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Biomedical subjects

V Scheiber

Publications and source records attributed to V Scheiber.

At least 37 records · Page 2Linked to original sources
PubMed1981

[The social infrastructure of patients with urinary calculi (author's transl)].

The social infrastructure was investigated in 379 patients with urinary stones. The rates of 50% for employees and 32% for old-age pensioners were surprisingly high. 16% of the patients were employed in jobs with hard manual labour. Only 9% of the patients went in for regular physical activity in their leisure. A significant increase in urinary excretion of calcium and uric acid (p - 0.01) and inorganic phosphate (p less than 0.001) was seen in connexion with increase in net income. On the other hand, urinary pH was lowest in the highest income group (p = 0.01). According to these findings an increased net income combined with a lack of physical exercise seems to enhance the risk of stone formation.

Adolescent↗
PubMed1981

[Lactate acidosis in the cerebrospinal fluid as a prognostic parameter of malacic cerebral insult (author's transl)].

The concentrations of lactate and pyruvate were determined in 111 CSF and blood samples. The CSF and blood chemistry of 43 patients with a lateralized ischaemic cerebral insult was compared with that of a control group of 18 patients. The first tests were carried out within 24 to 48 hours and 50 follow-up determinations were undertaken in the cerebral insult group. The patients were classified according to their level of consciousness (lucid-somnolent-soporous-comatose). Covariance analysis revealed a distinct relation between the CSF chemistry and the level of consciousness of the insult patients; accordingly, a continuous increase in the lactate level from 1.54 mmol/l to 3.48 mmol/l and in the pyruvate level from 0.11 mmol/l to 0.21 mmol/l was noted. Spearman's correlation analysis also pointed to a statistically significant correlation between decreasing levels of consciousness and the CSF lactate/pyruvate quotient. The increase in the CSF/blood quotient of lactate from 1.17 to 2.14, corresponding to the decrease in the level of consciousness, also indicates that during the early stages of the disease, cerebral tissue hypoxia is reflected in the CSF rather than in the blood. Further subdivision of the groups according to whether the patients survived or died, showed that the critical maximum concentrations from the prognostic point of view are 2.74 +/- 0.19 mmol/l in the case of CSF lactate, 0.186 +/- 0.017 in the case of CSF pyruvate and 1.92 +/- 0.65 for the CSF/blood quotient of lactate. None of the patients with a CSF lactate level of 3.1 mmol/l or more survived the ischaemic cerebral insult. Thus, the above-mentioned parameters are to be regarded as important indicators of the threat to the patient's life.

Acid-Base Equilibrium↗
PubMed1981

Nutritional risk factors in urinary stone disease.

The relationships between eating and drinking habits, and serum as well as 24-hour urinary concentrations of calcium, inorganic phosphate uric acid and urinary pH were studied in 379 patient in whom stones form. The 24-hour urinary calcium excretion was found to be increased in patients who preferably eat animal proteins and farinaceous foods (p less than 0.1). Regarding drinking habits, urinary calcium and inorganic phosphate excretion was found to increase significantly as a function of alcohol ingestion (p less than 0.01 and p less than 0.001, respectively). Similarly, an increased alcohol intake was found to be associated with higher serum uric acid concentrations (p less than 0.01). A significant increase in urinary pH was confined to patients preferably eating vegetables (p less than 0.005). The results of our study suggest alcohol consumption to be a potentiating factor for the risk of stone formation.

Adolescent↗
PubMed1978

[Determining the average posteruptive age of teeth from the results of cross-sectional studies (author's transl)].

If results of cross-sectional studies must be used as a basis for setting up models of development of caries in permanent teeth, then the average rather than individual posteruptive age of teeth has to be resorted to. Data available for this purpose had been obtained from a total of 54,000 children living in two G.D.R. cities, namely, Plauen and Karl-Marx-Stadt, as well as from two surveys made in 1959 and 1971, respectively. Calculation of the average posteruptive age of teeth assumes good knowledge of the distribution of dates of eruption in a population. Of the three types of distribution considered, namely, normal, lognormal, and log-logistic distribution, the log-logistic model proved to be superior to others because of better adaptation to the data available. The method of calculating the posteruptive age of teeth is described and illustrated by use of a number of examples. Since one of the two surveys (namely that which was made in Karl-Marx-Stadt in 1971) was made after twelve years' drinking water fluoridation, it was possible to study the effect of fluoridation upon the eruptive behavior of permanent teeth. The results of this study confirmed those obtained during previous investigations.

Adolescent↗
PubMed1978

Analysis of a certain type of 2 x 3 tables, exemplified by biopsy findings in a controlled clinical trial.

A procedure is described for the evaluation of 2 X 3 Tables, in which the two rows correspond to the two treatments to be compared and the three columns are ordered classifications ("improved", "unchanged", "deteriorated"). The method is illustrated by an example taken from the recent literature: liver biopsy data from a controlled clinical trial of silymarin in the treatment of chronic hepatitis.

Biopsy↗
PubMed1976

Lipid composition of the rat kidney.

The lipid fractions free fatty acids, triglycerides, cholesterol, cholesterol esters and phospholipids of rat kidney cortex, outer and inner medulla were analyzed by thin-layer chromatography. The concentrations of 23 individual fatty acids in the lipid fractions of each zone were determined by gas chromatography; 14 of them were evaluated by an analysis of variance. For most of the lipid fractions a corticomedullary concentration gradient was found, the highest concentrations occurring in the cortex. The lipid classes primarily determined the pattern of individual fatty acid concentrations. A significant concentration difference between the three zones only existed for 4 of 14 fatty acids. Long chain fatty acids were found in a higher concentration in the phospholipids of cortex and outer medulla (about 95%) in comparison to the inner medulla (65%).

Animals↗
PubMed1976

Distribution of caries among tooth types in fluoride and non-fluoride areas.

A method is described for estimating the preferential caries protective action of fluoride on certain morphological types of permanent teeth. The results of an analysis by this method, applied to data for 1164 Austrian school-children aged 6--14 years, are reported. There was no indication that fluoride would exert its caries inhibitory effect selectively on certain types of teeth. Tentative explanations are put forward for the only inconsistency within the general results observed in 11--14-year-old children having a total of 3 carious teeth.

Adolescent↗
PubMed1976

[Investigation of the frequency of heterozygotes for galactose-1-phosphate-uridyl-transferase-deficiency(galactosemia) in the Vienna area. Comparison with the frequency of homozygotes found by newborn screening (author's transl)].

By routine newborn screening for galactose blood level elevations a great difference in the frequency of Galactosemia by transferase deficiency was observed between Eastern- and Western-Austria. This made enzymatic heterozygousity determinations desirable. At the same time it should be examined whether the frequency of homozygotes found by screening correlates with the frequency derived from the heterozygousity frequency. In a first step the region of Vienna was studied. 377 unselected blood samples were examined following BEUTLER-BALUDA's method. As technical control samples of 9 homozygotes and 12 heterozygotes as found by screening were examined but not included in the frequency study. Arranged following age groups a slight but significant decrease of enzym activity with increasing age could be confirmed (23,89 versus 21,99 U/g Hb). This, increasing the overlapping between normals and heterozygotes of different ages possibly should be kept in mind in individual heterzygousity determinations. The enzymatically determined frequency of heterozygotes was found to be twice as high as the frequency calculated from the frequency of biochemically detected but enzymatically proven homozygotes (1:53 versus 1:99). A comparison of the heterozygousity frequencies found in literature with the results of the most efficient (technically most reliable) screening programs shows that this discrepancy is great and general. Bases on heterozygousity frequencies the frequency of homozygotes found by screening programs seems to be at least 50% too low. Analysis of theoretical possibilities for loss of homozygotes by screening programs makes this explanation highly improbable. It seems more probable that the enzymatically determined heterozygotes frequency is too high by including still undefined allels or allel combinations which result in about half normal activity but not in disturbances resembling classical Galactosemia.

Age Factors↗