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Biomedical subjects

V S Beliaev

Publications and source records attributed to V S Beliaev.

At least 19 recordsLinked to original sources
PubMed1989

[Lipid peroxidation and the status of the antioxidant systems of the blood and liver in isolated and combined action of copper- containing dust and sulfur dioxide].

During the clinical examination of copper smelters the disorders of some body systems were detected. They were assumed to be caused by changes in the ratio of lipid peroxidation and antioxidative body activity. The study of isolated and sulphur dioxide-combined effect of copper dusts on rats revealed that interaction of sulphur dioxide metabolites and metals, contained in dusts, formed a "vicious circle" and reduced protective capacities of antioxidative blood systems and liver, thus giving rise to body accumulation of cytotoxic products of lipid peroxidation.

Air Pollutants↗
PubMedDate not supplied

[Regularities of corneal tissue correlation and their biological significance for regeneration and pre-tumor growth].

Experimental denervation of the central portions of the cornea in rabbits permitted us to hypothesize "autonomism" of corneal tissues, manifesting as soon as corneal tissues loose connection to the nervous system inhibiting cell growth and division. It involved edema, decreased differentiation, loss of correlation between the epithelium and stroma, submerged growth, and eventually even transformation into a sort of tissue culture in the organism. Experiments demonstrated that increased tissue differentiation is paralleled by in-growth of nerve endings. The degree of differentiation and functional intactness of tissues is maintained by the nervous system. If there are no conditions for reinnervation or the injury (irritation) is repeated, the process transforms into pathological: cords of immature tissue penetrate into the depth of the eye from open edges of corneal and scleral wounds, granulation of chronic wounds is abnormal, and pretumor states of tissues develop. Further status of such tissue apparently depends on new vessels, repeating the transformation of epithelial stroma and connective tissue. Increased growth of the epithelium and stromal elements leads to thickening of vascular wall, dilatation of vascular lumen, and to complete obliteration. Repeated irritation resumes the process of tissue transformation with formation of new vessels. Angiogenesis is apparently related to denervation, and each new irritation induces repeated vascular growth. Treatment and prevention are to be aimed at removal of the irritants and improvement of the nervous system function maintaining the maturity of tissues in an organism.

Animals↗
PubMedDate not supplied

[The optimization of a surgical intervention to stabilize progressive myopia].

Results of 236 sclera-fortifying surgeries are followed up for more than 25 years. Progressive myopia stabilized in 95.8% cases after bandaging scleroplasty and in 87.03% cases after chondroplasty. Clinical refraction and posteroanterior axis of the eye did not increase after surgery; visual functions stabilized, and brightness sensitivity threshold was lowered. The technique of operation and clinical course of the postoperative period are described. Based on analysis of the clinical material, the authors propose the optimal approach to scleroplastic operations aimed at stabilization of progressive myopia.

Adolescent↗
PubMedDate not supplied

[Sinusotrabeculectomy with regulated filtration in the treatment of secondary glaucoma].

A new method for surgical treatment of secondary glaucoma (neovascular, postuveal, traumatic, and aphakic) is described. The aims of the new method are as follows: regulation of ophthalmic tone in the postoperative period, pain relief, organ preservation, stabilization of the process, and creation of reliable routes of intraocular fluid discharge with formation of a stable diffuse functional pad. Seven patients (8 eyes) aged 13-70 years were operated on and followed up for up to 6 months. Preliminary results are presented. Positive shifts were observed in all cases.

Adolescent↗
PubMedDate not supplied

[Remote results of high myopia surgical correction by tunnel keratoplasty ].

Remote results evidence high refraction efficiency of tunnel keratoplasty, stable results being observed for up to 15 years. A total of 104 operations (58 patients) were analyzed for a period of observation of more than 10 years. The patients' ages varied from 17 to 52 years, there were 34 women and 24 men. The main advantage of interlamellar refraction meridional keratoplasty is easiness of operation. At present it is the operation of choice for dosed reduction of eye refraction aimed at correction of high myopia and astigmatism. The possibility of correcting residual myopia after keratotomy and repair of refraction abnormalities resultant from perforating keratoplasty is particularly interesting. The possibility of regulating the corrective effect in remote periods by replacing the implants also deserves attention. Hence, low traumatism, high efficiency, and stability of the refraction effect once more confirm our recommendation to use tunnel keratoplasty in clinical practice.

Adolescent↗
PubMedDate not supplied

[Long-term results of surgical prevention and correction of progressive myopia].

In this summing-up paper the authors discuss the results of surgical prevention and correction of progressive myopia carried out at Department of Ophthalmic Diseases of Russian University of Peoples' Friendship during two recent decades. Remote results of bandaging scleroplastic and reduced chondroplastic operations recommend scleroplastic interventions for prevention of myopia progress. Combined scleroplasty and cataract extraction stabilized the elongation of the antero-posterior axis of the eye and essentially improved visual acuity of 18-20 diopters. New variants of interlamellar operations are presented: tunnel-circular and fragmented circular, which are protected by patents of the Russian Federation. These operations are recommended for patients with stable myopia of 8-15 diopters after scleroplasty. Their advantage is low traumatism, absence of deep incisions on the cornea, wide optic center, possibility of regulating the refraction effect by replacing the implants or their complete removal without serious consequences for the cornea.

Female↗
PubMedDate not supplied

[Surgical treatment of certain forms of secondary glaucoma].

The technique of penetrating deep sclerectomy with suprachoroidal explanto-drainage as well as the results of postoperative follow-up, exceeding 2 years, and of the early-described sinustrabeculectomy with regulated filtration are presented in the article. Operations were made on 59 eyes (58 patients aged 13 to 70) with the below forms of secondary glaucomas: new-vascular, postuveal, dystrophic (at retinal detachment), posttraumatic (contusion-type), phakotopic, postoperative (aphakic), and hemolytic. The below goals were set while elaborating the methods: the possibility to regulate postoperatively the intraocular pressure, elimination of the pain syndrome, the organ-preserving effect, stabilization of the clinical cause and shaping-up of reliable drainage paths. The authors registered a positive effect in 87.5% of cases.

Adolescent↗