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Biomedical subjects

V Petrů

Publications and source records attributed to V Petrů.

At least 19 recordsLinked to original sources
PubMed1992

[Manifestations of ocular allergy (atopy) in childhood. Present possibilities of therapy].

Vernal catharr of the conjunctivae is frequently the initial symptom of dermorespiratory syndrome. In all nine children where ophthalmological and other manifestations of varying extent of general atopy were combined, the authors revealed a marked increase of immunoglobulin IgE 220-2230 I.U./ml (normal values up to 150 I.U./ml) and polyvalent allergy. In the treatment of vernal catharr the authors used a combination of antihistaminics and preventive immunopharmaceutical preparations administered locally (Spersallerg and Opticrom) or as general medication (Hismanal and Zaditen), supplemented by aimed hyposensitization. In acute stages of the inflammation of the eye the authors administered Triamcinolon into the upper transient conjunctival fold. In the treatment of secondary infection Garasone was most effective. A finding interesting from the immunological aspect was vernal catharr without general symptoms of atopy in a patient with hypogammaglobulinaemia IgA.

Child↗
PubMed1991

[Sodium nedocromil (Tilade) in the treatment of severe forms of asthma in children].

Twenty-four children with medium severe and severe asthma were treated for a period of three months with sodium nedocromil (Tilade), twice a day 4 mg in a dispensed aerosol. All patients took concurrently on a long-term basis various antiasthmatic drugs and half the children also corticosteroids. Evaluation of the effect was based on changes of the clinical picture, drug consumption and some other examinations. The authors compared the state one month before onset of treatment with the last month during the three-month therapy and one month after termination of therapy. In the entire group of patients gradually the number of asthmatic attacks declined, the greatest decline was observed during the third month of treatment. At the same time a statistically significant improvement of symptoms was recorded characterizing the clinical condition of the patients during day and night. Both these parameters deteriorated again one month after termination of treatment. The consumption of aerosol sympathomimetics and partly also of theophylline declined. Corticotherapy was not affected and pulmonary functions did not improve. The investigated immunological parameters did not change. With the exception of two patients where inhalation had an irritating effect, treatment was tolerated well and produced no side-effects. Sodium nedocromil is a drug which extends the spectrum of preventive antiasthmatics, but has no major effect on children with the most severe forms of asthma.

Adolescent↗
PubMed1989

[Gastroesophageal reflux in childhood asthma].

Gastrooesophageal reflux (GER) may participate in the development and persistence of asthmatic complaints. For its detection various examination methods may be used such as oesophagography, oesophageal manometry and pH-metry, ultrasonography, isotope scintigraphy, oesophagoscopy. By means of these methods we detected GER in 27 children, i. e. 41% of a total number of 65 asthmatic children with a medium severe and severe form of the disease. Because of failure of conservative treatment of reflux and hitherto used anti-asthmatic therapy, in 1984 to 1986 in 11 children surgical treatment of reflux by Nissen's fundoplication was indicated. The group comprised 9 boys and 2 girls aged 2 to 14 years. The effect of the operation was evaluated after an interval of 1.5 to 3.5 years following operation. Surgical treatment was successful in four patients (36%) and partly successful in 5 patients (45%). Despite these encouraging results the indication surgery in GER in asthmatic patients still is strictly individual.

Adolescent↗
PubMed1989

[The further development of bronchial asthma which began in childhood].

The paper evaluates the contemporary health status in 115 former child asthmatics, investigated in the past at the allergological department of the First Paediatric Clinic and Faculty Policlinic in Prague-Motol. The data were obtained by processing of a questionnaire and retrospective analysis of the patients' health records. The mean age of the investigated group is 26 years (21-37) incl. 77 men and 38 women. Of these 85, i.e. 74%, still suffer from asthma in adult age, incl. almost half (55 patients) who suffer from the milder form, only one quarter suffers from the more severe form (30 patients) and in one quarter the quiescent stage has been reached. In those where asthma persists there is concurrent eczema (26%), pollinosis (44%), other forms of allergy (43%). Where asthma is in the quiescent stage, eczema is present in 10%, pollinosis in 33% and other allergies in 27% of the investigated subjects. A greater probability of favourable development is in boys as compared with girls and in those without a family-history of allergy and where the disease developed only during late childhood and the patients themselves do not suffer from any other allergosis. A positive family-history of allergy, early onset of the disease and concurrent eczema signalize a poorer prognosis.

Adult↗
PubMed1988

[Pollinosis. 1].

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Humans↗
PubMed1988

[Pollinosis. 2].

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Child↗