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Biomedical subjects

V Petruzzellis

Publications and source records attributed to V Petruzzellis.

At least 19 recordsLinked to original sources
PubMed1994

Idiopathic chronic pigmentary purpura. Findings in 22 cases and proposal of a new classification.

22 cases of Idiopathic Chronic Pigmentary Purpura are described in 9 males and 13 females with an age range from 14 to 66. Clinical picture, morphology and distribution of the lesions varied. Laboratory and instrumental investigations excluded the presence of systemic diseases or toxic/pharmacological factors responsible for the purpuric eruption. On the basis of the clinical aspects and the histopathological results, an exclusively morphological classification of idiopathic purpuras in macular, papular and eczematic forms is proposed, maintaining that the old nosography is not justified and also taking into account the pathogenetic overlapping confirmed by recent immuno-histochemical and ultramicroscopical studies.

Adolescent↗
PubMed1991

[Evaluation of D-dimer levels in obliterating arteriopathies].

A research has been carried out for the evaluation of D-dimer serum levels by the ELISA technique at 1:200 and 1:500 dilution in 30 male patients suffering from chronic obliterating arteriopathy of the lower limbs at second and third stage of the disease and in a homogeneous control group for number, sex and age. The value difference between the two groups, for both dilutions, seems to be highly significant with higher levels in the arteriopathic patients. The extent of D-dimer levels has shown an obvious correlation in respect to the entity of the arteriopathy. It has been also observed a significant correlation between the D-dimer and LDL levels in the arteriopathic patients. The usefulness of such a parameter in order to prevent trophic lesions in the obliterating arteriopathy is emphasized for the possibility of establishing an early and prolonged thrombolytic therapy.

Aged↗
PubMed1990

[Epidemiologic observations on the subject of phlebopathy of the legs and its dermatologic complications].

The authors carried out an epidemiological study on a group of 10032 patients with chronic venous insufficiency, composed of 2686 males (26.77%) and 7346 females (73.23%). The case report is divided into varicose diseases (83.30%) and sequelae of deep vein thrombosis (16.70%). As well as the relationship between sex and age is considered rate of dermatological complications, with regard both to the type of venous diseases (65.54% varicose and 34.46% post-thrombotic) and to their clinical manifestations. As well as any family connection, various environmental factors are taken into account such as the patient's work, noxae iatrogenic, pregnancy and obesity.

Adolescent↗
PubMed1990

[Clinico-pathogenetic observations on the subject of "superficial vasculitis"].

A clinical, histopathologic, laboratory and therapeutic study in 44 subjects with "superficial vasculitis", consecutively observed during the last two years, has been carried out. The findings showed that 1. the anamnesis was sometimes not relevant; 2. the clinical pictures were not in a regular manner correlated with histologic reports (a polymorphonuclear infiltrate with leukocytoclasis or a lymphomononuclear + one); and 3. a non-correlation between clinical, histologic and etiologic data. Infectious agents were responsible, mostly pyogenic bacteria, Mycobacterium tuberculosis, and hepatitis B virus; Chlamydiae were rarely responsible, whereas the etiologic role of Toxoplasma was uncertain. In this respect, drugs were not relevant. All these agents seem to act on the immunological response of the patient with previous microvascular changes (diabetes, chronic venous insufficiency). The latter condition seems to play a predominant role: the recovery of the lesions and/or their relapse shows the same behaviour both in case of etiological and symptomatic therapy.

Adolescent↗
PubMed1990

[A retrospective study of 200 cases of lichen].

In this study the data on 200 patients affected by various features of lichen planus (LP) are reported. All subjects were in-patients of the Department of Dermatology, Bari, from 1973 to 1988. In 87% of cases the disease appeared as lichen tuber planus, and in 9% there was involvement of mucous membranes. Equal involvement of sex incidence has been found, and the patients were middle-aged (mean, 47 years). The lesion were not subsided in about 10% of cases. Associated fortuitous skin conditions were mainly alopecia areata and vitiligo. In addition, LP has been observed in association with diabetes (8%) and hepatic diseases (10%). These last values could appear relevant, but in our region, Apulia, both diabetes and hepatitis, and especially B-hepatitis, are very frequent diseases. Our clinical follow-up did not allow to consider LP as a symptom of other subsequent organic diseases.

Diabetes Complications↗
PubMed1989

[Topical therapeutic action of azelaic acid in polymorphous acne].

Thirty patients of either sex (23 M, 7 F) ranging in age between 16 and 36 years, affected of acne vulgaris, were given 20% azelaic acid cream over a period of 6 months. The product, very well tolerated, was significantly and substantially effective for all types of acne, especially for the deep lesions, i.e. nodules and cysts. The rates of improvement obtained indicate that azelaic acid can interfere with various aetiopathogenetic process of acne.

Acne Vulgaris↗
PubMed1985

[Therapeutic action of oral mesoglycan in the pharmacologic treatment of the varicose syndrome and its complications].

The comparative therapeutic efficacy of mesoglycan and a capillary protective drug derived from rutin was evaluated in a clinical study conducted on a group of patients with varicose syndrome and/or its complications. The clinical assessment of the results obtained was followed by a series of investigations aimed at identifying the action mechanism of the drugs under study. In the experimental model adopted, mesoglycan was found to be well tolerated and effective both in absolute terms and in comparison with the drug used for comparison. Apart from the clinical efficacy of mesoglycan, it was also shown to increase transcutaneous O2 perfusion and blood flow as evidenced by filtrability. On the basis of these results it is suggested that the clinical action and tolerability of mesoglycan make it a valuable aid in the arduous task of treating varicose syndrome and its complications.

Administration, Oral↗
PubMed1984

[Capillaroscopic studies in connective tissue inflammations].

Capillarioscopy has been unjustifiably neglected in the study of connective tissue diseases, where examination of the microcirculation is clearly important. A study of 80 cases is reported. 12 systemic lupus, 11 progressive systemic sclerosis (PSS), 20 rheumatoid arthritis (including 3 juvenile and 2 Still's disease); 9 Raynaud's disease (of which 3 idiopathic, 4 with rheumatoid arthritis and 2 with UCTD); 1 dermatomyositis; 11 other CTD (2 overlap syndrome--1 lupus + dermatomyositis; 1 lupus + PSS--3 Sjögren syndromes with rheumatoid arthritis, 1 MCTD, 2 primary mixed cryoglobulinaemia, 1 systemic vasculitis, 1 Behçet syndrome, and 1 UCTD); 9 miscellaneous forms (3 psoriatic arthropathy, 1 rheumatic pelvispondylitis, 1 allergic dermatitis, 1 pulmonary TB, 1 ulcerative colitis; 1 scapulohumeral periarthritis, 1 unclassifiable rheumatism; 7 healthy subjects). During capillarioscopy, from one to nine slides were prepared for each subject. These were interpreted separately by three persons who were unaware of the respective diagnosis. Calibre, tortuosity, length and number of capillaries were recorded, plus the visibility of the subpapillar plexus, height and number of the termal, subungual and/or ungual vallum haemorrhage, plugging. It was found that PSS, dermatomyositis, MCTD, and overlap-PSS revealed a very typical common pattern, possibly pathognomonic, namely marked reduction in the number of capillaries + megacapillaries. The other forms presented less evocative diagnostic patterns, though they were fairly indicative in some instances. Clinical correlations of particular significance with respect to prognosis, however, were not observed.

Arthritis, Rheumatoid↗
PubMed1982

[Therapeutic effect of a combination of bufenine and beta-escine as an oral delayed-action drug in obliterating arterial diseases of the lower limbs].

Reference is made to the clinical and instrumental results observed in 40 subjects with chronic obliterating arteriopathy of the lower limbs treated for 90 days with a projective protocol based on a per os retard combination of bufenine and beta-escine. Attention is drawn to the vasoactive and antioedemigenic activity of the combination, its good tolerance, and easy administration.

Administration, Oral↗