Can endothelial cells accumulate lipids?
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Biomedical subjects
Publications and source records attributed to V S Rabinovich.
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Data on cellular-molecular aspects of the development of immune inflammation in vascular wall under atherogenesis are considered. Own results and literature data on the investigation of mechanism of adhesion of agrannulated leucocytes on endothelium, role of macrophages and T-cells in modification of apoprotein B-containing lipoproteins, production and secretion of proinflammatory cytokines and acute phage proteins by "intima" cells are considered. A conception evaluating atherogenesis as a local immune inflammation in the arterial wall is considered.
Data from literature are given on the role of "acute phase" proteins in inflammation and their connection with lipoproteins. Intensive production of acute phase proteins is shown to take place in modelling of experimental atherosclerosis. The hypothesis is proposed that allows to consider the acute phase reaction of the liver as a very important condition of modified lipoproteins formation acquiring autoantigenic properties.