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Biomedical subjects

V Sadony

Publications and source records attributed to V Sadony.

At least 37 records · Page 2Linked to original sources
PubMed1979

Management of extensive lesions of the lower trachea using emergency cardiopulmonary bypass.

Rapid cardiopulmonary deterioration in patients with extensive lesions of the lower trachea presents a serious challenge in the emergency care. Conventional methods may prove inadequate to achieve airway control and to stablilize the critical condition. Severe airway obstruction and/or massive air leakage are the main causes of failure. An aggressive operative approach is mandatory. Institution of emergency cardiopulmonary bypass for resuscitative purposes and definitive surgical repair of those life-threatening uncommon tracheal lesions seems essential to us. Two cases, managed according to this concept, are presented.

Adult↗
PubMed1978

Demonstration in human atrial preparations of alpha-adrenoceptors mediating positive inotropic effects.

In isolated, electrically driven right auricular strips of the human heart the inotropic effect of phenylephrine was studied. 1. First, the influence of the driving rate on the tension developed (i.e., the frequency-force relationship) was determined by stimulation of the preparations at 0.1, 0.5, 1, 2 and 3 HZ. The force of contraction was lowest at a stimulation rate of 0.1 HZ (36.9 g/g dry weight). The maximally developed force of contraction observed at frequencies of 0.5, 1 and 2 HZ amounted to about 200 g/g dry weight. The values did not significantly differ from each other. 2. The negative log of the EC50 (-log EC50) for the positive inotropic effect of phenylephrine determined at a frequency of 0.5 and 1.0 HZ amounted to 5.28 +/- 0.08 and 5.34 +/- 0.11, respectively. The alpha-adrenolytic drug phentolamine (3 x 10(-6) M) diminished significantly the -log EC50 to 5.01 +/- 0.04 and 4.89 +/- 0.10, respectively. 3. At a frequency of 1 HZ a shift of the concentration-response curve to the right was observed after treatment with the beta-adrenolytic drug pindolol (3 x 10(-8) M); the -log EC50 of phenylephrine decreased significantly to 4.08 +/- 0.07. 4. From these results it is concluded that alpha-adrenoceptors are present in human atria; they mediate positive inotropic effects and are stimulated by phenylephrine.

Heart↗
PubMed1975

Oxygen demand and collateral vessels of the heart. Factors influencing the severity of myocardial ischaemic injury after experimental coronary artery occlusion.

Epicardial electrocardiographic maps were used to assess the effect of heart rate, myocardial contractility, and oxygen need on the severity of myocardial ischaemic injury after acute coronary artery occlusion in dogs. The experimental data indicate statistically significant dependence of the severity of ischaemia on heart rate, contractility, and oxygen need of the heart. These dependences are highly influenced by the spontaneous collateral vessels of the heart.

Animals↗