms of light induced charge transfer through the interface similar to what happens in semiconductor junctions.

Journal Article↗

PubMed2006

Comparison of clinical, ultrasonographic, and biochemical differences at the beginning of puberty in healthy girls born either small for gestational age or appropriate for gestational age: preliminary results.

CONTEXT: There are limited and controversial data concerning puberty characteristics in girls born small for gestational age (SGA). OBJECTIVE: The objective of the study was to document clinical, ultrasonographic, and biochemical characteristics at the beginning of puberty in matched healthy girls born either SGA or appropriate for gestational age (AGA) recruited from the community. PATIENTS: Inclusion criteria were breast Tanner stage II and a body mass index between the 10th and 95th percentiles. INTERVENTIONS: Recruited subjects underwent a complete physical exam, bone age, and ultrasound measurements of the internal genitalia. Hormonal assessment included fasting early morning dehydroepiandrosterone sulfate, androstenedione, SHBG, inhibin-B, FSH, LH, estradiol (E2), 17-hydroxyprogesterone (17OH Prog), and testosterone. Thereafter, a GnRH agonist test (leuprolide 500 microg, sc) was performed with FSH and LH at time 3 and 24 h for E2, 17OH Prog, and testosterone. RESULTS: Sixty-five girls (35 AGA, 30 SGA) with a mean age of 9.9 +/- 1.03 (7.8-12.5) yr, similar bone age/chronological age (1.02 +/- 0.8 in AGA and 1 +/- 0.76 in SGA), median height of 1.35 +/- 0.06 cm, and similar waist to hip ratio were included. No differences in the presence of pubic hair, axillary hair, apocrine odor, or ultrasound measurements were found. SGA girls had increased baseline E2 as well as stimulated E2 and 17OH Prog. CONCLUSIONS: In a preliminary sample of lean, healthy girls recruited from the community born either SGA or AGA, we observed slight hormonal differences at the beginning of puberty. Longitudinal follow-up of this cohort will allow us to understand whether these differences are maintained and have a clinical impact in their pubertal development.

17-alpha-Hydroxyprogesterone↗

PubMed2005

Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children.

AIMS/HYPOTHESIS: Insulin resistance and type 2 diabetes risk in human subjects who were small-for-gestational-age (SGA) at birth may be a consequence of rapid early postnatal weight gain. MATERIALS AND METHODS: We prospectively studied early changes in fasting insulin sensitivity and insulin secretion, assessed by a short intravenous glucose tolerance test that was conducted several times from birth to 3 years of age in 55 SGA (birthweight below fifth percentile) newborns and in 13 newborns with a birthweight appropriate for gestational age (AGA). RESULTS: Most SGA infants showed postnatal upward weight centile crossing and by 3 years were similar in size to AGA infants. SGA infants had lower pre-feed insulin levels at postnatal age 48 h than AGA infants (median 34.4 vs 59.7 pmol/l, p<0.05), but by the age of 3 years they had higher fasting insulin levels (median 38.9 vs 23.8 pmol/l, p<0.005), which were related to rate of weight gain between 0 and 3 years (r=0.47, p=0.0003). First-phase insulin secretion did not differ between SGA and AGA infants, but SGA infants had a lower glucose disposition index (beta cell compensation) (median 235 vs 501 min mmol(-1) l(-1), p=0.02), which persisted after allowing for postnatal weight gain (p=0.009). CONCLUSIONS/INTERPRETATION: SGA infants showed a marked transition from lower pre-feed insulin and increased insulin sensitivity at birth to insulin resistance over the first 3 years of life. This transition was related to rapid postnatal weight gain, which could indicate a propensity to central fat deposition. The additional observation of reduced compensatory beta cell secretion underlines the need for long-term surveillance of glucose homeostasis in all SGA subjects, whether or not they show postnatal catch-up growth.

Birth Weight↗

PubMed2005

Giant magnetoresistance in ferromagnet/superconductor superlattices.

We show magnetoresistance in excess of 1000% in trilayers containing highly spin-polarized La0.7Ca0.3MnO3 and high-Tc superconducting YBa2Cu3O7. This large magnetoresistance is reminiscent of the giant magnetoresistance (GMR) in metallic superlattices but with much larger values, and originates at spin imbalance due to the injection of spin-polarized carriers. Furthermore, in contrast to ordinary GMR, the magnetoresistance is intimately related to the superconductivity in the YBa2Cu3O7 layer and vanishes in the normal state. This result, aside from its fundamental importance, may be of interest for the design of novel spintronic devices based on ferromagnet/superconductor structures.

Journal Article↗

PubMedDate not supplied

A hybrid method to compute accurate efficiencies for volume samples in gamma-ray spectrometry.

In recent years, Monte Carlo (MC) methods have been increasingly applied to cope with variability in photopeak efficiencies due to matrix effects. But to obtain proper results only by numerical simulation, especially at low energies, sample bulk density and chemical composition must be well characterized. In this paper, we propose a method that combines both experimental measurements and MC simulations, being applicable to matrices of unknown composition. A transmission measurement of a 210Pb point source through the sample allows one to compute accurately its photopeak efficiencies at energies above 46.5 keV. The method is validated for several inorganic and organic matrices measured in Petri dishes geometry.

Algorithms↗

PubMedDate not supplied

Radon emanation measurements using silicon photodiode detectors.

Driven by the global concern about radon hazards, a wide variety of methods to measure radon and its decay products have been developed. Pin silicon photodiodes are increasingly applied in this field, their main advantages being high detection efficiency for alpha particles and low cost. In this paper, we present a system to determine the emanation factor for 222Rn from porous material based on a pin photodiode. This equipment is valid both for field and laboratory measurements, allowing to monitor the external emanation conditions by means of temperature, humidity and pressure sensors. To illustrate the capabilities of the system, we present two case studies of samples with high and low 226Ra content. The activity of this radionuclide in the samples had been previously determined by gamma-ray spectrometry.

Electrochemistry↗