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Biomedical subjects

V S Rotenberg

Publications and source records attributed to V S Rotenberg.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

The revised monoamine hypothesis: mechanism of antidepressant treatment in the context of behavior.

The temporal restoration of brain monoamines in the synaptic cleft due to MAO inhibition or by blocking catecholamine reuptake is only the first step on the way to recovery from depression. The second and crucial step represents the feedback system, which can provide the continuous restoration of brain monoamines in the context of free search behavior. This feedback system on the one hand helps to overcome depression and on the other hand causes the hyposensitivity of the postsynaptic catecholamine (CA) receptors, due to the increased activity of the brain CA system. According to the search activity concept, REM sleep in the healthy subject, being a part of the same feedback system, restores brain monoamines. The mechanism of REM sleep deprivation in the treatment of depression is discussed in the context of this feedback system.

Animals↗
PubMedDate not supplied

Neurotic and psychosomatic disorders. Interdependence in terms of the search activity concept.

There are no correlations between MMPI Hysteria (Hs) and Depression (D) scales in psychosomatic patients in contrast to other patients with somatic disturbances, neurotic disturbances, and in healthy subjects. The roles of depression and hypochondria in the dynamics of psychosomatic disturbances are discussed according to the search activity concept. It is suggested that hypochondriacal complaints are prognostically favorable in comparison with anxiety-depression complaints.

Adaptation, Psychological↗
PubMedDate not supplied

Search activity in the context of psychosomatic disturbances, of brain monoamines and REM sleep function.

The author discusses a number of controversial aspects of the search activity concept. This concept, based on an analysis of data cited by other researchers and the results of the author's own investigation, performed together with V. V. Arshavsky, postulates that search activity raises the body's resistance to stress and experimentally induced pathology whereas renunciation of search forms a nonspecific predisposition to somatic disturbances (e.g., psychosomatic disease). REM sleep is regarded as a specific form of search activity aimed at compensating for the state of renunciation of search in walking. In this paper the author argues that 1) renunciation of search can be accompanied either by anxiety or by depression, 2) REM sleep deprivation on a "small platform" raises the requirement in REM sleep by producing renunciation of search, 3) during search activity brain catecholamine synthesis is stimulated by catabolism whereas a state of renunciation of search upsets this feedback system. The actuation of the brain mechanisms of search in REM sleep necessitates a certain brain catecholamine level. If the brain catecholamine level is very high during waking behavior due to intensive search activity, the REM sleep requirement is low, REM sleep becoming reduced. After a moderate drop in the brain catecholamine level at the initial stage of renunciation of search the requirement in REM sleep rises and this phase grows longer. But at the late stage of renunciation of search the brain catecholamine level drops extremely, REM sleep shrinking in spite of the great appropriate requirement, and 4) the functional insufficiency of REM sleep invites various forms of pathology.

Animals↗
PubMedDate not supplied

GSR as reflection of decision-making under conditions of delay.

A total of 15 healthy individuals of both sexes, aged from 18 to 30 years, were studied. The subjects were presented a series of three audio signals in each of two conditions. Under condition A the subject made a first immediately after the third signal if all the three sounds were identical; under condition B, a fist was made if at least one sound was different from the other two. The GSR was particularly pronounced when the decision to make or not to make a fist was made under conditions where action was delayed.

Adolescent↗