Biomedical subjects

V Rummelt

Publications and source records attributed to V Rummelt.

41 records · Page 3Linked to original sources

PubMed1990

A 32-year follow-up of the rigid Schreck anterior chamber lens. A clinicopathological correlation.

We describe the clinicopathological findings in an eye after 32 years of successful anterior chamber lens implantation. In 1956, a rigid Schreck total polymethylmethacrylate anterior chamber lens was implanted in the right eye of a 28-year-old white man 1 year after corneo-scleral laceration with traumatic cataract. The postoperative clinical course was subjectively unremarkable for at least 30 years. In 1988, the patient developed secondary angle closure glaucoma, associated with a cavernous Schnabel optic atrophy that was caused by peripheral anterior synechiae and fibrovascular downgrowth into the anterior chamber. The lens implant was encapsulated "cocoonlike." Secondary proliferation of corneal endothelial cells covered the fibrous membrane and the chamber angle structures. No inflammatory reaction and only a very slight foreign-body reaction in the area of the footplate of the anterior chamber lens were present. Clinical and histopathological findings indicate that polymethylmethacrylate is sufficiently inert and biocompatible to be tolerated by the surrounding ocular tissues for more than 30 years.

Anterior Chamber↗

PubMed1990

Congenital nonpigmented epithelial iris cyst removed by block-excision.

A 1-month-old white girl developed a rapidly progressing congenital nonpigmented iris cyst covering the pupil and displacing the lens and ciliary body. The cyst was completely removed using a modified block excision (9 x 3.5 mm). The tumor consisted of partially keratinizing cuboidal epithelium with goblet cells, which was covered by proliferating corneal endothelium on the outside. Histopathological, and scanning and transmission electron microscopic findings are described. The postoperative course is unremarkable for 1 year. To our knowledge this case is the first case of a congenital iris cyst successfully treated with block-excision.

Cysts↗

PubMed1990

Autologous nasal mucosa transplantation in severe bilateral conjunctival mucus deficiency syndrome.

From 1984 to 1989, 24 patients with desperate ocular surface wetting problems due to mucus deficiency syndrome with extensive symblephara or lid fusion were treated by autologous free transplants of nasal mucosa from the nasal conchae. This procedure covers the ocular surface not only with nonkeratinizing epithelium but also with goblet cells and produces a mucus layer. This was proven by biopsy in three patients after 1 to 3 years. In all of the patients, conjunctival transplants were not available. Pronounced relief of pain and modest visual improvements are achieved with this procedure, and free autologous nasal mucosal grafts appear to be superior to buccal mucosa in reestablishing the anterior ocular surface. The authors recommend the technique for all patients with massive and otherwise intractable symblephara following lye burns.

Adolescent↗

PubMed1990

[Bacterial pathogen and resistance spectrum of the non-irritated conjunctiva. 7,845 preoperative smears at the ophthalmologic clinic of the Erlangen university].

The type and extent of bacterial colonization of the conjunctiva at the time of an intraocular operation may have a major influence on the risk of post-operative endophthalmitis. Between March 1986 and December 1988 a total of 7845 preoperative conjunctival smears were therefore examined by culture of Erlangen University Eye Hospital, in cooperation with the Department of Clinical Microbiology. Altogether, 1221 (15.6%) of the smears were classified as positive. Surgery on the patients concerned was postponed and gentamicin eye drops were administered for decontamination of their conjunctivae until the smears were negative. From the positive smears 1393 strains were cultured, identified, and submitted to a resistance test. The present paper reports the frequency distribution of the species of bacteria isolated and their resistance behavior, and compares the results with those of other authors. The value of preoperative cultures in the prevention of postoperative endophthalmitis and the importance of resistance tests in the context of topical application of antibiotics are discussed.

Bacteria↗

PubMedDate not supplied

Correlation of microcirculation architecture with ultrasound backscatter parameters of uveal melanoma.

Ultrasound tissue characterization parameters of size and acoustic concentration can be used to sub-classify uveal melanoma and estimate the patient's risk of death. Histologically determined microcirculation patterns have also been found to sub-classify uveal melanoma and predict patient's risk of death. This study examines the spatial relationship between tumor features detected by the two techniques. Three dimensional ultrasound images that depict the size and relative concentration of scattering elements in uveal melanoma within a range of approximately 50-120 microns were compared with PAS (without hematoxylin) stained histological sections graded and localized according to tumor microvascular patterns. Both ultrasound parameter imaging and histopathology were accomplished by workers masked to the other procedure. In three of five patients vascular networks were identified histopathologically. The predominant ultrasound feature seen in the regions of the histologically identified networks were clusters of scatterers in the range of approximately 50-80 microns. In the two cases without a network vascular pattern, lower range scatterers dominated the tumor volume. All the cases could be distinguished by the size and distribution of contiguous spatial clusters of acoustic scatterers. Scatterer size features detected in three dimensional ultrasound parameter images can identify tumor regions containing a specific microvascular pattern. Ultrasound tissue characterization features used to sub-classify uveal melanoma may have a biophysical basis related to patterns of tumor microcirculation.

Blood Vessels↗