[Spreading infectious endocarditis: an example of vascularitis].
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Biomedical subjects
Publications and source records attributed to V Pegoraro.
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The authors review critically such parameters as symptomatology, post-micturition residual urine, bladder trabeculation and uroflowmetry that in the actual state of the art appear more accredited in the evaluation of lower urinary tract obstruction. All have some interpretative limits. However, uroflowmetry appears to be the most reliable and for this reason it is the first step in the study of suspected infravesical obstruction. It can discover equivocal situations in which pressure-flow studies only supply diagnostic help in order to avoid false diagnosis of infravesical obstruction and useless therapeutic approaches.
A case of spontaneous perinephric hematoma due to a renal cell sarcomatous carcinoma in a 46-year-old woman is reported. Immunocytochemical analysis for the intermediate-sized filament proteins allowed a specific diagnosis of pseudosarcomatous renal carcinoma. Clinical, radiographic, sonographic and CT findings of spontaneous perinephric hematoma are discussed and the therapeutical modalities are briefly outlined.
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A retrospective study was carried out on 200 consecutive superficial transitional cell carcinomas of the bladder in order to identify which factors could influence the recurrence and/or progression of the tumor. Many parameters were considered, such as stage, grade, number, size, site, tumor-free interval and bladder mucosa mapping. A careful histological study of the initial tumor was employed and the tumors confined to the stromal core of the papillary tumor (T1a) were separated from those with invasion of the lamina propria of the bladder wall (T1b). The behavior of the T1b lesions observed in our study will be discussed in a forthcoming article. Recurrence occurred in 83% of our patients, and it was influenced by number and grade of the tumor and by the presence of dysplasia in normal-appearing mucosa. In 20% of our patients tumor progression occurred. Tumor progression was correlated with invasion of the lamina propria of the bladder wall, high-grade neoplasias, tumor-free interval, dysplasia or carcinoma in situ in normal-appearing mucosa. The results of our study suggest that, by these risk factors, a better prediction of the behavior of superficial transitional cell carcinoma and, as a consequence, more appropriate treatment can be provided.
We have reviewed the tumor progress in 46 patients who presented T1b lesions in a previous study on the prognosis of superficial bladder cancer. A group of 12 patients with single or very few localizations was treated by transurethral resection. Five patients progressed and were submitted to cystectomy. Two of these 5 patients died within 3 years of the surgical treatment. Twenty-seven patients with multiple lesions underwent cystectomy soon after the initial diagnosis. Nearly 30% experienced progression; 4 patients died within 4 years after cystectomy. A delayed cystectomy was performed in 7 patients with multifocal disease; in all but one the tumor progressed; 5 patients died between 7 and 28 months after the surgery.
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The authors report their experience in the diagnosis of the hidden neoplasia based on the follow-up of 27 patients with carcinoma in situ of the bladder. Urine cytology and mapping histology are the most effective examinations for the detection and follow up of an occult urothelial neoplasm.
The authors report their experience in the treatment of 21 patients with carcinoma situ of the bladder. Although the safest therapy is radical cystectomy this operation nevertheless is extremely mutilating. For these reason initially we prefer local chemotherapy with ADM continued with careful follow-up of the patient.
Pelvic lymphadenectomy prior to radical prostatectomy is essential to detect lymph nodal extension of prostatic cancer. Accuracy obtained by means of frozen section examination of the nodes is particularly favourable. Frozen sections correspond to paraffin sections in 100% of the cases. Authors' experience in 42 consecutive patients candidates to radical prostatic procedure is herein presented.
The authors present the personal experience concerning with the use of the rigid ureteropyeloscopes. Two groups of patients have been studied. In the first one (14 subjects) the ureteropyeloscopy was performed either with diagnostic or therapeutic purposes, in the second one, just as upper urinary tract endoscopic control in patients previously submitted to distal ureteral resection and ureteroneocystostomy for urothelial neoplasia of the distal ureter. The authors presenting the personal results and complications, discuss the indications for the upper urinary tract endoscopy with rigid instruments.
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24 cases of penile carcinoma, occurred from 1970 to 1979, have been examinated. The role of limphoadenectomy, the treatment of the primitive lesions and their consequences are discussed. It is opinion of the authors that the risks and the benefits of the treatment must be carefully evalued.
The authors report on the third case in the world of mesonephric adenocarcinoma of the bladder. The tumour which may well derive from embryonic rests of mesonephric origin, developed in the region of the bladder neck and proximal urethra. The symptoms that led to the consultation consisted of dysuria with episodes of complete urinary retention. Clinical examination and IVU confirmed the presence of a tumour which could be seen on endoscopy, thus enabling biopsy. As there were no metastases, irradiation with telecobalt cured this patient. The undesired side-effect was the development of bladder retraction. This necessitated a cutaneous transcolic ureterostomy. The histological structure of these tumours is distinctive and easily recognizable and should not be missed by the pathologist. In regard to this rare tumour, it is interesting to note its radiosensitivity, and hence the potential of radiotherapy to effect a cure in patients so afflicted.
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