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Biomedical subjects

V Rossa

Publications and source records attributed to V Rossa.

14 recordsLinked to original sources
PubMed1992

[Risk factors for fibrinoid reaction after posterior chamber lens implantation--a retrospective study].

Previous ocular diseases (e.g. herpetic keratouveitis), glaucoma, previous ocular surgery and surgery longer than normal turned out to be the main risk factors for a fibrinoid reaction after an extracapsular cataract extraction with posterior chamber lens implantation in patients of the Universitäts-Augenklinik Düsseldorf between June 1989 and March 1990. This result was obtained from a retrospective study of the medical records. No special risks could be concluded neither from the presence of general diseases (e.g. diabetes mellitus, consumptive basic diseases), immuno-suppressive treatment, constitutional factors, nor from age, sex, operative method nor from the surgeon. Preoperative antiexsudative prophylactic treatment is suggested for patients with one or more risk factor.

Adult↗
PubMed1991

[Clinical follow-up, histologic findings and therapeutic problems in a patient with bilateral ulcus rodens Mooren].

A severe, spontaneously acquired, bilateral, sight threatening Ulcus rodens Mooren of a 31 years old type I diabetic will be demonstrated in its clinical course. An improvement was achieved by a systemic immunomodulating therapy with Ciclosporin A that had to be tapered after 3 weeks due to severe side effects. The exclusive local therapy showed no effect at all. Later, the patient underwent a penetrating keratoplasty and extracapsular cataract extraction of both eyes under systemic Ciclosporin A therapy. The graft of the left eye failed due to a foudroyant bacterial infection whereas the keratoplasty of the right eye was successful up to this day despite of various complications.

Adult↗
PubMed1991

[Local prevention with interferon of "epidemic" conjunctivitis caused by a currently unidentifiable virus].

Topical Interferon application did effectively interrupt the further clinical spread of a highly contagious viral keratoconjunctivitis. A total of 130 endangered inpatients, still free from symptoms, were treated with one drop per eye daily for a period of 12 days. 123 patients stood free from any further infection. Only during the first two days after the beginning of the Interferon prophylaxis 7 inpatients showed an acute viral keratoconjunctivitis still. Obviously these patients were infected prior to the prophylactic therapy and were just in the incubation period. We conclude that Interferon eye drops (one drop per eye daily) may offer a reliable protection from exogenous viral infection. Certainly this protection comes too late if the patient's incubation period has already started.

Adenovirus Infections, Human↗
PubMed1991

[Contusion-induced traumatic aniridia].

Total aniridia occurred after a severe blow on the eyeball of a 65 year old man. The entire iris was torn off the ciliary body and escaped out of the eye through a small corneal wound. The zonular fibres were found to be intact and the posterior parts of the eye showed no traumatic changes.

Aged↗
PubMed1991

[Retinal changes in Wilson's disease].

Increasing loss of vision caused by peculiar macroscopic and functional retinal changes was the first ophthalmologic manifestation of Wilson's disease in a 22-year-old patient. Neither retinal changes nor great visual impairment has been described thus far in the literature concerning this disease. Likely correlations are discussed with Menkes syndrome, an X-linked inborn error of copper metabolism with onset in early childhood.

Adult↗
PubMed1990

[Preventive systemic cyclosporin A in risk keratoplasty].

Systemic cyclosporin A prophylaxis was applied in 18 high-risk corneal transplants. Immunoreactions occurred in three cases. They correlated with too low serum level of cyclosporin A. Two of them could be reversed by an increase of cyclosporin A dosage in combination with an intensive corticosteroid therapy. Four corneal transplants failed from persistent severe basic disease. Eleven corneal transplants remained clear during the follow-up (5-33 months). A constant trough cyclosporin A serum level of 100-120 ng/ml has been shown to exert efficient immunomodulating effects. We currently judge a postoperative prophylaxis period of 6 to 12 months with cyclosporin A to be sufficient in most high-risk cases.

Administration, Oral↗
PubMed1990

Effect of ethylene glycol on rabbit retinas.

Electrophysiological and histological changes in rabbit retinas were induced by the oral application of ethylene glycol. The electroretinogram revealed a reduced photopic and scotopic activity. Birefringent crystalline deposits were found predominantly in the ganglion cell layer and the inner nuclear cell layer of the retina. These retinal findings were associated with depositions of calcium oxalate crystals in the rabbit kidney and liver.

Administration, Oral↗
PubMed1989

[Initial manifestation of sarcoidosis as a palpebral and para-bulbar tumor].

Tumors of the lids, the lacrimal gland and the orbit can be early manifestations of sarcoidosis. A timely diagnosis based on biopsy of periocular tissues and cinico-radiographic evaluation at an early stage of the disease may prevent irreversible lesions of the parenchymatous organs. The clinical and histological signs in two patients, one with palpebral and one with parabulbar sarcoidosis, are described and the differential diagnosis and therapeutic aspects are discussed.

Aged↗
PubMed1987

[Significance of an angiogenic factor (in omental lipid) for the vascularization of the cornea].

The existence of an angiogenic factor in the omental lipid was verified by injecting four different test materials in dosages of 50 microliters into the corneas of New Zealand rabbits. The test substances were: 1) phosphate-buffered saline solution; 2) chloroform-methanol solution; 3) phosphate-buffered saline homogenate of the chloroform-methanol extract of the lipid cake from the rabbit omentum. The experimental results show that the modes of neovascularization after injection of lipid and nonlipid materials into rabbit corneas are very similar. For angiogenesis to be stimulated, the noxious substances must be retained in the cornea for several days. One day after injection the phosphate-buffered saline solution is totally resorbed. The other test substances (2-4), are retained within the cornea for days or weeks. Test substance 1 does not induce any corneal vascularization. The injection of test substances 2-4 causes similar corneal neovascularization: the proliferation of vessels always starts from that segment of the limbus closest to the stimulation. Since the extent of vascularization after injection of chloroform-methanol solution alone is similar to that which occurs after injection of an omental lipid extract, the hypothesis of a specific angiogenic factor is not supported. Fluorescein angiography reveals a large outflow of fluid (leakage) out of the neovascularization.

Angiogenesis Inducing Agents↗
PubMed1987

[Electrophysiologic and histologic retinal changes after diethylene glycol administration].

The toxic effect of diethylene glycol on the retina was studied in white New Zealand rabbits. In a three-month study diethylene glycol dissolved in water was administered orally to groups of four rabbits at dose levels of 0 (control) and 4%. The ERG revealed a dose-dependent prolongation of the b-wave and a reduction in the photopic amplitudes of the a- and b-waves. In agreement with the electrophysiological findings the histologic study of the retina showed birefringent crystals predominantly in the inner nuclear cell layer. Oxalate seemed to be a metabolite of diethylene glycol, because aggregations of calcium oxalate crystals were deposited in the kidneys and livers of the animals.

Animals↗