Biomedical subjects
V S Zeligman
Publications and source records attributed to V S Zeligman.
[The value of determining antibodies to DNA in patients with purulent diseases of the lungs].
Anti-DNA antibody titers are elevated in the patients with purulent diseases of the lungs and antibodies to nDNA appear that are undetectable in normal subjects. These data correlate with the inflammatory process activity in the lungs, with the diameter of the decayed cavity, disease duration, and efficacy of therapy. Dynamic titration of antibodies to DNA (particularly nDNA) over the course of the disease appears to be an important prognostic test reflecting the stability of autoimmune impairments and the efficacy of the therapeutic scheme used in the treatment of patients with purulent diseases of the lungs.
[The significance of body reactivity indices for the diagnosis and treatment of acute pneumonia].
The assessment of lymphocytic functional activity and immunological reactivity in 114 cases of acute pneumonia provided additional information on the disease severity, potential complications, effectiveness of the treatment conducted, completeness of recovery. The study of immunological reactivity in acute pneumonia is beneficial in poor clinico-roentgenological manifestations. Combined treatment with levamisole promoted improvement of immunological reactivity and reduced the duration of disability.
[Variants of the course of acute dermatomyositis].
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[Difficulties in the diagnosis of primary cancer of the liver].
Case records have been analyzed for 92 patients with primary cancer of the liver. The discrepancies between the clinical and postmortem diagnosis reached 31%. It appeared that the exact diagnosis depended on valid evaluation of the disease history, clinical signs and findings at special examinations rather than on the number of investigations. Associated liver cirrhosis recorded in 24% of cases put another obstacle for a precise vital diagnosis. The study has furnished evidence for a judgment on the incidence of hepatic cancer, concomitant cirrhosis, possible etiologic factors, the state of clinical diagnosis and causes of death.
[Levamisole and splenin in combined therapy of patients with bronchiectasis].
Follow-up of 114 patients with bronchiectasis has demonstrated that immunomodulation agents levamisole and splenin included in combined treatment augment their therapeutic effect and normalize the immune status of patients. This is manifested by normalization of the amount and functional activity to T-lymphocytes, the content of IgG, IgM and IgA and the autoimmune shifts. A favourable effect was encountered significantly more often than that in patient who were treated by the traditional methods without the use of the immunomodulation agents and in those who were given only levamisole and splenin together with anti-bacterial and hygienic therapy.
[Differential diagnosis in fever of unknown origin].
A study of 156 patients admitted to the clinic with the diagnosis of "fever of unclear genesis" indicates that the most frequent cause of this condition are pathological processes in the abdominal and retroperitoneal space, renal diseases, patients with bacterial endocarditis and connective tissue diseases. Detailed clinical analysis makes it possible mostly to establish a correct diagnosis at early terms of the disease.
[Correction of hepatic morphofunctional disorders in mechanical jaundice of a nontumorous nature].
The authors examined 68 patients with cholelithiasis complicated by mechanical jaundice. The clinical course of the disease, functional and morphological changes of the liver were elucidated. Different hepatic functions were involved: the protein-forming, pigmentary, enzymatic, etc. Morphological changes of the liver revealed severe dystrophic changes in the liver parenchyma including necrosis of some parts the liver. The employed complex of therapeutic measures allowed to carry out operative interventions in more favourable conditions that reduced the number of postoperative complications.
[The treatment of peptic ulcer].
Problems are discussed on the differential pathogenetic treatment of patients with duodenal ulcer. Variants are singled out of the course of ulcer disease depending on the prevalence of clinical symptoms. The characteristic features of these symptoms are described and the most rational and individualized therapeutic complexes for each of these clinical variants are evaluated.
[Clinical aspects of Osler-Rendu disease].
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[Case of antemortem diagnosis of dissecting aneurysm of the aorta].
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[Characteristics of Conn's syndrome].
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[Effect of the passive orthostatic position on kidney function in healthy persons and in patients with cardiac insufficiency].
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[Improved method of the mathematical treatment of dye dilution curves for the quantitative determination of general hemodynamics].
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[Rhythm of the atrio-ventricular junction with the varying rate of orthograde conduction].
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[Change in human kidney activity in passive orthostatism and head-down tilting].
Changes in the natriuretic and water excretory renal functions of healthy people during tilt table tests--with the head-end lifted upwards at an angle of 45 degrees and lowered at an angle of -15 degrees--were investigated. The renal excretion of sodium, water and osmotically active substances decreased drastically during the first 20 min of the headdown tilting and continued to fall down during the next 20 min. These changes were induced by an increase in the rate of tubular reabsorption of filtrate, sodium and osmotically free water rather than by a significant decrease of glomerular filtration rate. After tilting to the horizontal position circulation and glomerular filtration parameters rapidly returned to the normal. However, sodium clearance, diuresis and osmolar clearance remained decreased till the end of the experiment due to the further increase in the tubular reabsorption rate of sodium and water. During head-down tilting an increase in natriuresis, diuresis and osmolar clearance was seen which was related to an increase in the glomerular filtration rate and a decrease in the tubular reabsorption rate of filtrate, sodium and osmotically free water.