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V Ranić

Publications and source records attributed to V Ranić.

15 recordsLinked to original sources

Bronchoscopy in the diagnosis and therapy of chest injuries.

Owing to its technical possibilities, bronchoscopy has also come into frequent use in the treatment of trauma patients, not only for diagnostic but also for therapeutic purposes. It has become a mandatory procedure in the treatment of chest injuries. Following discussion of its history, possibilities and scope, the authors present the results of treatment over the last two years at the University Hospital of Traumatology Zagreb, Croatia. There were 407 bronchoscopies performed in 157 trauma patients (on the average, 2.59 bronchoscopies per patient). According to indications for bronchoscopy, patients were classified into four groups: (a) patients with atelectasis (N = 51), with a total of 68 bronchoscopic procedures (1.33 per patient; (b) patients who developed infiltrates (N = 48) with 162 bronchoscopies (3.37 per patient); (c) patients with excessive secretions (N = 42) with 153 bronchoscopies (3.64 per patient); and (d) patients who developed respiratory insufficiency in the course of treatment (N = 16) with 24 bronchoscopic procedures (1.5 per patient). The best results were achieved in the atelectasis patients--in 74.47% of them there was no need of additional bronchoscopies, whereas in the group with excessive secretions or infiltrates bronchoscopy had to be repeated several times. It may be concluded that today, bronchoscopy is a routine diagnostic and therapeutic method in the treatment of chest injuries.

Bronchoscopy

[The role of proteins and amino acids in acute phase response].

The acute phase response after severe trauma leads to the major changes in synthesis and levels of plasma proteins. Activation of humoral cascade system and activity of phagocytes accelerates healing. In the prospective study the levels of serum total proteins and albumin in relation to acute phase proteins, fibrinogen and CRP were measured in the group of 34 severe traumatized patients, age 31.21 +/- 1.52 yrs submitted to the standardized ICU treatment. An increase in the levels of serum total protein from 51.07 to 52.53 g/l was registered during the first week. The levels of albumin were below 30 g/l for most of the patients during the entire two-week examination. The initial levels of albumin were 26.40 +/- 6.13 g/l and at the end of the examination 29.60 +/- 2.97 g/l (p = 0.008). The levels of fibrinogen showed the increase to 5.93 g/l during the entire examination. The rapid increase in the levels of CRP from 5 mg/l to 169.67 mg/l 48 hours after trauma and were still high at the end of examination 45 mg/l. That implies the activity of inflammatory mediators. The role and supplement of certain amino acids in maintaining the integrity of intestinal mucosa and immune system during the acute response to stress is discussed.

Acute-Phase Reaction

[Multiorgan dysfunction syndrome (MODS) caused by long bone fractures in young persons].

In a prospective open study, the effect of continuous epidural analgesia by the 0.5% bupivacaine-methadone mixture on the perfusion in the lower extremities was examined in a group of 34 patients (mean age 31.25-1.52 years). The patients were undergoing a standard intensive care treatment. The minimum analgetic dose was determined by means of an analogous-visual ten-point scale, and the minimum perfusion dose (MBD) by measuring the foot temperature on the injured side with electronic thermometer Genius 3000 (Sherwood, USA). Immediately, following the injury, the foot temperature on the involved side measured 27.40-2.20 (25.20-31.30) degrees C. The temperature differences between the injured and healthy foot were 5.92-2.19 degrees C, p = 0.0000. Forty minutes after the induction of epidural analgesia, the temperature of the injured foot increased to 32.44-1.75 degrees C, p = 0.0000. After 24 hours, it measured 32.44-1.27 degrees C, i.e. almost the same as in the healthy foot, with the auricle temperature being 36.20-1.62 degrees C. The total dose of methadone during the first 24 hours was 20 mg, and the 0.5% bupivacaine dose was 133.00-48.80 mg/24 hrs.

Adult