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Biomedical subjects

V S Moiseev

Publications and source records attributed to V S Moiseev.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Cardiomyopathies, nonspecific myocarditis and alcoholic heart lesions (data from the clinical study of 100 patients)].

Echocardiography and immunological tests were applied to follow and examine 100 patients with grave non-coronarogenic myocardial lesions. Of these, 14 patients had hypertrophic cardiomyopathy (CMP) of the obstructive type, 21 hypertrophic non-obstructive CMP (symmetrical, apical, septal), 15 congestive CMP, 34 nonspecific myocarditis, and 16 alcoholic lesion of the heart. Congestive CMP, nonspecific myocarditis, and alcoholic lesion of the heart were characterized by some symptoms in common: dilatation of heart chambers, heart insufficiency, arrhythmias, thromboembolism. Myocarditis can be diagnosed according to the common and laboratory signs of inflammation, appearance of inflammatory pathology in other organs, changes in the immunological characteristics (reduction in the leukocyte migration index under the effect of cardiomyocyte membrane antigen), therapteutic effect of steroidal therapy. Alcoholic lesion of the heart can be recognized on case history specification (including the questioning of the subjects having relations with the patient), and identification of other symptoms of alcoholism. The possibility of making differential diagnosis of the diseases under consideration has been demonstrated.

Adult↗
PubMed1980

[Cardiovascular aspects of systemic lupus erythematosus pathology].

The authors had 213 patients under observation with systemic lupus erythematosus. Changes in the heart were revealed in 171 patients, all had affection of the myocardium: myocarditis was found in 66 and myocardial dystrophy in 122. Appraisal of leucocyte migration inhibition with the myocardial antigen (in 23 patients) and detection of antibodies against the myocardium by immunofluorescence (in 33) suggest that disorders in cellular immunity play an important part in the development of lupus myocardial affection. Involvement of the heart in patients with systemic lupus erythematosus was partly associated with renal hypertension, which was conducive, first and foremost, to the development of myocardial hypertrophy and could be attended with increased cardiac ejection and peripheral resistance. A decrease in the cardiac output with a gradual growth in the activity of systemic lupus erythematosus was noted. Steroid myocardial affection was found in 1/4 of patients, which sometimes occurred with cardiac insufficiency and signs of inflammation. Besides mitral valve sclerosis (7%), mitral stenosis was revealed in 3 patients and aortic insufficiency in one. Echocardiography helped to make an early diagnosis of hypertrophy of the heart and pericardial effusion in patients with systemic lupus erythematosus.

Antibodies↗
PubMed1975

[Activity of the dehydrogenases of the myocardium and lymphocytes in experimental hypoxia].

The activity of succinatedehydrogenase, mitochondrial alpha-glycerophosphatedehydrogenase and NADH2-diaphorase was studied cytochemically and histochemically in the myocardium and lymphocytes of rats and mice after the effect of hypoxia in a hyperbaric chamber. A short-duration effect of hypoxia and step-wise adaptation during a month was shown to result in a growing activity of the enzymes both in the lymphocytes and in the myocardium. Hypoxia during a month and readaptation during the same period caused a monotonous decrease of the activity of dehydrogenases. The conducted analysis permitted to reveal a distinct correlation between the activity of dehydrogenases in the lymphocytes and in the myocardium. The authors emphasize the similarity of the changes in the activity of the enzymes in the lymphocytes and in the myocardium.

Animals↗
PubMed1975

[Cardiovascular pathology in dermatomyositis].

Among 110 patients with dermatomyositis cardiovascular pathology was found in 77, and only in 37 of them it was attributable to the underlying pathology. In all of these patients myocardial lesions were found, that manifested themselves most frequently by non-specific ECG changes. Cardiac insufficiency and arrhythmias were revealed less frequently, mainly during exacerbations of the pathological process. Only in one patient endocarditis was diagnosed, and in two others elements of chronic cor pulmonale due to pneumonitis. In 18 patients signs of moderate myocardial dystrophy developed after a long-term therapy with corticosteroid hormones. A study of the central haemodynamics in 20 patients with dermatomyositis revealed a tendency towards a hyperkinetic state of the circulation in those patients who had the most sereve muscle syndrome. Angioscopy of the bulbar conjunctiva revealed the changes that persisted even during the remission period, achieved by means of active steroid therapy.

Adolescent↗