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Biomedical subjects

V Petronic

Publications and source records attributed to V Petronic.

7 recordsLinked to original sources
PubMed1999

Concomitant radiotherapy and carboplatin in locally advanced bladder cancer.

OBJECTIVE: The aim of the study was to assess the efficacy and safety of concomitant radiotherapy (CRT) and carboplatin. PATIENTS AND METHODS: From 1992 until 1997, 67 patients with T3 invasive bladder cancer (IBC) were treated using CRT and carboplatin. X-Ray radiotherapy (10 MeV) was applied using LINAC in a locoregional technique, with a total tumor dose of 65 Gy in 32 fractions. Carboplatin was administered as a bolus infusion once a week, on day 5, up to a total dose of 900 mg. RESULTS: The most frequent toxicity was hematological. Of the 67 treated patients, 92.5% achieved a clinically complete response, and 7.5% developed progressive disease during therapy. The 5-year overall survival was 55% and disease-free survival was 35%. CONCLUSION: CRT and carboplatin appear to be safe and extremely active in the treatment of T3 IBC, but the results should be confirmed in a randomized study.

Adult↗
PubMed1997

Solitary kidney stone treatment by extracorporeal shock wave lithotripsy.

OBJECTIVES: To determine if solitary kidney stones can be successfully treated with ESWL. METHODS: 38 patients were examined, 34 stones were treated on a Dornier lithotripter HM-3, and 4 on a Siemens Lithostar. 17 stones were larger than 400 mm2, 11 were incomplete and 6 complete staghorn calculi. In 26 patients a catheter was placed before lithotripsy, double-J and ureteral stents in 14 and 12, respectively. RESULTS: Successful outcome of lithotripsy was achieved in 34 patients (89%). Complete fragment elimination was recorded in 23 patients (60%), and in 11 (29%) a negligible residuum was noticed. Treatment failure was recorded in 4 patients. In 3 patients fragment elimination was poor, and in 1 patient 3 ESWL sessions were not sufficient to commence stone destruction and we decided to operate on this patient. Anuria occurred in 4 patients (10%). CONCLUSIONS: Our results suggest that ESWL can be successfully used in the treatment of urolithiasis in a solitary kidney. Even in cases of staghorn stones, the obligatory placement of a double-J catheter, and strategic lithotripsy in several sessions result in a high success rate with a tolerable risk of complications.

Anuria↗
PubMed1989

Xanthogranulomatous pyelonephritis.

Xanthogranulomatous pyelonephritis is a rare chronic form of pyelonephritis with a clinical presentation often suggestive of a renal mass. We present 51 patients with histologically proven xanthogranulomatous pyelonephritis who were treated by nephrectomy. The results are discussed and compared with those from the literature.

Adolescent↗