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Biomedical subjects

V S Baĭkova

Publications and source records attributed to V S Baĭkova.

7 recordsLinked to original sources
PubMed1998

[Significance of adjuvant radiotherapy in the surgical treatment of patients with non-small-cell lung cancer].

The study comprised 702 patients radically operated on for non-small cell cancer of the lung: surgery alone--351; radiation + surgery --110; (Eighty-seven patients of the latter group received an intensive course of radiation with a total target dose (TTD) of 20 Gy); surgery + fractionated radiation with TTD 50-55 Gy--195; radiation + surgery + radiation--46. No significant increase in overall or stage-related survival was registered for application of either modality as compared with controls. To establish indications for adjuvant radiotherapy, a prognostic factor study was undertaken using the regression model of Cox. The presence of metastasis in mediastinal nodes (N2) is considered the main indication for combined treatment. In the absence of metastasis in the regional nodes (N0) or in case of metastatic involvement of the nodes of the radix pulmonis (N1), adjuvant radiotherapy was not followed by a significant increase in survival rates even in cases of extensive local primary tumor (T3) and other unfavorable factors. Surgery + radiation or radiation + surgery + radiation for extensive non-small cell disease (T1-3N2M0) led to a significant (p < 0.05) rise in overall and recurrence-free survival rates and reduced the risk of local recurrences as compared with surgery alone.

Carcinoma, Non-Small-Cell Lung↗
PubMed1997

[Current methods in the diagnosis and therapy of lung cancer].

A 45-year experience of diagnosis and treatment of lung cancer is presented. In groups at high risk of cancer, photoroentgenographic screening has proved effective. The use of out-patient complex pulmonologic examination serves to improve identification of central cancer. Early cancers of the lung can be reliably detected in 92.2% of patients with central cancer and in 92.6%-peripheral localizations of tumor. After radical surgery, 5-year survival in cases of stage I tumor was 63.5: stage II-43.5 and stage III-22.9%, mean 5-year survival (irrespective of stage) being 37%. Postoperative radiation was shown to be followed survival over 5 years in cases of non-small cell carcinoma (N2). Early diagnosis and combined therapy are key in raising efficacy of lung cancer treatment.

Humans↗
PubMed1989

[Evaluation of the efficacy of intensive preoperative irradiation of patients with lung cancer].

The study discusses the results of treatment in 118 radically operated lung cancer patients: surgery alone--66 and combined therapy including preoperative irradiation (4 Gy for 5 successive days, total focal dose--20 Gy)--52 cases. Radiation treatment did not significantly affect the patient's general condition, nor did it interfere with surgical procedure, increase operative blood loss or postoperative lethality. However, the postoperative complication rate was higher in the radiotherapy group (51.9 +/- 6.9%) than in the surgery alone group (39.4 +/- 6.0%) mainly due to increased incidence of cardiovascular disorders in patient older than 55 years of age suffering heart pathology. Radiation treatment assured a higher 5-year survival rate (32.0 +/- 9.2% as compared to 14.2 +/- 5.7%) in squamous-cell lung cancer. The beneficial effect of irradiation was most apparent in cases of central squamous-cell lung cancer with intact regional lymph nodes.

Adenocarcinoma↗
PubMed1980

[Pneumoscintigraphy for control over the state of the vascular bed and bronchi in lung cancer patients in the radiation treatment period].

The potentialities of pneumoscintigraphy (its perfusion and inhalation variants) were estimated to assess the state of the broncho-vascular system in 35 patients, subjected to radiotherapy for lung cancer. It was found that nearly all patients with bronchial cancer showed an impairment of the perfusion and ventilation which was dependent on tumor localization and the degree of its local-regional proliferation. Studies on the pulmonary blood flow and ventilation in these patients during radiation treatment have demonstrated in most of them restoration of the involved bronchus drainage function, while in a half of the patients, in whom some regression of the tumor process was revealed roentgenologically, no improvement of the perfusion was noted. Also, it is stated that perfusion scanning is of great importance in estimating the efficacy of radiotherapy for regional metastases.

Adult↗
PubMed1977

[Evaluation of the surgical and combined treatments of lung cancer].

Ninety six patients with lung cancer metastasizing in regional lymph nodes were clinically examined by randomization method. A half of these patients was subjected only to surgical treatment, the other half was given postoperative radiotherapy. The comparison of the results of the combined and solely surgical treatment of lung cancer patients indicated a greater survival in irradiated patients.

Adenocarcinoma↗