PubMed Health⌕ Search

Biomedical subjects

V Sandor

Publications and source records attributed to V Sandor.

31 records · Page 2Linked to original sources
PubMed1985

Experimental anti-ulcer activity of Veronica officinalis L. extracts.

In indomethacin-induced ulcers in albino rats, the anti-ulcerogenic effects of some extracts prepared from Veronica officinalis L. were investigated. The extracts had a significant anti-ulcerogenic activity. In ulcer healing experiments performed in rats by administering reserpine, the extracts were found to enhance the regeneration of the gastric mucosa. These results seem to confirm the popular observations according to which the decoction from Veronica officinalis L. possessed useful properties in the treatment of gastric ulcers.

Animals↗
PubMed1981

Effects of alpha-methylnoradrenaline and alpha-methyldopamine in reserpine-induced ulcers in rats.

alpha-Methyldopamine and alpha-methylnoradrenaline administered intraperitoneally afforded significant protection in reserpine-induced ulcers in rats. The optimal doses were 2 and 4 mg/kg. Lower and higher doses were less effective. alpha-Methyldopamine and alpha-methyl-noradrenaline probably act by reestablishing the normal adrenergic tone which is diminished in reserpine-induced ulcers.

Animals↗
PubMed1980

Effects of intravenous infusion of CaCl2 on the fibrillation thresholds in rabbits.

A study on the atrial and ventricular fibrillation thresholds performed in urethane anaesthetized rabbits showed that no significant change occurred until blood pressure was reduced to 40% of the initial value. Bilateral cervical vagotomy and the administration of propantheline did not affect these changes. (DL) propranolol (0.2 mg/kg i.v.) "unmasked" a tendency of CaCl2 to elevate the fibrillation threshold; it also increased the lethal calcium level.

Animals↗
PubMed1977

Analysis of the mechanism of the protective activity of some sympathomimetic amines in experimental ulcers.

Apomorphine administered in reserpine-induced as well as in restraint ulcers in rats, failed to afford protection. Pimozide, moperone, trifluperidol and chlorpromazine fail to influence the development of the experimental ulcers. Pimozide and moperone although antagonizing the behavioral changes of amphetamine, maintained its antiulcer activity. Amitryptiline, cocaine and morphine had a protective activity. L-Dopa afforded a significant protection which was abolished if this compound was administered together with FLA-63, a specific dopamine-beta-hydroxilase inhibitor. These results were explained by admitting that not dopamine, but noradrenaline was responsible for the antiulcer activity. alpha-Methyl-dopa produced a significant protection in both experimental models.

Amitriptyline↗
PubMed1977

Influence of some sympathomimetic amines on the experimental gastric ulcers in rats.

In reserpine-induced ulcers in rats, the centrally acting sympathomimetic ámines (amphetamine, mephentermine and ephedrine) produced a significant protection. Only amphetamine had a beneficial effect in restraint ulcers. Tyramine, a preponderant peripherally acting sympathominetic amine, was inefficient in both experimental models. It is suggested that the protective activity is due to the influence of these amines on the adrenergic structures, mainly at central level.

Amphetamine↗