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Biomedical subjects

V Rhodes

Publications and source records attributed to V Rhodes.

9 recordsLinked to original sources
PubMed2001

Development of emission factors for polyamide processing.

Emission factors for selected volatile organic compounds (VOCs) and particulate material were developed during processing of commercial grades of polyamide 6, polyamide 66, and polyamide 66/6 resins. A small commercial-type extruder was used, and melt temperatures ranged from 475 to 550 degrees F. An emission factor was calculated for each substance measured and is reported as pounds released to the atmosphere per million pounds of polymer resin processed. Scaled to production volumes, these emission factors can be used by processors to estimate emission quantities from similar polyamide extrusion operations.

Air Pollutants↗
PubMed1994

Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma.

PURPOSE: To determine the activity and evaluate the toxicity of uracil and tegafur in a 4:1 molar concentration (UFT; Taiho Pharmaceutical Ltd, Tokyo, Japan) plus oral calcium leucovorin in the treatment of patients with advanced colorectal carcinoma. PATIENTS AND METHODS: Forty-five patients with advanced, bidimensionally measurable metastatic colorectal carcinoma were enrolled onto the trial. None of the patients had received prior chemotherapy or biologic therapy for advanced disease. Patients received either 350 or 300 mg/m2/d UFT plus 150 mg/d leucovorin administered orally in divided daily doses every 8 hours for 28 days followed by a 7-day rest period. Response was evaluated after two courses of therapy. RESULTS: Eighteen patients (three treated at 350 mg/m2/d and 15 at 300 mg/m2/d) had partial responses, and one patient had a complete response (response rate, 42.2%; 95% confidence interval, 28% to 58%). Responses were observed in sites that included liver (n = 18), lung (n = 6), and bone (n = 1). Of seven patients who received 350 mg/m2 UFT, prolonged grade 3 diarrhea developed in five; this resulted in a reduction in the UFT starting dose to 300 mg/m2/d in the remaining 38 patients. Grade 1 or 2 toxic effects included diarrhea, nausea, vomiting, abdominal cramping, anorexia, fatigue, oral mucositis, excessive lacrimation, and rash. Among 38 patients who received the 300-mg/m2/d dose, grade 3 toxic reactions included diarrhea (n = 4), vomiting (n = 2), abdominal cramping (n = 1), and fatigue (n = 2). CONCLUSION: UFT 300 mg/m2/d plus oral leucovorin 150 mg/d administered for 28 days demonstrated significant activity against metastatic colorectal carcinoma. This oral regimen was well tolerated and devoid of the neutropenia or significant oral mucositis that complicates intravenous schedules of fluorouracil (5-FU) plus leucovorin. The results of this clinical trial will serve as the basis for a randomized phase III study to compare this oral schedule of UFT plus leucovorin with intravenous 5-FU plus leucovorin to determine the relative efficacy, impact on quality of life, and cost of the two regimens.

Administration, Oral↗
PubMed1993

The grief process and job loss: a cross-sectional study.

This study assessed the applicability of the grief process to job loss. A pilot study of 10 unemployed men was used to establish a structured interview, and its content analysis, based on a description of the grief process derived from studies of bereavement. Other measures assessed the degree of attachment to the former job. The main study involved 60 men who had lost their jobs during the previous eight years. Individual grief items were found in some of these people, varying in frequency from 10 to 80 per cent. Principal components analysis revealed a general grief component, representing most of the specific items. Twenty-seven per cent of the sample fulfilled a criterion for a clear grief-like response. An overall grief score based on the interview answers was significantly correlated with three different measures of job attachment, and also with questionnaire measures of depression and anxiety. These measures were unrelated to the length of time since job loss, apparently providing no support for stage theories or for more general assumptions of adaptation. However, the cross-sectional nature of the sample complicates this conclusion.

Adaptation, Psychological↗
PubMed1987

Bereavement and reactions to job loss: a comparative review.

An assessment is made of the applicability of the grief framework for understanding reactions to job loss. Jahoda's 'deprivation view' of unemployment is introduced as a statement of what is lost, with the grief model describing the process of adjustment to loss. The main features of grief are described: it is an active process, changing over time, consisting of a number of episodic components combined with a background of chronic emotional disturbance. Parkes' concept of psychosocial transitions is then outlined; this provides a theoretical link between grieving and reactions to other forms of loss, including job loss. An assessment is made of how the grief process has been applied to job loss in existing research. Evidence for most of the components of the grief process is apparent in accounts of reactions to unemployment, but there is little evidence on their frequency, changes over time or their relationship to one another. Variables which are likely to affect the occurrence, extent and precise course of any grief-like process are examined by comparing reactions to bereavement and job loss. The family and social contexts of reactions to loss are then considered in relation to both grief and unemployment. Finally, the advantages and limitations of the grief model are briefly discussed.

Employment↗
PubMed1981

The Hemo Hotline.

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Communication↗