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Biomedical subjects

V Rusch

Publications and source records attributed to V Rusch.

43 records · Page 3Linked to original sources
PubMed1984

[Immunostimulation in an animal model using intestinal bacteria preparations].

The treatment of mice with an injection preparation consisting of killed R-tribes of non-pathogenous E. coli caused an increase in microbicidic activities in the animal's blood and effects a significant protection against consecutive infections with Salmonella typhimurium. The enhancement of the animal' resistance capacity appears to be non-specific, and connected with the activity of leucocytes. Oral application of preparations of intestinal bacteria led to increased resistance against consecutive infections with Salmonella typhimurium and Haemophilus influenzae. Three different oral vaccines have been used: Streptococcus faecalis and E. coli, a viable vaccine of non-pathogenous Streptococcus faecalis and a viable vaccine of E. coli. The enhancement of the resistance can be attributed to an induction of the chemotactic efficiency of the animal neutrophilic cells. The chemotactic response of these cells seems to be enhanced. The mode of action of both the other oral vaccines remains obscure.

Adjuvants, Immunologic↗
PubMed1983

Influence of different dietary regimens upon the composition of the human fecal flora.

The composition of the fecal flora in two groups of children in primary school age with (a) normal, ad libitum diet (school-group, 20 children), and (b) lacto-ovo-vegetarian diet (Salem-group, 20 children) was examined. Fecal analysis was concentrated upon the isolation of the main anaerobic and aerobic microorganisms. The pattern of S-, M-, and R-forms of Enterobacteriaceae with special regard to E. coli was investigated additionally. In the school-group counts of Clostridium species, R-, and M- forms of E. coli were significantly higher than in the Salem-group. The numbers of Bifidobacterium, Actinomyces, and Enterobacteriaceae species, as well as S-forms of E. coli were significantly increased in the Salem-group, as compared to the school-children. The data reveal a relationship between the occurrence of different anaerobic species and the SMR-pattern of E. coli, with Clostridium species in particular. The SMR-pattern of E. coli may reflect conditions of intestinal metabolism and mucosal immunity. It may serve as a simple parameter in routine examination of fecal specimen.

Bacteria↗
PubMed1983

Application of S. faecalis and E. coli oral vaccines in humans and animals.

Vaccines of non-pathogenic intestinal bacteria for oral administration have been used in the therapy of chronic and recurrent infections by the German Medical Association for Microbiological Therapy for over three decades. Three different oral bacterial vaccines were used in particular: 1. A sterile autolysate of non-pathogenic S. faecalis and E. coli; 2. a viable non-pathogenic S. faecalis vaccine, and; 3. a viable non-pathogenic E. coli vaccine. Clinical studies indicate the safety and efficacy of these bacterial products, and suggest the stimulation of immune activities and competitive capacities of S. faecalis and E. coli as mode of action. In animal experiments, orally administered intestinal bacterial vaccines enhance the resistance of mice against subsequent challenge with lethal doses of Salmonella typhimurium and Haemophilus influenzae. Mice were allowed access to a viable suspension of either S. faecalis or E. coli for at least 3 weeks. They were then challenged with either of the two unrelated pathogens. Both pre-treatment procedures conferred significant protection of the animals. The mechanism of this protective action appears to involve modification of white blood cell kinetics in the mice. The peritoneal resident cell population in mice is significantly increased by S. faecalis treatment.

Administration, Oral↗
PubMed1980

Crohn's disease in the older patient.

The progress of 141 consecutive patients with Crohn's disease, operated upon by the same surgeons, was examined. Patients were compared by age of onset of the disease. Few patients with Crohn's disease were older than 50 years of age and even less had a diagnosis after this age. Nevertheless, there are certain features that appear to single out these patients. It appears that Crohn's disease in patients older than 50 years in whom the disease was diagnosed before the age of 50 years, mimics that of the younger patients. An operative recurrence is not common and the mortality minimal. Patients in whom the disease is diagnosed after the age of 50 years have a relatively short duration of symptoms, no fistulas and no hydronephorosis; hemorrhage was a more common indication for operation than was intractability. These patients have just as severe a course, if not more so, than the younger patients with a marked operative recurrence and complications requiring reoperation and a significant mortality. Subsequent to all operations, all these older patients still require medical treatment and, yet, are symptomatic.

Adolescent↗