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Biomedical subjects

V S Kazantsev

Publications and source records attributed to V S Kazantsev.

At least 19 recordsLinked to original sources
PubMed2000

[Specific dermatoglyphic traits of patients with occupational allergic bronchitis].

Dermatoglyphic traits proved to be closely associated with chronic mechanic bronchitis (CMB). With the most informative traits identified, it is possible to estimate the individual predisposition to this occupational disorder and thereby to increase the efficiency of preliminary and follow-up medical examinations. Comparison with data on dermatoglyphic traits predisposed to various types of pneumoconiosis supported the hypothesis on a single mechanical lung disease or "general dust lung disease".

Allergens↗
PubMed2000

[Multifactorial analysis of risk factors for lung cancer in the city of Tula].

A multifactorial epidemiologic study of high incidence of lung cancer was conducted in the city of Tula. Mathematical methods of pattern recognition were used. The influence of 20 factors of risk was evaluated. The leading ones were tobacco smoking, occupational exposure to carcinogenic substances and precancerous lesions in the lungs. The influence of industrial pollution on cancer morbidity was assessed as moderate. Mathematical estimates for effectiveness of correction of "controllable" risk factors were given.

Adult↗
PubMed1994

An approach to detecting delayed effects of radioactive contamination on industrial-urban-area dwellers.

Detecting changes in humans that result from radioactive contamination of the area of residence many years after an incident (i.e., when the radiation has substantially decayed) presents a difficult epidemiological problem. Problems of this kind are even more complicated ina areas where the population is continually exposed to other harmful man-made factors. The city of Kamensk-Uralsky (Sverdlovsk region, Russia) is a good case in point. In 1957, part of Kamensk-Uralsky was contaminated as the result of an accident at the Kyshtym nuclear plant. In addition, the population of the contaminated area is being exposed to atmospheric emissions from several industrial enterprises. Two comparable groups of residents were formed: one in the contaminated are and another in a control area within the same city characterized by similar levels of chemical pollution but substantially lower radioactive contamination. The groups were composed of only those people who had been living in these areas continually since time of the accident and who were under 15 years of age at the time of the accident. The groups were matched by sex, age, and socio-occupational characteristics. For each subject, data were gathered on more than 50 parameters including hematological, immunological, and biochemical indices of the health status. All these data were obtained from blood tests taken in the fall of 1992. Data processing was carried out with the help of a computerized mathematical pattern recognition methodology, which ensured reliable discrimination between the generalized health status in the areas under study. We found that the health status of inhabitants of the area more contaminated with radioactive fallouts was adversely affected by radiation.

Adult↗
PubMed1993

[Genetic markers of susceptibility to myocardial infarct].

The study with the two genetic markers--HLA antigens and the pattern of dermatoglyphics--provides strong evidence for the fact that there is a genetic predisposition to coronary heart disease. The dermatoglyphic pattern has been found to be a more reliable marker of predisposition to this disease than HLA antigens. The decisive rules derived from the study may be used in the assessment of a genetic risk for this cardiovascular abnormality.

Dermatoglyphics↗
PubMed1993

[Markers of genetic susceptibility to malignant neoplasms].

Fifty-eight lung cancer and 71 gastric cancer patients were matched with corresponding healthy controls versus such risk factors as age, sex, nationality, tobacco smoking, alcohol drinking and occupation. HLA-antigens and dermatoglyphic patterns were used as genetic markers. Multivariate analysis employed mathematical procedures of pattern recognition. The results using HLA-antigen technique were not satisfactory. On the contrary, lung cancer studies based on 16 most informative dermatoglyphic parameters yielded reliable decision rules which proved 100% effective in control group and 83.3% effective in cancer patients. In gastric cancer studies, the best results (87.5% of correctly recognized patterns in both groups) were obtained, when 20 parameters were used. Correlations between pattern types and cancer of the lung and stomach have been identified. It is suggested that complete dermatoglyphic picture may be used as a marker of genetic predisposition to oncological disease.

Adult↗
PubMed1991

[Computerized consult system in gastroenterology].

Expert computer systems proved their efficacy in medicine, being a useful tool of solving complicated diagnostic and therapeutic tasks. One of these is being developed in the field of gastroenterology by the therapists of the Sverdlovsk Medical Institute and mathematicians of the Mathematical and Mechanical Institute of the Ural Department of the USSR Academy of Sciences. The system operates in the language REXX and PASCAL using ES 1045 computer and is able to teach subinterns skills of gastroenterological examinations, to assess professional skills of the gastroenterologist, to consult the internist in complicated diagnostic situations.

Decision Making, Computer-Assisted↗
PubMed1989

[Relation between genetic and non-genetic factors of individual susceptibility to silicosis].

The study was carried out at a number of industrial enterprises at risk of silicosis by means of the methodological approach based on the mathematical theory of image discrimination. It was shown that under the given conditions of dust exposure higher or lower probability of the development of silicosis and silicotuberculosis in an individual depended on the whole set of environment and endogenic factors, involving genetic predisposition to the disease as one of the leading factors. The impact of the above factors being similar irrespective of the type of the enterprise, their comparative contribution could be different. Thus reliable prediction of high probability of the disease development could be provided by means of the method of multifactorial analysis only as applied to specific conditions of the given enterprise. In spite of low prevalence of the genotype of silicosis- and silicotuberculosis-associated resistance, under the exposure to quartz dust, high probability of the disease development was predicted only in a number of cases if other individual symptoms were taken into account along the genotype. Therefore it became possible to identify the most susceptible persons at the stage of medical vocational selection.

Bronchitis↗
PubMedDate not supplied

[Evaluation of the efficiency of the activities of therapeutic and preventive services].

Two methodological approaches to evaluation of the efficiency of medical activities, based on estimation of an integral index and expert evaluations, were investigated in 14 hospitals of Chelyabinsk. Both approaches are based on 12 parameters characterizing the work of outpatient clinics and hospitals and are routinely used in medical statistics. Comparison of classifications of treatment-and-prophylaxis institutions of Chelyabinsk in 1994-1998 obtained with the use of both methods showed that the method based on estimation of the integral parameter is more objective. Its another advantage is the possibility to modify the number of signs used and thus to evaluate the efficiency of the entire medical institution and its structural units (outpatient center, hospital). The efficiency rating can serve as the basis for adopting appropriate managing decisions.

Health Care Reform↗
PubMedDate not supplied

[Evaluation of radon effects on lung cancer development].

In order to evaluate the effect of indoor exposure to radon and thoron on the development of lung cancer in the population of two towns of Sverdlovsk Region, epidemiologic studies were conducted using a multifactarial method of analysis. Both towns, Pervouralsk and Karpinsk, are located within the geological area with the gamma-radiation exposure dose ranging from 5 to 12 mu r/hr, and are characterized by an increased cancer incidence rate--323.1 and 364.6 cases per 100,000 of population, respectively. The mean values of the voluminous indoor activity (VA) of radon in Pervouralsk and Karpinsk were 23 and 75 Bq/m3 (with maximal indices of radon VA being 395 and 739 Bq/m3), equivalent equilibrium concentrations (EEC) of residential radon and thoron were 0.6 and 2.5 Bq/m3 (maximal indices of EEC of thoron being 5 and 13 Bq/m3), respectively. The results of multifactorial analysis of 22 different lung cancer risk factors carried out using the pattern recognition method proved that the contribution of thoron and radon in the development of lung cancer in the population of Pervouralsk and Karpinsk was not significant--0.5 and 0.6%, respectively. The calculations performed in a monofactorial model of risk evaluation BEIR VI gave different results--11-16% and 35-52% for the towns of Pervouralsk and Karpinsk, respectively. The discussion of the results provides arguments for the reliability and adequacy of the application of multifactorial method of radiation risk evaluation as compared to the traditionally applied monofactorial method.

Air Pollution, Indoor↗
PubMedDate not supplied

[Dermatoglyphics and cancerous diseases].

The dermatoglyphic analysis of finger and palm prints was conducted in oncologic patients living in the same town and in corresponding with respect to the number control groups of inhabitants of the same town that were matched to each patient by the most relevant risk factors. The study was based on 61 dermatoglyphic characters. Using computer pattern recognition programs sufficiently informative subcomplexes of these characters were formed. They permitted to discriminate between ill and control persons.

Breast Neoplasms↗
PubMedDate not supplied

[Assessment of radioactive irradiation of Kamensk-Uralski inhabitants and its impact on their descendants' health].

The radioactive radiation of the inhabitants of the town of Kamensk-Uralsky, Sverdlovsk Region, was studied for its impact on the health of their descendants. The radiation of parents was found to be a risk factor for increasing the high incidence of frequent respiratory diseases of their children. The dietary deficiency of vitamins in children and other factors are also causes of frequent respiratory diseases.

Adult↗