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Biomedical subjects

V Pointillart

Publications and source records attributed to V Pointillart.

At least 19 recordsLinked to original sources
PubMed2004

Radiolucent cage for cervical vertebral reconstruction: a prospective study of 17 cases with 2-year minimum follow-up.

In cervical spondylotic myelopathy, extended anterior spinal cord decompression necessitates subsequent stable vertebral reconstruction. Reconstruction with an iliac crest graft and screw-plate fixation gives satisfactory clinical and radiological results, but they are often compromised by morbidity involving the bone harvest. The purpose of this study was to evaluate the contribution to cervical reconstruction of a biocompatible, radiolucent cage combined with screw-plate fixation, making use of bone harvested in situ. This prospective study was performed between July 2000 and March 2001 in eight women and nine men (mean age, 55 years) operated for cervical spondylotic myelopathy. Situated between levels C3 and C6, the cage was inserted after one corporectomy in ten patients, two corporectomies in five patients, and three corporectomies in two patients. The cage consisted of a polyester mesh impregnated with poly-L-lactic acid (PLLA) conferring temporary rigidity to the cage during bony fusion. Clinical and radiological follow-up (plain films, computed tomographic reconstruction in three cases) was performed at 2 months, 6 months, 12 months, 24 months and 36 months, postoperatively, with a mean follow-up of 30 months. Functional results were evaluated according to the Japanese Orthopaedic Association's scoring system. An independent surgeon assessed the radiological evidence of anterior cervical fusion using the grades proposed by Bridwell [6]. Every patient experienced neurological recovery. At last follow-up, radiological findings were consistent with grade I (complete fusion) in five cases, grade II (probable fusion) in ten cases, grade III (radiolucent halo in favor of non fusion) in one case, and grade IV (graft lysis) in one case with persistent neck pain. In three cases there was screw breakage (two grade II, one grade IV). None of these cases required surgical revision at latest follow-up. In extensive spinal cord decompression through an anterior approach, cervical reconstruction using the present type of cage can achieve clinical results comparable to conventional techniques. The rigidity of the cage meets biomechanical imperatives. Its radiolucency permits one to monitor the course of consolidation, contrary to metal cages. The cases of probable non-fusion and screw breakage were not accompanied by signs of instability on the flexion extension films. This cage meets the biologic and biomechanical imperatives of cervical reconstruction. It obviates complications involving bone harvest.

Adult↗
PubMed2003

Course of Modic 1 six months after lumbar posterior osteosynthesis.

STUDY DESIGN: A prospective study was conducted to investigate the outcome of the Modic Type 1 inflammatory signal in magnetic resonance imaging (MRI) in 17 patients with chronic low back pain 6 months after instrumented posterior lumbar arthrodesis. OBJECTIVE: To assess the course of the inflammatory signal after stabilization of a painful intervertebral segment by posterior instrumentation alone visualized on MRI systematically performed 6 months after the operation. SUMMARY OF BACKGROUND DATA: In 1988, Modic and colleagues described three degenerative stages of vertebral endplates and subchondral bone. The inflammatory stage, or Stage 1, is correlated with substantial functional disability. According to these authors, Stage 1 lesions naturally transform into Stage 2, the fatty stage. In the literature, patients with Modic 1 signal tend to have good results after arthrodesis, better than those with Modic 2 lesions. METHODS: This study included 17 patients (average age, 46 years) who had experienced chronic low back pain more than 1 year and showed Modic 1 changes in MRI and disc narrowing on plain radiographs. Every patient underwent posterior screw-rod osteosynthesis and posterolateral arthrodesis. Disc disease had occurred subsequently to discectomy (n = 7), rapidly destructive disc disease (n = 5), or spondylolisthesis resulting from spondylolysis (n = 5). Clinical results were assessed according to a visual analog scale for pain, a functional disability score for the evaluation of patients with low back pain (Eiffel), and the validated French version of the self-administered Dallas quality-of-life test (DRAD). RESULTS: Systematic MRI at 6 months showed transformation from Modic 1 to Modic 0 (normal endplate signal) in 4 patients and transformation from Modic 1 to Modic 2 in the remaining 13 patients. Clinical evaluation was performed at 6 months (at the same time as the MRI) and at 1 year. In every patient, there was improvement in the visual analog score and the functional score, which remained stable at 1 year. CONCLUSIONS: According to the literature, most Modic 1 lesions change to become Stage 2 lesions in 18 to 24 months. In this study, 17 patients with Modic Type 1 signal had changes after 6 months. It appears that posterior osteosynthesis combined with posterolateral arthrodesis accelerates the course of Modic 1 lesions, probably by correcting mechanical instability.

Adult↗
PubMed2001

Cervical disc prosthesis in humans: first failure.

STUDY DESIGN: Prospective preliminary trial of a cervical disc prosthesis. OBJECTIVE: To study the feasibility, efficacy in maintaining intervertebral mobility, and complications of a low-profile disc prosthesis implanted after single-level cervical discectomy. SUMMARY OF BACKGROUND DATA: Since studies reported by Baba et al, there is fear that degeneration of the intervertebral disc levels adjacent to cervical arthrodesis may be exacerbated by this arthrodesis. For this reason, several cervical prostheses have been designed as an alternative to arthrodesis. None of these prostheses, some of which are bulky, has been shown to be efficacious. METHODS: Five women and five men (average age, 36 years) underwent implantation of the present disc prosthesis after single-level discectomy. The discectomy was performed for cervical disc herniation that resulted in cervicobrachial pain for more than 3 months. None of the patients exhibited intervertebral instability on bending films. Preoperative magnetic resonance studies showed a noncontained disc herniation in all 10 patients and osteophytes in 2 of the patients. RESULTS: The cervicobrachial pain resolved in all 10 patients. Intense neck pain developed in 1 patient who underwent revision surgery to remove the prosthesis and perform an arthrodesis. Another patient developed neck pain but refused the proposed revision operation. Bending films showed mobility of the intervertebral space containing the prosthesis in both of these patients. In the 8 patients who remained pain free after the operation, lateral bending films at follow-up found no mobility of the implanted disc level. Five of these eight patients had circumferential fusion, 2 had posterior fusion, and 1 had anterior fusion. CONCLUSION: This prosthesis failed to achieve the desired effect because the intended mobility failed to persist in 8 of the 10 patients and pain developed in the other 2 patients, in whom the mobility persisted.

Adult↗
PubMed2000

Pharmacological therapy of spinal cord injury during the acute phase.

STUDY DESIGN: Prospective, randomized clinical trial. SETTING: France. OBJECTIVES: To evaluate the safety and effect on neurological outcome of nimodipine, methylprednisolone, or both versus no medical treatment in spinal-cord injury during the acute phase. METHOD: One hundred and six patients who had spinal trauma (including 48 with paraplegia and 58 with tetraplegia) were randomly separated into four groups: M=methylprednisolone (30 mg x kg(-1) over 1 h, followed by 5.4 mg x kg(-1) x h(-1) for 23 h), N=nimodipine (0.015 mg x kg(-1) x h(-1) for 2 h followed by 0.03 mg x kg(-1)h(-1) for 7 days), MN (both agents) or P (neither medication). Neurological assessment (ASIA score) was performed by a blinded senior neurologist before treatment and at 1-year follow-up. Early spinal decompression and stabilization was performed as soon as possible after injury. RESULTS: One hundred patients were reassessed at 1 year. Neurological improvement was seen in each group (P<0.0001), however no additional neurological benefit from treatment was observed. Infectious complications occurred more often in patients treated with M. Early surgery (49 patients underwent surgery within 8 h of their accident) did not influence the neurological outcome. The only predictor of the latter was the extent of the spinal injury (complete or incomplete lesion). CONCLUSION: The present study confirms the absence of benefit of pharmacological therapy in this indication. Because of the paucity of clinical studies that demonstrate the efficacy of pharmacological treatment in spinal injury during the acute phase, systematic use of pharmaceutical agents should be reconsidered.

Acute Disease↗
PubMed2000

[Postoperative compressive spinal epidural hematomas. 15 cases and a review of the literature].

PURPOSE OF THE STUDY: In the literature, the frequency of postoperative compressive spinal epidural hematomas (SEH) appearing very low, we conducted the present study to determine the frequency of this complication in their unit and look for causative and predisposing factors. MATERIAL AND METHODS: Among the 1,487 spinal operations performed in our unit between September 1997 and August 1998, fifteen patients had postoperative compressive SEH; their files were retrospectively analyzed regarding the initial intervention, postoperative period, revision operation and neurologic follow-up. RESULTS: Five women and ten men were involved ranging in age from 47 to 70 years (average, 59.5 years). The primary intervention concerned the cervical spine in one case, the thoracic spine in seven and the lumbar spine in seven. Ten of the fifteen cases including all seven of the thoracic SEH (performed for compressive metastatic epiduritis) involved a laminectomy. A stenotic canal was the indication for the primary intervention in six of the seven lumbar cases. The average delay before onset of symptoms was 1.5 hours, 3.7 hours, and 5.3 hours after the cervical, thoracic, and lumbar interventions, respectively. The clinical pattern began with segmental pain rapidly followed first by bilateral radicular sensory deficit, then unilateral or bilateral motor deficit, except in the patients with thoracic SEH in whom segmental pain was followed by signs of cord impingement. Excluding the four cases in which diagnosis was retarded by work-up examinations (3 cases) or a misleading picture (1 case), revision surgery was performed from 1.25 to 4 hours after onset of symptoms (average, 2.75 hours). In the patients for whom reoperation was delayed, SEH resulted in permanent complete paralysis or sphincter dysfunction. In contrast, eight of the ten patients who were reoperated within four hours of the onset of symptoms either recovered completely or recovered their former neurologic status. DISCUSSION: Compressive SEH after spinal surgery is rare, only 41 cases having been reported aside from the series of Deburge et al. In the literature, the frequency is around 1 to 2 for 1000 operations for some authors, as opposed to 3 p. 100 and 6 p. 100 found by two other groups. The 1 p. 100 of the present series is close to the latter values. Nonetheless, it is probably important to take the type of surgery into account, as shown by the current series in which SEH occurred after 5.9 p. 100 of the operations for metastasis, but only once out of 304 anterior cervical interventions. To reduce the risk as much as possible, it is important to be aware of the factors that may contribute to this complication. Several recommendations concerning prevention of SEH are thus discussed. Once SEH has occurred, the only modifiable prognostic factor appears to be the delay before reintervention. CONCLUSION: Although postoperative SEH is relatively rare, it may have dramatic consequences. In our opinion, reintervention must be performed as soon as possible after the onset of neurologic deficit, the work-up investigations only prolonging the critical surgical delay, which is probably the only alterable prognostic factor.

Aged↗
PubMed2000

[Neurofibromatosis of the lower cervical spine: an operative case report].

PURPOSE OF THE STUDY: We report a case of type 1 neurofibromatosis (von Recklinghausen's disease) of the lower cervical spine in a 13-year-old girl. CASE REPORT: There was no neurological deficit. Plain films showed dysplastic 82 degrees kyphosis centered on the C4-C5 disc. Surgical treatment consisted in anterior multilevel interbody grafting and plate osteosynthesis combined with posterior arthrodesis. Good bone fusion was obtained with acceptable cervical mobility. The residual cervical kyphosis was 18 degrees. DISCUSSION: An evaluation of the cervical spine should be proposed for patients with neurofibromatosis even if there is no thoracic scoliosis. Severe cervical deformities can lead to serious neurological complications. Circumferential arthrodesis appears to provide optimum results.

Adolescent↗
PubMed1999

[Evaluation of the efficacy of foraminal infusions of corticosteroids guided by computed tomography in the treatment of radicular pain by foraminal injection].

PURPOSE: To evaluate the efficacy of foraminal steroid injections performed under CT guidance for the management of radicular pain. METHODS: Periganglionic infiltrations were performed in 160 patients with radicular pain refractory to medical treatment. Imaging showed either degenerative foraminal stenosis, herniated disk or postsurgical fibrosis. RESULTS: 102 patients (63.8%) had significant pain reduction. Pain relief was lasting in 68 (66.6%). CT showed the position of the needle tip, as well as the diffusion of the therapeutic compounds. CONCLUSION: We consider that CT-guided periganglionic steroid injections should be an integral part of the management strategy for radicular pain resistant to medical treatment.

Adrenal Cortex Hormones↗
PubMed1998

Reduction technique for uni- and biarticular dislocations of the lower cervical spine.

STUDY DESIGN: A technical report concerning the methods of reduction of dislocations of the lower cervical spine used in 168 consecutive cases (77 unilateral and 91 bilateral dislocations). OBJECTIVES: To evaluate the efficacy of a reduction protocol comprising three successive phases: reduction by traction, reduction by closed maneuvers with the patient under general anesthesia, and open reduction. SUMMARY OF BACKGROUND DATA: Management of cervical dislocations varies greatly among spine treatment centers, especially concerning the upper limit of traction, the safety of closed manipulations in anesthetized patients, and the approach preferred when surgical reduction is necessary. METHODS: Reduction by gradual traction without anesthesia was attempted first. In case of failure, specific closed manipulations were used with the patient under general anesthesia just before anterior arthrodesis was performed. If this failed, anterior surgical reduction was attempted. Anterior fusion was performed in every patient, even when closed reduction was successful, because of the lasting instability produced by attending ligamentous lesions. RESULTS: Of the patients in 168 cases of dislocation, the protocol failed in 5, all of whom had longstanding unilateral dislocation. Of the 91 with bilateral dislocation, reduction was achieved by simple traction in 39 (43%), by maneuvers with the patient under general anesthesia in 27 (30%), and by anterior surgery in 25 (27%). Among the patients in 77 cases of unilateral dislocation, reduction was achieved by traction in 18 (23%), by external maneuvers in 28 (36%), and by anterior surgery in 26 (34%). In 7 patients, discal herniation engendering neurologic signs was resected during anterior surgery. No neurologic deterioration during or immediately after reduction by this protocol was observed. CONCLUSIONS: This protocol consists of application of rapidly progressive traction, followed if necessary by one or two reduction maneuvers with the patient under general anesthesia. If both methods fail, specific surgical procedures using an anterior exposure seem to be reliable, in that anatomic reduction was obtained in 163 of 168 patients without neurologic deterioration.

Adolescent↗
PubMed1998

Complications of vertebral metastasis surgery.

The authors report their experience concerning complications of spinal metastasis surgery. The purpose of this study was to assess the frequency of such complications and analyse the factors influencing their occurrence. The records of 145 patients treated between 1982 and 1991 for metastatic disease of the spine were retrospectively reviewed for intra- and postoperative complications. Other factors such as radiation therapy, emergent nature of surgery, and neurologic deficits were analysed for potential correlations with the frequency of complications. Twenty-seven (18.6%) patients developed postoperative complications. Wound dehiscence and infection (11%) were the most frequent complications. Statistical analysis showed a significant influence of three factors: preoperative radiation therapy, paraplegia before surgery, and surgery under emergency conditions. The rate of complications in this surgery is lower than might be expected and can be significantly reduced. Surgery should be performed before radiation therapy and before appearance of substantial neurologic deficits.

Combined Modality Therapy↗
PubMed1998

[Medical treatment of spinal cord injury in the acute stage].

OBJECTIVES: To evaluate the effect on neurologic outcome and the safety of nimodipine (N), methylprednisolone (M), or both (MN) versus no medical treatment (P) in spinal cord injury at the acute phase. STUDY DESIGN: Prospective, randomized clinical trial. PATIENTS: One hundred and six patients with a spinal trauma, including 48 with paraplegia and 58 with tetraplegia. METHOD: After eligibility, patients were randomly allocated in one of the following groups: M = methylprednisolone 30 mg.kg-1 over 1 hour, followed by 5.4 mg.kg-1.h-1 for 23 hours, N = nimodipine 0.015 mg.kg-1.h-1 over 2 hours followed by 0.03 mg.kg-1.h-1 for 7 days, MN or P. Neurologic assessment (ASIA score) was performed by a senior neurologist before treatment and at the 1-year follow-up. Early spinal decompression and stabilization was performed as soon as possible after injury. RESULTS: One hundred patients were reassessed at the 1-year follow-up. Neurologic improvement was seen in each group (P < 0.0001), however no neurologic benefit from treatment was observed. Infectious complications occurred more often in patients treated with M. Early surgery (49 patients), within the first 8 hours did not influence the neurologic outcome. The only predictor of the latter was the extent of the spinal injury (complete or incomplete lesion). CONCLUSION: Currently, no evidence of the benefit of medical treatment in this indication is existing. Because of the lack of clinical studies proving efficacy of pharmacological treatment in this specific pathology, a systematic use of medications cannot be recommended.

Acute Disease↗
PubMed1997

A novel paraspinal surgical approach for lumbar lateral extraforaminal root entrapment.

We describe a new surgical route that we call the "crest approach" for treating extraforaminal disc herniation in the lumbar spine. This approach is useful only for the levels above L5-S1. It permits perfect root decompression without any bony resection that would contribute to instability. Muscle retraction and devascularization are reduced. Risk of nerve root lesions is minimal since the herniation is removed before root mobilization. Fifteen patients have been treated using this procedure. In all 15, pain and/or neurologic deficits remitted rapidly with no postoperative complications. In conclusion, the crest approach provides highly satisfactory operating conditions by simplifying exposure and greatly limiting the risk of complications. In our relatively limited experience using this procedure, only satisfactory results have been observed.

Adult↗
PubMed1996

[Spontaneous vertebral pseudarthrosis in ankylosing spondylitis. Apropos of 3 cases].

PURPOSE OF THE STUDY: The authors describe the surgical treatment of three cases of vertebral pseudarthrosis in two patients suffering from rheumatoid spondylitis for an average of 20 years. MATERIAL: Two pseudarthrosis involved the thoracic level (T9-T10 and T10-T11), after an insignificant trauma. In the other case, the lesion was a secondary localization (L5-S1) arising spontaneously two years after the treatment of a T10-T11 lesion. Initial conservative treatment was unsuccessful in all three cases. Anterior surgery was performed in all three cases. In two out of the three, posterior surgery was associated with the anterior approach. RESULTS: After surgery, the three lesions healed. DISCUSSION: Extensive discovertebral lesions during the course of rheumatoid spondylitis are well known. The authors discuss the pathophysiological mechanisms, the diagnostic difficulties of such lesions in patients referred for chronic spinal pain, and the choice of treatment. CONCLUSION: Surgical treatment was considered necessary in view of the mechanical solicitations of the mobile segment. A double approach, both anterior and posterior, gave good results and is advocated by the authors.

Adult↗
PubMed1995

Anterior discectomy without interbody fusion for cervical disc herniation.

Between 1985 and 1990, 68 patients with cervical radiculopathy due to soft disc herniation were treated by anterior cervical discectomy without interbody fusion. Eleven patients were unavailable for follow-up examination. The mean follow-up was 23 months (range 12-54 months). Both clinical and radiographic follow-ups were done, and 92% of the patients was found to have excellent or good clinical results. Radiographic follow-up revealed that 34% had fused spontaneously and 66% developed fibrous healing of the disc space with an average range of mobility of 2.07 deg. All patients were shown to be stable on flexion-extension films. Complications included two transient CSF leaks. No neurologic deficits arose. One patient was reoperated and fused for intractable residual neck pain. We conclude that anterior cervical discectomy without interbody fusion is a simple, safe and effective procedure for patients with soft disc herniation.

Adult↗
PubMed1995

Mean term follow-up of a series of post-traumatic syringomyelia patients after syringo-peritoneal shunting.

We report the follow-up of a series of post-traumatic syringomyelia patients treated by syringo-peritoneal shunting (SPS). The neurological status was determined following the international ASIA/IMSOP standards for neurological classification of spinal cord injury; this was completed by a modified Silberstein classification that identifies the ascending neurological symptoms as well as the increasing myelopathic symptoms in patients with post-traumatic syringomyelia. Magnetic resonance imaging (MRI) was systematically performed to assess the presence of a postoperative residual syrinx or of meningeal fibrosis. Eight patients were studied (five men, three women) with an age ranging from 17 to 54 years (mean of 30.7 years) at the time of the spinal cord injury. Three had a complete or nearly complete paraplegia, five were incomplete. The post-traumatic syringomyelia was diagnosed from 2 to 8 years after the spinal cord injury and was treated by syringo-peritoneal shunting. Early complications occurred in three patients: (1) displacement of the catheter, (2) obstruction of the catheter, and (3) haematomyelia, which disappeared after a new surgical procedure was performed. The postoperative follow-up ranged from 3 to 9 years (mean of 4.5 years). The neurological level decreased in every case and the ascending neurological symptoms decreased or were stabilised in seven patients. The postoperative ASIA/IMSOP scores and the increasing myelopathic symptoms improved in four patients but worsened in the four others, incomplete. The MRI showed an important decrease of the syrinxes in every patient associated with a serious meningeal fibrosis in five cases. Syringo-peritoneal shunting seems to be efficient in the treatment of the syrinx but may have a poor effect regarding the prevention of meningeal fibrosis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1995

Thoracic spinal trauma and associated injuries: should early spinal decompression be considered?

The relative benefits of conservative or surgical treatment in thoracic spinal trauma are still controversial. Owing to its anatomic relations, thoracic spinal trauma is specific regarding neurologic prognosis, the high incidence of associated injuries, and surgical management. Over a 30-month period, 49 patients sustained thoracic spinal trauma with neurologic impairment. The authors review population characteristics, associated injuries, and surgical management, and underline the high incidence of associated injuries, in particular, blunt chest trauma. In their opinion, early spinal decompression has no indication in complete paraplegia. Concerning partial paraplegia, early surgery may enhance neurologic recovery. Nevertheless, they suggest three main criteria in deciding whether or not to perform surgery early: the existence of residual spinal compression, the degree of neurologic impairment, and the presence of potential hemorrhagic lesions or blunt chest trauma, especially pulmonary contusion.

Adolescent↗
PubMed1994

Odontoid fractures. Review of 150 cases and practical application for treatment.

A total of 150 odontoid fractures was treated over a 12-year period, 43 by anterior screw fixation. The rate of pseudarthrosis dropped from 20% to 5% in type II unstable fractures. Thus, anterior screw fixation seems to be safe and efficient, and may be more widely used to treat all type II and some type III fractures. Odontoid pseudarthrosis is usually tolerated quite well and therefore requires no correction. If necessary, anterior grafting with fixation can be proposed as an alternative for posterior fusion.

Bone Screws↗
PubMed1994

Long-term results of cervical epidural steroid injection with and without morphine in chronic cervical radicular pain.

To evaluate the long-term effectiveness of a single cervical epidural steroid injection (CESI) performed with or without morphine, 24 patients, without need of surgery, but suffering for more than 12 months from cervical radicular pain, were included in a prospective and randomised study. The cervical epidural space was injected (C7-D1; 18-ga needle) with an increasing volume (10 ml maximum) of isotonic saline solution to exacerbate the patient's radicular pain. The patients were then randomly allocated to 2 groups: the steroid group (group S, n = 14) received an equivalent volume of 0.5% lidocaine plus triamcinolone acetonide (10 mg/ml) and the steroid plus morphine group (group S + M, n = 10) received the same combination plus 2.5 mg of morphine sulphate. Pain relief was assessed as the percentage of pain decrease on a visual analogue scale on day 1 and at months 1, 3, 6, 8 and 12 after CESI, up to 48 months. Anthropometric data between the 2 groups were similar. The mean volume injected in the epidural space was: 6.6 +/- 2.1 and 6.3 +/- 1.9 ml in groups S and S + M, respectively, and this volume exacerbated pain in 21 of 24 patients. Despite observing a better transient improvement the day after CESI in the S + M group, long-term results did not differ. The success rate was 78.5% in group S and 80% in group S + M providing pain relief of 86.8 +/- 14.7% and 86.9 +/- 17.9%, respectively. Pain relief remained stable with time (mean follow-up: 43 +/- 18.1 months).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗