Biomedical subjects
Publications and source records attributed to V S Petersen.
The Mennen plate has been used for osteosynthesis of 5 femoral fractures, 4 of which were at the tip of a prosthesis stem. Union was achieved in 2 fractures, and loss of fixation of the plate in three.
A human-mouse hybridoma has been produced by fusion of Hashimoto thyroid lymphocytes with the mouse myeloma line X63-Ag8.653. The cloned hybridoma secreted 2.5 micrograms per 10(6) cells per day of an IgG kappa thyroid peroxidase (TPO) autoantibody (2G4) with high affinity (2.5 x 10(9) molar-1) and specificity for human TPO. 2G4 did not react with lactoperoxidase, horseradish peroxidase or human myeloperoxidase or with porcine TPO or with human thyroglobulin. Plastic tubes coated with 2G4 bound about 50% of 125I-labelled human TPO added and the binding was inhibited by IgGs prepared from 18/18 TPO autoantibody-positive sera. This indicated that all 18 sera contained autoantibodies which recognised the same (or closely related) epitope as 2G4. Plastic tubes coated with IgGs from different TPO autoantibody-positive patient sera also bound 125I-labelled TPO but inhibition by 2G4 in this system was not complete. This suggested that the sera contained at least 2 types of TPO autoantibodies, with only one type of autoantibody reactive with the same epitope as 2G4.
Total hip replacement was performed in 27 patients aged 80 years and older. In the early postoperative period, medical complications occurred in 13 patients and arthroplasty-related complications in 5 patients. At the time of the follow-up, after an average of 31 months, there was one case of acetabular cup loosening, which was revised. Twenty of 22 patients were free from pain at rest, and the social function of the patients had remained almost unchanged.
The supracondylar fracture of the femur is a serious complication after total knee arthroplasty. We report our experience in the management of 16 patients with this complication and suggest that the main line of treatment should be conservative. Open reduction and plate fixation is precarious. In displaced fractures, however, the Rush pin technique was useful.
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The wrist motion in 31 healthy probands was measured by four observers with a simple goniometer under standardized conditions. The INTRA-observer variation was calculated to 5 to 8 degrees and the INTER-observer variation to 6 to 10 degrees. No difference between experienced and non-experienced observers was found. The difference between the right and the left wrist was negligible, indicating that the opposite wrist can be used as reference when evaluating restrictions in motion.
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In the county of Frederiksborg, Denmark, all distal radius fractures in inhabitants over 20 years of age were recorded throughout 1981; the population at risk was a quarter million, and fractures occurred in 394 women and 99 men. The age-specific incidence confirmed the rise in osteoporotic fractures over the past 20 years demonstrated recently in Malmö and Oslo.
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