PubMed Health⌕ Search

Biomedical subjects

V S Moroshkin

Publications and source records attributed to V S Moroshkin.

8 recordsLinked to original sources
PubMed2002

[High-resolution ECG in assessment of myocardial functional state in patients with ischemic heart disease and resultant cardiac dilatation].

High resolution signal-averaged ECG (SAECG), echocardiography and 24-hour Holter ECG monitoring were used in the study of 30 patients (mean age 56-/+2 years) with coronary heart disease and stable class II-IV angina (group 1) and 66 patients (mean age 45-/+1 years) with dilated cardiomyopathy of ischemic origin (group II). SAECG was used for detection of late ventricular potentials and calculation of time-voltage and velocity parameters of P-waves. Disturbances of myocardial de- and repolarization indicative of pronounced hemodynamic left atrial overload associated with elevated left ventricular end diastolic pressure were revealed. These disturbances were more pronounced in patients of group II. Late ventricular potentials and arrhythmias were more frequent in patients with more severe cardiac failure. Sensitivity of SAECG for detection of arrhythmogenic substrate in the myocardium was 70 and 90% in groups I and II, respectively. Positive predictive power of ventricular late potentials for occurrence of ventricular arrhythmias in these groups was 86 and 91%, respectively.

Action Potentials↗
PubMed1998

[The connection between late ventricular potentials and ventricular arrhythmias in hypertension patients with different forms of myocardial hypertrophy].

AIM: To estimate the incidence of late ventricular potentials (LVP) and their implication in cardiac arrhythmia. MATERIALS AND METHODS: 53 patients with blood hypertension stage II (mean age 50 +/- 1 years) having symmetric (n = 23) and asymmetric (n = 15) left ventricular hypertrophy as well as 15 patients free of hypertrophy underwent conventional 12-lead ECG, Holter monitoring, echocardiography and late potentials (LP) recording using signal-averaged high resolution ECG. RESULTS: LP occurred more often in asymmetric myocardial hypertrophy than in symmetric one. There was no strong correlation between LP and ventricular arrhythmias except patients with symmetric myocardial hypertrophy. CONCLUSION: In patients with hypertension stage II late potentials seem to arise due to increased hypertrophic myocardium depolarization time, myocardial fibrosis and local intramural blockades.

Adolescent↗
PubMed1993

[The relationship between the pathogenetic mechanisms of effort stenocardia and the pharmacodynamics of anti-anginal agents].

A single administration of nitroglycerin, corinfar, anapriline was studied for effects on exercise tolerance in 33 patients with exercise-induced angina with varying adrenergic vasoconstriction during exercise estimated by responses to pratsiol. The effect was found to be related to the degree of functional vasoconstriction. It is concluded that there is a pathogenetic heterogeneity of angina on effort in which in 57% of patients having high coronary reserve, adrenergic vasoconstriction along with organic changes in of great value in the genesis of myocardial ischemia during exercise. In 33% patients with low coronary reserve, the major role is played by organic changes in the coronary bed and vasoconstrictive responses are unassociated with adrenergic exposure. Only in 12% of patients the functional component of coronary vasoconstriction is lacking.

Adult↗
PubMed1992

[Study of the role of adrenergic vasoconstriction in the development of dynamic coronary obstruction in patients with stress-induced stenocardia].

The aim of the present investigation was to evaluate sympathetic vasoconstrictor influence and to define its role in the formation of coronary occlusion in patients with effort angina. The investigation covered 22 patients with Functional Class II-III stable effort angina. To detect vasoconstrictor responses on exercise and to identify their adrenergic component, pair bicycle tests were performed before and after administration of nitroglycerin and pratsiol. Repeated bicycle tests were conducted twice a day: at 10-11 a.m. and at 3-4 p.m. to study spontaneous exercise tolerance variations confirming the presence of dynamic coronary occlusion. The examinations indicated that in 18 patients the exercise resulted in functional major artery narrowing, aggravating the organic stenosis. Activation of smooth muscle alpha-adrenoreceptors is of a definite significance in the genesis of dynamic coronary occlusion in 50% of all the examinees.

Adrenergic Fibers↗
PubMed1985

[Myocardial electrical activity and hemodynamic indices in the early stage of the rehabilitation of myocardial infarct patients].

Available indirect methods were employed to examine 52 patients with a history of myocardial infarction and 18 normal subjects by the end of the early rehabilitation period. Hemodynamic overload of the left atrium was revealed. The main hemodynamic parameters and processes marking contractile and electrical myocardial functions did not return to normal. The symptoms of left ventricle failure persisted thus requiring treatment continuation.

Adult↗