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Biomedical subjects

V Roman

Publications and source records attributed to V Roman.

At least 37 records · Page 2Linked to original sources
PubMed1984

A study of the mechanism of cerebral hyperexcitability after irradiation.

Whole-body irradiation at a lethal dose induced an early and transient perturbation of 3H-Muscimol specific binding in the mouse cerebellum. The density of high affinity binding sites was decreased and was associated with an increased affinity. This effect can explain early radio-induced cerebral hyperexcitability. Previous injection of cysteamine, which protects against cerebral hyperexcitability, also offers a good protection against this effect.

Animals↗
PubMed1982

[Radioprotective effect of cysteamine entrapped in liposomes orally administered to the mouse].

Cysteamine entrapped in liposomes was orally delivered to Mice and its radioprotective effect observed as a function of the time elapsed between its administration and 60Co gamma irradiation. A protection is manifest up to 3 hrs after administration. This result contrasts with the absence of protection afforded by cysteamine when orally given as an aqueous solution, and with the short lasting activity of its parenteral administration.

Administration, Oral↗
PubMed1978

Bone and joint changes in lower limb amputees.

A clinical and radiological survey of bone and joint changes in 42 lower limb amputees is reported. There was a significant increase in osteoarthrosis in the knee of the unamputated legs compared with the amputated side. The amputated side characteristically showed osteoporosis. Comparing the prevalence of osteoarthrosis in this study with figures in the population, it is more likely that the osteoporosis of the amputated limb had a protective effect on that side than that mechanical factors produced more osteoarthrosis on the contralateral side. Backache occurred in about half the patients, and was severe in 19%. It did not appear to be related to disc degeneration, but scoliosis was observed in 64% of patients.

Adult↗
PubMedDate not supplied

Electroclinical correlations in temporal lobe epilepsy.

2,698 epileptic patients were studied, 2,019 cases (64.3%) presenting temporal lobe epileptic attacks. Besides the routine EEG recordings and the corroboration of the clinical data with the meticulous observations by video monitoring on a closed circuit TV-screen (the patients being observe in a specially arranged room, provided with infra-red cameras), the diagnostic procedure was supported in all cases by several computerized EEG mappings, according to a model achieved by us, transcribing the primary data obtained by Hjorth's NSD parameters from the Siemens-Elema Mingograph to a Romanian M-118 microprocessor. In many cases we utilized an interface--built by us--for analog-digital conversion which allowed the direct introduction and conversion of amplitudes and frequencies from the Mingograph to the micro-computer. These were isolated to analyse the following electroclinical forms: 1. temporal absences: 360 cases (17.8%); 2. psychomotor attacks: 439 cases (21.7%) 3. psychosensory attacks: 77 cases (3.8%); 4. attacks with cognitive symptomatology: 260 cases (12.8%); 5. crises with ideative-affective symptomatology: 76 cases (3.8%); 6. vegetative attacks: 51 cases (2.5%); 7. akinetic attacks: 89 cases (4.4%); 8. focal temporal attacks secondarily generalized: 667 cases (33.0%). In 112 patients with nocturnal attacks, polysomnographic recordings were performed with sequential computerized EEG mappings during the various stages of sleep (concomitantly with the infrared video-TV monitoring).

Adult↗
PubMedDate not supplied

Polysomnographical researches in patients with temporal lobe epilepsy.

One hundred and twelve patients with temporal lobe epilepsy were studied. Continuous polysomnographical recordings were performed for eight hours, the patients being video-monitored all the time. These researches, completed with computerized EEG cortical mappings demonstrated a peculiar activation of the temporal foci during REM phases and during some stages of LSWS.

Brain Mapping↗
PubMedDate not supplied

Spectral analysis of Doppler signal in the prophylaxis of ischemic cerebrovascular accidents in extra- and/or intracranial carotid and vertebral systems.

Using continuous-wave spectral analysis of Doppler signal (SADS) and/or pulsed-wave transcranial Doppler ultrasonography (TCD-US) we examined 263 patients with ischemic cerebrovascular diseases (ICVD) symptoms in the carotid and vertebrobasilar (V-B) systems. The degree of stenosis was established by taking into consideration the parameters of the spectrum of frequency (systolic peak velocity--SV; end-diastolic velocity--DV); the ratio between SV of internal carotid artery (ICA) and common carotid artery (CCA); the ratio between DV of ICA and CCA as well as the value of the spectral broadening (SB) index. The diminution of DV in CCA with increased values of Pourcelot's circulatory resistance index (RP) and spectral broadening index (SB) as compared with the controlateral part, but with apparent increase (over 3.5 kHz) of SV in ICA was constantly observed in significant stenoses of extracranial ICA. Our observations have pointed out that when proximal ICA occlusion is being formed slowly and progressively, ECA (whose increased circulatory resistance under normal conditions reflects diminished diastolic velocities) gradually takes over the hemodynamic characteristics of ICA which is expressed by increased DV, approximating DV and ICA. This situation may give rise to erroneous interpretations.

Blood Flow Velocity↗
PubMedDate not supplied

Polysomnographic and computerized waking-sleep research in epileptic petit mal absences.

The authors carried out 8 hours of continuous night polysomnographic recordings in 40 selected cases with various forms of absences. In all these patients, the computerized electroencephalographic mappings were performed according to several methods achieved by the authors. The nocturnal electrographic abnormalities, the morphological patterns of the epileptic discharges during different sleep stages and the cortical computerized cartography were comparatively analysed in the five groups of patients: 1) genuine (pure, classical or simple) petit mal (PM) absences: 8 cases; 2) myoclonic PM absences: 10 cases; 3) amyotonic-akinetic PM absences: 6 cases; 4) "false" temporal epileptic absences: 10 cases; 5) "hybrid" (or "bastard") PM absences in 6 cases with Lennox-Gastaut disease.

Diagnosis, Computer-Assisted↗