Biomedical subjects

V Reinhardt

Publications and source records attributed to V Reinhardt.

78 records · Page 5Linked to original sources

PubMedDate not supplied

Primary cerebral anaplastic T-cell-lymphoma (type Ki-1): review and case report.

We describe the clinical course of a 20-year-old man who suffered generalized convulsive seizures with postictal aphasia and hemiparesis of the right side. Computed tomography (CT) displayed a left postcentral lesion with prominent perifocal edema and only a little contrast medium enhancement. The completely removed tumor proved to be a primary cerebral non-Hodgkin lymphoma consisting of T-cells. Only ten days after the operation the patient once more presented a clinical deterioration. A nuclear magnetic resonance imaging (MRI) displayed an annular structure in the area previously operated upon, suspected to be an abscess. The second operation disclosed a large recurrence of the primary T-cell lymphoma extending diffusely into the white matter. On account of the rapid recurrence, a whole brain irradiation was started twelve days after the second operation. Four cycles of chemotherapy followed. Immunohistochemical studies of the anaplastic large lymphoma cells showed staining with the pan T-cell markers (UCHL1, CD3) and with the CD30 (Ki-1) antibody. The B-cell markers (L26, LN1) were negative. The EMA (epithelial membrane antigen) was only partially expressed. Further investigation excluded the presence of systemic lymphoma manifestation. 24 months after the last operation the patient remained free of symptoms. The last MRI displayed no evidence for the recurrence of a lymphoma. In reference to this unusual clinical course the few previously reported cases of the extremely rare primary cerebral T-cell lymphoma are reviewed.

Adult↗

PubMedDate not supplied

Rabies encephalitis: immunohistochemical investigations.

Three cases of human rabies encephalitis were studied immunohistochemically using a specific antiserum to rabies ribonucleoprotein (RNP) and the peroxidase-antiperoxidase method. In this way, RNP could be specifically demonstrated in all cerebral regions and the spinal cord with a predilection for virus attack on the diencephalon and the brain stem according to the clinical course of the disease, and possibly reflecting the phenomenon of pathoclisis. Virus antigen was mainly present in the nerve cell bodies and processes, and in glial cells, especially in the interfascicular oligodendroglia, which seems to be a route of rabies virus infection in the later course of this fatal disease. Immunohistochemically, virus antigen was not limited to the Negri bodies: it was also traceable in the cytoplasm. Altogether, many more virus infected cells were established by immunostaining than were to be expected by the presence of Negri bodies in hematoxylin-eosin stained sections.

Adult↗

PubMedDate not supplied

CT of carpal tunnel syndrome.

The carpal tunnel was investigated by high-resolution computed tomographic (CT) scanning of two cadavers, two healthy persons, and 20 patients with carpal tunnel syndrome to outline normal and pathologic anatomy. The following changes leading to median nerve compression in the carpal canal were demonstrated by CT: (1) thickening of the transverse carpal ligament with resultant decrease in the volume of the carpal tunnel, thus leading to compression of its contents; (2) synovial sheath "hypertrophy" of the flexor tendons, in which compression of the nerve seems to be caused by an increase in volume of the tissues within the carpal canal due to the thickened synovium around the flexor tendon; and (3) recurrent fibrosis after surgery.

Carpal Tunnel Syndrome↗

PubMedDate not supplied

Gliofibroma originating from temporoparietal hamartoma-like lesions.

Clinical and neuropathologic observations are reported of a 16-year-old girl with a right temporoparietal tumor. The histologic picture revealed cortical areas with a peculiar growth of neurons, glia or tumor cells, and strands of collagen following the pattern of the cortical architecture. In this area of hamartoma-like cortex a large tumor nodule was found with anaplastic cells in fibrous stroma exhibiting partially positive GFAP reaction. The picture closely resembles the features of a tumor described in 1978 by Friede in the medulla oblongata of a 3-year and 9-month-old girl. A comparison of histology and ultrastructure of both tumors is followed by discussion of the origin of this peculiar type of tumor, focussing on the existence of unusually pluripotent cells that may develop into glial and mesenchymal cells.

Adolescent↗

PubMedDate not supplied

Multiple sclerosis and cerebral tumor.

Two cases of long-standing multiple sclerosis (MS) are presented. During the course of this disease signs of a space-occupying lesion in the brain developed. An astrocytoma was diagnosed by biopsy in both patients. A later postmortem examination in one of them revealed a diffuse glioma with extension of tumor cells into the brain stem and cerebellum. Current opinions on the development of cerebral gliomatous tumors and of malignant lymphomas in patients with MS are discussed. Recent immunopathologic aspects are considered.

Adult↗

PubMedDate not supplied

Multiple intracerebral metastases of a 17-year-old girl with previously diagnosed neurofibromatosis type I.

We report a case of a 17-year-old girl with multiple intracerebral tumors. Previously, a neurofibroma in the posterior mediastinum and neurofibromatosis had been diagnosed. She developed a spastic tetraparesis with a prominent hemiparesis of the right side within several weeks. On admission we found clinical signs of elevated intracranial pressure. Cranial CT and MRI scans showed multiple space-occupying intracerebral tumors, thought to be multiple meningeoma. The patient was referred to the neurosurgical department, where two of the intracerebral tumors were excised. The histological examination revealed metastases of a neurosarcoma.

Adolescent↗