Stereocontrolled synthesis of unsaturated halohydrins from unsaturated epoxides.
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Alkenes↗
Biomedical subjects
V S Martín
Publications and source records attributed to V S Martín.
Double cationic propargylation: from linear to polycyclic ethers.
[reaction: see text]. The trapping of cations generated from Co2(CO)6-bispropargylic alcohols provided diethers in good yield. The procedure is also valid when two vicinal acetylenes are present. The methodology can be applied to the synthesis of symmetrical or unsymmetrical linear or cyclic propargylic ethers. The use of substrates with a stereochemically defined secondary nucleophilic alcohol provided cyclic ethers with a high degree of stereocontrol.
Journal Article↗
General stereoselective synthesis of chemically differentiated alpha-diamino acids: synthesis of 2,6-diaminopimelic and 2,7-diaminosuberic acids.
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Amino Acids, Diamino↗
Beta-hydroxy-gamma-lactones as chiral building blocks for the enantioselective synthesis of marine natural products.
The enantioselective synthesis of trans-(+)-laurediol, (2S,3S,5R)-5-[(1R)-1-hydroxy-9-decenyl]-2-pentyltetrahydro-3-furanol, and (2S,3S,5S)-5-[(1S)-1-hydroxy-9-decenyl]-2-pentyltetrahydro-3-furanol are described. In addition, a formal synthesis of trans-(-)-kumausyne is also developed. All the synthetic procedures have in common the use of enantiomerically enriched beta-hydroxy-gamma-lactones, easily available by Sharpless asymmetric dihydroxylation (AD) from the suitable beta,gamma-unsaturated ester. The use of Katsuki-Sharpless asymmetric epoxidation (AE) as an additional enantioselective reaction provides cyclic compounds of high enantiomeric purity.
Biological Products↗