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Biomedical subjects

V S Efimov

Publications and source records attributed to V S Efimov.

At least 19 recordsLinked to original sources
PubMed1998

A synthetic polycation, a copolymer of 1-vinyl-3-methylimidazole iodide with maleic acid diethyl ester, increases passive ionic permeability in erythrocyte membranes modified by fatty acids.

The effect of the synthetic polycation VMII-DEMA (a potential antiheparin agent) on the ion transport through erythrocyte membranes was studied using ion-selective electrodes. We found that the passive ionic permeability of erythrocyte membranes in the presence of VMII-DEMA noticeably increased after the pretreatment of erythrocytes with long-chain fatty acids. When used separately, neither polycation nor fatty acids changed the membrane permeability at the same concentrations. The efficiency of the combined action of the polycation and fatty acids correlated with the length of the fatty acid (C9-C18) and the number of double bonds in it. The fatty acids C12:0, C13:0 and C18:2 were the most efficient. We suggest that in pathologies accompanied with deteriorations in lipid metabolism, polycations used for the correction of blood coagulation may damage the erythrocyte membrane.

Cations↗
PubMed1996

A new approach for creating double-stranded DNA biosensors.

The principle of 'sandwich'-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was approximately 10-(14) M.

Animals↗
PubMed1995

Blood coagulation changes in pregnant women at risk of developing preeclampsia.

OBJECTIVES: A group of 50 pregnant patients were studied with regard to the time of onset of hypercoagulation, its character and mechanisms of initiation in the development of preeclampsia. METHODS: The blood coagulation characteristics, antithrombin (AT)-III and endogenous heparin levels were studied. All of the patients were designated at risk of developing preeclampsia at the time of registration at the antenatal clinic. RESULTS: Retrospective evaluation shows that endogenous heparin levels and AT-III activity decreased by nearly 50% within 15 days of the development of preeclampsia and were particularly low 1-7 days before the onset of clinical signs of preeclampsia. CONCLUSIONS: These findings indicate that abnormalities in AT activity are a marker of hypercoagulation and begin more than 2 weeks before the development of clinical signs of preeclampsia.

Adult↗
PubMed1993

Investigation of long-term hypocoagulability in rats after intratracheal administration of unfractionated heparin.

The comparative study of intratracheal and intravenous administration of heparin on blood coagulation and mast cell population was carried out in experiments in rats. Unlike the intravenous injection of heparin which induces fast short-time inactivation of all clotting factors, single intratracheal injection of heparin inactivated the intrinsic pathway of thrombin generation. Long-term hypocoagulability after intratracheal administration of heparin was related to the accumulation of heparin in mast cell.

Animals↗
PubMed1992

[Mechanism of prolonged hypocoagulation appearing after intratracheal administration of heparin].

The comparative study of intratracheal and intravenous effect of administration of heparin on blood clotting and mast cell population condition was carried out in experiments. Unlike intravenous bolus injection of heparin, which induced fast short-time inactivation of all enzyme clotting factors, a single intratracheal injection inactivated "internal" rout of thrombin production. It was shown, that long-term hypocoagulability effect and inhibition of factors of blood coagulation after intratracheal administration of heparin correlated with accumulation of heparin in mast cell.

Animals↗
PubMed1991

[Means of lowering the perinatal mortality in pregnant women with diabetes mellitus].

The paper gives some current approaches to the management of pregnant women with diabetes mellitus, in terms of perinatal medicine. These are based on a comprehensive detailed clinical examination of 104 patients, which involves the hormonal fetoplacental complex function, hypophyseo-thyroidal system, hemocoagulation system by using ultrasonic tools (fetal biometry and echocardiography, Doppler echometric studies of the fetoplacental blood flow in the umbilical vein, umbilical artery, and fetal aorta). A differential approach was proposed to the management of pregnancy and delivery of patients with diabetes mellitus, which allows perinatal mortality to be reduced.

Female↗
PubMed1989

[Rheologic properties of the blood and the system of hemostasis in patients with circulatory encephalopathy treated by hemosorption].

In patients with atherosclerotic encephalopathy (AE) the major indices of blood rheology, hemostasis and its cells' functional state were under investigation. Different patterns of blood rheology changes were detected with increased counts of pathological red blood cells and hypercoagulability. These disorders correlated with the rate of major neurological signs and syndromes, and with the disease stage as well. A multilevel positive effect of hemosorption was shown in different pathogenic links of AE related to disorders in lipid metabolism, blood rheology, shape and functional activity of erythrocytes, shifts in the homeostatic systems. This suggested the use of hemosorption as a tool in prevention of ischemic stroke.

Adult↗