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V S Sakalo

Publications and source records attributed to V S Sakalo.

At least 19 recordsLinked to original sources
PubMed1996

Ukrain treatment in a patient with non-seminomatous germ-cell tumour of testis (case report).

A 31 year old patient with non-seminomatous germ-cell tumour of the testis was treated with Ukrain following operation and gamma-radiotherapy. 20 mg Ukrain ampoules were injected i.v. twice weekly with a total dose of 200 mg for each of three courses of treatment. Within the period of 24 months observation no recurrence or metastases were found. The results testify that Ukrain in complex treatment of patients with non-seminomatous germ-cell tumours of the testis can contribute to optimisation of immune status which improves the prognoses and results of treatment.

Adult↗
PubMed1994

Radionuclide diagnosis of regional metastases in patients with testicular tumours.

We have studied 181 patients with germ-cell tumours of the testis. The first group comprised 80 persons without evidence of metastasizing into retroperitoneal lymph nodes; the second group included 101 patients with germinal testicular tumours metastasizing into regional lymph nodes. Eighty patients were subjected to transperitoneal lymphadenectomy which allowed comparison of the results of lymphoscintigraphy (negative radionuclide diagnosis with colloid agents labelled with gold and technetium positive radionuclide diagnosis with 99mTc-pertechnetate) with the findings of histologic examination. We demonstrated high significance of lymphoscintigraphic methods: sensitivity 83%, specificity 90.9%, significance 86.2%. It was found that information obtained with lymphoscintigraphy can serve as clinical guidelines in determining the site, size and spread of metastasizing, which is very important in choosing fields of irradiation. Lymphoscintigraphy in testicular tumours enables more accurate staging and radicality of lymphadenectomy at different time intervals after surgery.

Adolescent↗
PubMed1988

[Activity of natural killer cells in patients with testicular germ cell tumors].

The level of activity in natural killer cells (mononuclears) of peripheral blood relative to 51C-labelled K-562 cells is found to be significantly lower in patients with germinative testicle tumours than in donors. At the same time neither mononuclears of the peripheral blood nor those isolated from the tumour tissue practically lyse tumour tissue cells. The higher activity of natural killer cells relative to K-562 cells corresponds to the higher immunocellular infiltration of the tissue from nonseminomatous tumours.

Adolescent↗
PubMed1988

[Treatment of patients with stage I-II non-seminoma germ-cell tumors of the testis].

Stage I--II disease was identified in 71 out of 219 patients with nonseminomatous germ cell tumors of the testis. After orchifuniculectomy, polychemotherapy was given to 30 patients while the rest underwent transperitoneal lymphadenectomy. Long-term survival in the polychemotherapy group was 83.3%, in the lymphadenectomy one--95.1%. After excision of the retroperitoneal lymph nodes, the patients' follow-up should include regular assays of such tumor markers as alpha-fetoprotein and chorionic gonadotropin as well as X-ray examination of the chest for at least the first 24 months. Polychemotherapy should not be administered unless tumor dissemination or an increase in tumor marker levels are detected.

Adolescent↗
PubMed1988

[Effects of chemotherapy on regional metastases of non-seminomatous tumors of the testis].

A comparative evaluation of histologic patterns of non-seminomatous testicular tumors was carried out in 2 groups of patients: those receiving platinum derivative-based preoperative chemotherapy (31) and chemotherapy-free cases (36). Preoperative cytostatic treatment potentiated cell differentiation in retroperitoneal metastases in some patients, the latter effect being considered prognostically favorable.

Adult↗
PubMed1984

[Clinical course and morphological characteristics of different types of seminoma].

A comparative analysis of morphological peculiarities and clinical course of seminoma makes the case for distinguishing three types of the tumor. Prognosis in cases of typical seminoma depends on the level of differentiation of tumor cell elements and stage of tumor. Alkylating drugs and radiotherapy should be a method of choice in treatment of patients with typical seminoma. High orchofuniculectomy may be sufficient at the initial stages of spermatocytic seminoma due to its favorable clinical course determined by a high level of specific differentiation of tumor cells. Electron microscopic analysis of anaplastic seminoma showed cells with signs of differentiation towards trophoblast (chorionepithelioma elements) and embryonal entoderm (yolk sac tumor) characterized by a relatively higher malignancy. These data account for the tendency of anaplastic seminoma to rapidly disseminate and suggest application of adjuvant chemotherapy and lymphadenectomy.

Adolescent↗
PubMed1983

[Germ cell tumors of the testis following orchiopexy].

Out of 335 patients with testicular neoplasms, cryptorchidism was concomitant in 84 cases (25%). 28 patients underwent orchiopexy at the age of 5-52 years. Tumor was detected, on the average, 14,4 years after the operation. Orchiopexy contributes to carcinogenesis in the undescended testicle. The rate of incidence of non-seminomatous tumor is relatively higher in patients after orchiopexy than in untreated cases of cryptorchidism. Patients with undescended testicle should be referred to a group at high risk and be followed up.

Adolescent↗
PubMedDate not supplied

[The use of lyophilized blood serum for determining the 3-HAA antigen in patients with precancerous diseases and cancer of the bladder].

3-OAK antigen was determined by immunodiffusion in agar by means of immune sera containing antibodies against 3-OAK. In patients with cancer of the urinary bladder the percentage of detecting 3-OAK-Ag in the native serum was 76.9 while in lyophilized it was 41.9. In patients with pretumorous diseases (leukoplakia, chronic cystitis, papillomas) their values were 64.1 and 56.1 respectively. It is concluded that lyophilized blood serum may be used in the clinical practice for immunological and serological examinations.

3-Hydroxyanthranilic Acid↗
PubMedDate not supplied

[The diagnostic and prognostic value of tumor markers in nonseminomatous stage-III to -IV testicular tumors].

The effect of combined treatment was studied in 97 patients with nonseminomatous testicular tumors with regional and distant metastases with regard to the blood serum levels of alpha-fetoprotein and chorionic gonadotropin. The disease stage was found closely correlating with the efficacy of the treatment and the level of tumor markers. Complete remission was observed in 84.2 per cent (16 out of 19) patients with normal marker levels and in 26.8 per cent (11 out of 41) of those in whom both markers levels were raised (p less than 0.05). A continuous follow-up revealed that increased marker levels were the evidence of tumor relapse or metastases in clinically silent patients.

Adolescent↗