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Biomedical subjects

V S Lobzin

Publications and source records attributed to V S Lobzin.

At least 19 recordsLinked to original sources
PubMed1996

[The effect of interleukin-2 on interferon production by human lymphocytes and the importance of this test in autoimmune diseases].

Interleukin-2 (IL-2) was demonstrated to induce interferon (IFN) production in the cultured lymphocytes from healthy donors and myasthenia gravis (MG) patients. Moreover, IL-2 enhanced lymphocytic IFN production in patients and healthy individuals in response to phytohemagglutinin and concanavalin A. However, in MG patients, IFN production in response to IL-2 alone or in combination with mitogens is several times lower than that in healthy donors. This lowered IFN production in MG patients is accompanied by much higher rates of lymphocytic proliferation and by considerably enhanced spontaneous lymphocytic production of C-reactive protein as compared with healthy individuals. This test may be of great value in establishing the diagnosis of an autoimmune disease, in defining its severity and in evaluating the efficiency of therapy.

Autoimmune Diseases↗
PubMed1994

[Development of occupational vertebral radiculopathies and tunnel syndromes].

The study proved occupational and everyday strain of muscles and ligaments to be risk factor for ischemic and compression neuropathy. The pathologic changes appeared to involve not only compression points, but also the sites distant from the primary area and ultimately the whole axon. Therefore, spinal roots and nerves could be affected by complicated and multiple ischemic and compression radiculopathies demonstrating typical clinical signs.

Construction Materials↗
PubMed1993

[The differentiation of the pathogenetic variants of nerve trunk lesions].

There are two major variants of nerve trunk disease progression: demyelinating and axonal-axial. The authors have developed a significant and rapid diagnostic procedure to differentiate the type of nerve trunk affection based on simultaneous assessment of two parameters (immunological and electroneuromyographic) carrying out correlations between them. The immunological investigation included measurement of the serum autoantibodies to galactocerebrosides titer.

Autoantibodies↗
PubMed1993

[Asthenic-autonomic disorders in the decompensation phase of residual organic brain conditions].

The paper provides characteristics of asthenic and vegetative-vascular defects in decompensation of residual organic cerebral insufficiency. The defects were examined vegetologically with the help of photoplethysmography, thermovisiography, the test of the vegetative, psychological, exercise performance. Cutaneous-galvanic reflex, attention, memory, asthenia severity were also evaluated. The data obtained by the authors are important for making differential diagnosis of cerebrogenic with psychogenic asthenia in neurosis which allows differential therapy of asthenia symptoms depending on the etiological factor.

Adolescent↗
PubMed1992

[The physiotherapy of patients with lumbar spinal osteochondrosis in the early period after surgical treatment].

Altogether 130 patients with associated lumbar spinal osteochondrosis and the radicular syndrome were placed under observation after operation in the form of laminectomy and removal of hernia of intervertebral discs. On days 2-3 after the operation the patients were given different physiotherapy modalities: sinusoidal modulated currents (SMC), electroacupuncture by sinusoidal modulated currents (EAP) and acupuncture (AP). The control group patients were administered conventional drug therapy. According to the data on the disease clinical picture and the rate of impulse conduction in the motor nerve, the treatment efficacy was higher in patients on physiotherapy as compared to the controls. In patients with the predominance of the painful syndrome, EAP and AP were most effective; EAP was most effective in associated pains and motor losses; SMC appeared effective in isolated motor disorders. The drugs slightly reduced the pains but did not recover motor function.

Adult↗
PubMed1992

[Autonomic vascular disorders in neuropathies and the methods for their pathogenetic therapy].

Investigations were made to examine vegetovascular disorders in patients with inherited and acquired neuropathies (regional vegetative innervation, peripheral circulation and the thermal status of the limbs). Comprehensive, pathogenetically based treatment methods were developed. Using clinico-neurological, thermography, rheovasography and electrothermography research methods the following alterations were revealed in the autonomic areas of innervation of affected nerves: the signs of vegetovascular irritation; the signs of vegetovascular depression; a phenomenon of thermovision "amputation". Bearing in mind the diagnostic data, the patients were given differentiated pathogenetic therapy including physiotherapy and vegetotropic drugs.

Adolescent↗
PubMed1992

[The use of bemitil in patients with progressive muscular dystrophies].

Bemithyl treatment was carried out in 22 patients with neuromuscular diseases (progressive myodystrophy). The actoprotector bemithyl inhibited in these patients the processes of lipid peroxidation, activation of neoglucogenesis favours improvement of interorganic exchange of metabolites. Bemithyl is recommended in patients with progressive myodystrophy along with drugs normalizing the protein, energy and electrolyte metabolism.

Adolescent↗
PubMed1991

[Clinico-immunological research on patients with different forms of amyotrophic lateral sclerosis].

Changes in the immunological status of patients with lateral amyotrophic sclerosis (LAS) point to the involvement of the autoimmune component into the disease pathogenesis. At the same time there is a correlation between the intensity of immunological disorders and the age, disease pattern and the rate of the pathological process generalization. The lowering of immunological functions is noted to decline with age, possibly leading to the rise of the LAS incidence in older persons.

Adult↗
PubMed1991

[Pathogenetic therapy of trigeminal neuralgia].

The authors describe a clinical case of severe neuralgia of the third branch of the trigeminal nerve, in whose etiology and pathogenesis a role was played by allergic vasomotor rhinosinusopathy, general allergization of the body, and recurrent herpetic infection. The patient was treated by carbamazepine, tranquilizers, prednisolone, antihistamine and diuretic agents, calcium drugs, bonaphthon, vitamin B1, essentiale, acupuncture, local hydrocortisone phonophoresis and laser therapy. Such treatment made it possible to effectively remove the neuralgic painful syndrome. The given case demonstrates that the painful syndrome is due to several pathological systems having different pathophysiological and neurochemical organization, demanding a differentiated individual approach and providing evidence for the necessity of carrying out the etiological and pathogenetic therapy.

Adult↗
PubMed1991

[Mechanisms of the therapeutic effect of bemitil in neuromuscular diseases].

Studies into the mechanism of the therapeutic action of bemitil were carried out in 21 patients with neuromuscular diseases. Measurements of lipid peroxidation and permeability of the erythrocytic membranes demonstrated the drug to influence carbohydrate and lipid metabolism, lipid peroxidation, and permeability of the cellular membranes. It is recommended that bemitil be used for the treatment of neuromuscular diseases.

Adolescent↗
PubMed1991

[Status of the carpal canal in compressive neuropathy of the median nerve (computerized-tomographic examination)].

Computer-aided tomography of the carpal canal was performed in 30 patients syndromes of the carpal canal and in 20 healthy persons. Topographoanatomic interrelations of carpal canal structures were specified, degenerative and dystrophic alterations of the carpal bones, proliferation of the connective tissue, displacement of carpal structures and of the median nerve itself were revealed.

Adult↗
PubMed1991

[Laser correlation spectroscopy of the blood serum in assessing the efficacy of hemosorption with myasthenia patients].

In 30 patients with myasthenia the authors studied the dynamic of changes of subfraction content of the blood serum using the method of laser correlation spectroscopy. Significant changes of the blood serum homeostasis have been revealed in the process of hemosorption. The obtained results make it possible to develop objective criteria for indications to hemosorption as well as for the assessment of the efficacy of therapy.

Adolescent↗
PubMed1990

[Clinico-physiological and histochemical criteria in the evaluation of the effectiveness of physiotherapy of myotonia].

To improve the peripheral circulation, to exert an antihypoxic action on muscle tissue, to stimulate oxidation processes, to relieve the physiological phase of myorelaxation, and to diminish the intensity of myotonic reactions, 34 patients with myotonia were treated by combined administration of benzohexonium and sodium hydroxybutyrate amplipulse-phoresis. All the patients underwent a comprehensive examination using classical electrodiagnosis, electromyography, electroneuromyography, thermography and histochemical tests. As a result of the treatment, 23 patients (67.7%) demonstrated the positive dynamics of the clinical and electrophysiological parameters.

Adolescent↗
PubMed1990

[Indicators of lipid peroxidation and erythrocyte membrane permeability in patients with myasthenia gravis].

Twenty-five patients suffering from myasthenia with no thymectomy were examined for lipid peroxidation (LPO) and erythrocytic membrane permeability. A study was also made of spontaneous and induced LPO, the level of diene conjugates and permeability of the erythrocytic membranes in mixtures of isotonic urea and sodium chloride solutions of varying volumetric concentrations. LPO activation which was coupled with an increase of erythrocytic membrane permeability was revealed. The data obtained point to the impairment of membrane apparatus function in patients with myasthenia and allow recommending the use of the membrane-stabilizing therapy.

Adolescent↗
PubMed1990

[Myasthenic crises].

The authors analyze the course of myasthenia complicated by the development of the myasthenic crisis, provide the data obtained over the recent 5 years by the clinic of nervous diseases of the Leningrad Institute of Advanced Medical Training, review the causes leading to the development of the myasthenic crisis, its clinical manifestations, discuss the problems of the diagnosis and treatment.

Adult↗