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V S Vaidhyanathan

Publications and source records attributed to V S Vaidhyanathan.

18 recordsLinked to original sources
PubMed1975

Hydrodynamic analog model for pharmacokinetics I: model and its usefulness.

A novel hydrodynamic model for drug distribution, when the drug is administered intravenously in physiological systems, is presented. In addition to obtaining results of familiar multicompartment models, the theory presents fresh insights into pharmacokinetic problems. A detailed procedure is included for evaluating drug-physiological system parameters such as the elimination rate constant, volumes of distribution, and permeability properties from the experimental time course of concentration of the central compartment.

Diffusion↗
PubMed1975

Hydrodynamic analog model for pharmacokinetics II: critical examination of model and its contribution to pharmacokinetics.

A comparison of the conventional pharmacokinetic models and the previously proposed hydrodynamic diffusion analog model is presented. A significant result that an n-compartment system can exhibit at best (n - 1) extremum times in the concentration-time plot of the central compartment under appropriate values of physiological parameters is presented. The observation of kinks experimentally in certain physiological-drug systems is thus shown to be amenable to explanation.

Dicumarol↗