Death in springtime.
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Adaptation, Psychological↗
Biomedical subjects
V S Sloan
Publications and source records attributed to V S Sloan.
Reducing sleepiness on the roads and on the wards.
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Humans↗
Aspirin in in-flight emergencies.
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Aerospace Medicine↗
A potential mechanism of cyclosporine-associated bone pain: comment on the radiologic vignette by Stone et al.
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Bone and Bones↗
Transgenic mouse models of experimental autoimmune encephalomyelitis.
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Animals↗
Mediation by HLA-DM of dissociation of peptides from HLA-DR.
Human leukocyte antigen (HLA)-DM is an unconventional major histocompatibility complex (MHC) class II heterodimer that is important for B-cell-mediated antigen processing and presentation to MHC class II-restricted T cells. HLA-DM is encoded by two genes, DMA and DMB, which map to the MHC class II region, and shares some homology with MHC class I and class II proteins. Here we define the biochemical role of HLA-DM. Recombinant soluble HLA-DM heterodimers have been purified from culture supernatants of insect cell transformants. At pH 5.0, they induce the dissociation of a subset of peptides bound to HLA-DR, including a nested set of class-II-associated invariant chain peptides (CLIP). This process liberates HLA-DR and leads to the enhanced binding of exogenous peptides.
Amino Acid Sequence↗
Sexual behavior in Peace Corps volunteers.
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Acquired Immunodeficiency Syndrome↗
MHC and infectious diseases.
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Communicable Diseases↗
Classification of reactive arthritides.
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Arthritis↗