PubMed Health⌕ Search

Biomedical subjects

V R Kodali

Publications and source records attributed to V R Kodali.

13 recordsLinked to original sources
PubMed1997

Body mass index and family histories in type II diabetic propositi and preliminary observations on the transmission of diabetes in polygamous families.

We studied family histories of diabetes mellitus in the first-degree relatives of 356 type II diabetic propositi in whose families monogamy is practiced. Positive family histories were noted in 32% of the propositi: parental 20%, sibling 14%, and offspring 0.6%. In 11 pedigrees with conjugal diabetic parents, 33% (18/55) of their offspring were diabetic. Paternal influence was significantly higher than maternal influence (43 of 62 vs. 19 of 62, Z = 2.86, p < 0.01). The presence or absence of sibling history did not depend on the body mass index in the propositi. We also studied pedigrees of 10 propositi in whose paternal families polygamy is practiced. In these families also a trend toward greater paternal influence was noted. We conclude that (1) a family history of diabetes is present in one-third of diabetic propositi, (2) paternal influence is stronger than maternal influence in the transmission of diabetes, (3) sibling history for diabetes has no relation to the body mass index of the propositi, (4) prevalence of diabetes is higher in the offspring of conjugal diabetic parents, and (5) studies in polygamous families are a new approach that may help to quantify the genetic load transmitted from a parent when there is heterogeneity in the spouses.

Adult↗
PubMed1993

Poor cognitive task performance of insulin-dependent diabetic children (6-12 years) in India.

UNLABELLED: Cognitive function was assessed in 22 diabetic and 39 healthy children, all in the age group of 6-12 years. Wechsler's coding, digit span test and Raven's colored progressive matrices were included in the battery of tests. The diabetic children underscored on all these tasks compared to the healthy children. The raw scores (mean +/- S.D.), of the diabetic and healthy children were: Wechsler's coding: 17.4 +/- 6.48, 37.4 +/- 9.33; digit span: 22.0 +/- 8.8, 44.1 +/- 7.67 and on Raven's A+AB+B: 16.2 +/- 3.5. 24.1 +/- 6.26; P < 0.001 in each instance, respectively. Duration of diabetes did not correlate with any of the test scores. No significant differences were noted between the early onset (IDDM starting before the age of 5 years) and late onset (IDDM starting after 5 years) diabetic children in their performance. We attribute the very low scores in our diabetic children to the psycho-social factors in addition to the metabolic control. CONCLUSIONS: (1) specific cognitive dysfunction is present in children with IDDM compared to the healthy children; (2) duration of diabetes did not correlate with cognitive function scores; (3) IDDM manifesting after the age of 5 years also had hitherto unknown detrimental effects on the cognitive process.

Age of Onset↗
PubMed1990

Epidemiology of diabetes in Asians of the Indian subcontinent.

Asians from the Indian subcontinent have received greater attention in diabetes studies because of their migration in large numbers. The prevalence of non-insulin-dependent diabetes mellitus (NIDDM) in migrant Indians is higher than that in the population residing in the Indian subcontinent and is also usually higher than in the other racial groups in the host country. However, before drawing any conclusions with reference to the high prevalence of NIDDM in the migrant Indians, careful comparisons are required with more up-to-date information available from the Indian subcontinent itself. Recent data from India indeed indicate that the prevalence rates have either been underestimated in the past or are rising. The problem is compounded by the different diagnostic criteria used for defining diabetes. Some of the possible factors which cause variations in the rates of NIDDM in this population are discussed.

Diabetes Mellitus↗
PubMed1990

Gender differences in the associated complications among type-II diabetics with peripheral neuropathy.

Diabetic neuropathy is an intriguing problem both for the patient and the clinician, however the clinical characteristics of type-II (non insulin-dependent) diabetics with peripheral neuropathy with special reference to gender differences is not paid much attention. We studied peripheral neuropathy and related complications in 179 type-II diabetics. Peripheral neuropathy was noted in 46 of 111 men and in 46 of 68 women. The age group of subjects did not differ significantly. Duration of diabetes differed between the groups with (n = 46) and without (n = 65) peripheral neuropathy (expressed in years and as mean +/- S.E: 7.7 +/- 0.7 vs 5.5 +/- 0.7; t = 2.2; P less than 0.05) in men, whereas in women it was not significant. Higher proportion (62.5% of 24) of men with proteinuria had neuropathy. Similar findings in women were not different. We conclude i) a large percent (51.4%) of the type-II diabetics had peripheral neuropathy than realised ii) duration of diabetes and proteinuria are important risk factors associated with neuropathy especially in men and iii) the gender differences need further clinicopathologic evaluation.

Blood Glucose↗