Biomedical subjects
Publications and source records attributed to V Peters.
Foreign-body granulomas in the hand can appear secondary to an unrecognized foreign material. In a six-year-old boy, an extensive sterile osteitis of the second metacarpal bone appeared adjacent to a wood splinter.
Although no frequently described in the podiatric literature, nuclear medicine imaging may be of great assistance to the clinical podiatrist. This report reviews in detail the use of modern nuclear medicine approaches to the diagnosis and management of the diabetic foot. Nuclear medicine techniques are helpful in evaluating possible osteomyelitis, in determining appropriate amputation levels, and in predicting response to conservative ulcer management. Specific indications for bone, gallium, and perfusion imaging are described.
Thallium 201 (Tl-201) as a marker of regional tissue perfusion is described as a diagnostic aid in a case of exercise-induced vasospastic disease affecting the lower leg of a physically active young adult male who had no evidence of atherosclerotic disease. The success and failure of various therapeutic attempts made in behalf of this patient have been monitored by repeated Tl-201 administrations. Exercise-associated ischemia in tissues other than the myocardium can be investigated with Tl-201.
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Twenty-seven children with previously untreated Hodgkin's disease (CS I-2, II-13, III-3, IV-9) were given three cycles of MOPP to induce a remission which was consolidated with extended field radiation (2000--3500 rad) and three cycles of MOPP. Surgical staging was discontinued. Twenty-five of 27 children have not relapsed (range 15+--64+ months; median 39+ months); two children have died, one of uncontrolled Hodgkin's disease and one of acute infection while in complete remission. Actuarial 3 and 5 year survival rates and relapse-free rates are 91%. The merits of this treatment approach are discussed.
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Bubbles rising through suspensions of the bacteriophages T2 and T4 and of Escherichia coli adsorb and eject these particles in droplets that are formed when the bubbles burst. The concentration of the viruses in ejected droplets, determined from electron microscopy, exceeded the suspension concentration by 50 times. Similar results were obtained for Escherichia coli. The viability of some of the adsorbed particles was established by biological counts.
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Clearly defined indications for major extirpation procedures in metastatic mammary carcinoma are lacking. A reassessment of experience with 222 patients (133 after adrenalectomies and 89 after hypophysectomies) was therefore undertaken. This experience has changed our previous opinions that such procedures should be used only at the end of a sequential program of treatment.It is now felt that extirpation is only contraindicated in menopausal women with a duration of disease less than two years or when there is symptomatic disease of vital organs. Otherwise, early extirpation is recommended. When vital organ involvement is recognized in the asymptomatic stage or when screening of premenopausal women by castration indicates continuing hormonal dependency, then early extirpation is indicated.Both the qualitative and the quantitative responses achieved exceed those obtained by other measures when widely disseminated disease is present. The objective remission rate (34% after adrenalectomy and 19% after hypophysectomy) for longer than six months is worth while.
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