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Biomedical subjects

V Sabata

Publications and source records attributed to V Sabata.

At least 19 recordsLinked to original sources

[Follow-up of the development of children up to the age of 8-12 years after prenatal glucose infusion].

Children whose mothers were given prenatally glucose infusions as therapy of foetal hypotrophy were examined at the age of 8-12 years. A group of 24 of these children were compared with a group of 29 controls born as hypotrophic without prenatal glucose infusions. All children were born after the 37th week of gestation. Complications in the neonatal period were more frequent in the control group; no relationship of the subsequent development and postnatal hypoglycaemia was found, a less favourable development was recorded in one third of the children with a history of polycythaemia. Between the two groups of children no differences in morbidity were found, however, neurological abnormalities and other complications were less frequent in children who had the infusion. The assumption that the development of children born hypotrophic can be favourably influenced by prenatal glucose infusions seems justified according to long-term results.

Child

Glucose tolerance tests in women with small-for-date fetuses and newborns.

Peroral glucose tolerance tests were performed in women with small-for-date fetuses and in controls with healthy fetuses in the 38th week of pregnancy, 2 days and 6 weeks after delivery. 2 h after the load of 50 g of glucose, the blood glucose level remained significantly higher in pregnant women with small-for-date fetuses. The other parameters followed did not exhibit any difference from the control group. Since this deviation disappeared very rapidly after delivery it may be supposed that it is caused by hormonal and other influences of the atypical conceptus and not by a primary derangement of maternal metabolism or by a disparate responsiveness of the maternal organism to pregnancy.

Blood Glucose

The effect of fructose infusions in the course of labor upon parturient and fetus.

Fructose infusions were administered to parturients with healthy term fetuses at a speed of 1 g/min for 106 on the average. The results confirm that fructose has the expected properties. The blood glucose and FFA levels show that a substantial part of the infused fructose is indeed stored and that only a small portion is used to cover immediate energy needs. This positive result is predominant by a considerable degree of acidosis arising in the parturient in spite of the fact that fructose was infused at a slower rate than in the majority of papers published so far. Since the fructose infusions were intended for premature fetuses, which already have an increased tendency toward acidosis, the results confirm the unsuitability of such a treatment.

Blood Glucose

The effect of prenatal fructose infusions upon metabolic condition of the newborn.

Changes of total blood sugars, glucose, fructose, lactate, pyruvate, acid-base balance and free fatty acids were followed in 15 healthy newborns whose mothers received fructose infusions during labour. The results were compared with 20 control newborns and with 10 newborns after prenatal glucose infusions. The levels of total blood sugars during 24 h after infusions remained higher after fructose than in 2 other groups. The values of lactate and pyruvate increased, but the lactate/pyruvate ratio remained unchanged. The free fatty acids were lower than in the control group. Results show that fructose is not a suitable source of energy for the human fetus even under normal conditions.

Acid-Base Equilibrium