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Biomedical subjects

V Sahadevan

Publications and source records attributed to V Sahadevan.

5 recordsLinked to original sources
PubMed1978

Prostate carcinoma: immunostaging and adjuvant immunotherapy with BCG.

Thirty-three patients with histologic diagnosis of adenocarcinoma of the prostate were entered into separate protocols: 1) immunostaging, and 2) BCG adjuvant immunotherapy. Immunostaging is a new method of assessing patients immunologically prior to and after immunotherapy. Thirty of these patients were immunostaged with the use of humoral and cellular immune parameters. A positive correlation was noted between the patient's immunostage and the clinical stage of his cancer. The 33 patients with a histologic diagnosis of adenocarcinoma of the prostate were entered into an ongoing protocol of adjuvant BCG immunotherapy in addition to conventional therapy (19 patients received BCG and 14 served as controls). The patients receiving BCG had a longer mean survival time; minimal morbidity and no mortality resulted from this therapy.

Adenocarcinoma↗
PubMed1975

Estrogen and estrogen receptors of breast cancer.

Human breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen-binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment. This would greatly improve therapeutic planning for patients with breast cancer. Tumor tissue from 52 patients was investigated for content of both cytosol estrogen and estrogen receptor. In addition, the total tumor estrogen was also determined in 14 of these tumors. The results of this investigation show two distinct groups: one group containing both estrogen receptor and estrogen and a second group with no receptor but with measurable amount of estrogen. Tumors with estrogen receptors have higher tissue levels of estrogen than tumors without specific estrogen receptor. Even in the absence of estrogen recptor, however, most tumor tissue examined contained a measurable amount of estrogen.

Breast Neoplasms↗