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Biomedical subjects

V R Naik

Publications and source records attributed to V R Naik.

14 recordsLinked to original sources

Pancreatoblastoma: a rare tumour accidentally found.

A 15-year-old girl, who was previously well, complained of a mass in the abdomen after a minor motor vehicle accident. Physical and radiological investigations revealed a mass in the body of pancreas containing proteinaceous material and multiple nodules in both lobes of liver. Serological investigations for malignancy were normal. Histopathological examination of the resected specimen showed pancreatoblastoma. Pancreatoblastoma is an unusual malignant tumour seen in infants and children although rare cases have also been reported in adults. They are clinicopathologically distinct from adult pancreatic ductal carcinoma. The histogenesis, clinical features and treatment options are discussed along with presentation of the case.

Abdomen↗

Cucumis trigonus Roxb. II. Diuretic activity.

An alcoholic extract of Cucumis trigonus was studied for its diuretic activity in albino rats using hydrochlorothiazide as a standard drug for comparison. The extract exhibited a dose-dependent saliuretic effect reaching a peak at 4 hours. Unlike hydrochlorothiazide, the extract does not affect potassium excretion.

Animals↗

Analgesic and anti-inflammatory activity in alcoholic extracts of Cucumis trigonus Roxburghii. A preliminary communication.

Alcoholic extract of Cucumis trigonus was studied for analgesic activity by tail clip method in mice with pethidine hydrochloride as standard drug and by hydrochloric acid-induced writhing in mice using sodium salicylate as standard drug for comparison. ED50 of the extract was found to be 2.5 +/- 1.9 and 2.5 +/- 1.7 mg/kg in the two methods, respectively. Anti-inflammatory activity was studied in carrageenin-induced oedema and cotton pellet-induced granuloma using phenylbutazone as a standard drug for comparison. In both the methods the extract exhibited statistically significant activity.

Analgesics↗