Biomedical subjects

V Scornavacche

Publications and source records attributed to V Scornavacche.

3 recordsLinked to original sources

PubMed1987

Mutagenicity studies on thymomodulin.

Thymomodulin (Leucotrofina), an orally administrable thymic derivative endowed with interesting immunomodulating and myelomodulating properties, was tested for mutagenicity by means of the following in vitro and in vivo tests: mutagenesis on S. typhimurium with and without metabolic activation system (S-9), gene conversion on S. cerevisiae D 7 with and without metabolic activation, urinary assay in the mouse with and without metabolic activation, urinary assay in the mouse with S. cerevisiae D 7, host mediated assay in the mouse with S. cerevisiae and DNA repair test with and without metabolic activation. On the basis of the results obtained thymomodulin proved to be free of mutagenic activity.

Animals↗

PubMed1986

A phase II study of mitoxantrone in advanced breast cancer.

A phase II study with mitoxantrone has been carried out in 30 metastatic breast cancer patients. Of 26 evaluable patients 7 (26.9%) experienced a partial response; 7 (26.9%) patients had stable disease and 12 (46.1%) had progression. Major toxicity observed was: nausea and vomiting in 52% of patients, moderate hair loss in 53% of patients and leukopenia in 53%.

Adult↗

PubMedDate not supplied

Comparison of nimesulide and flurbiprofen in the treatment of non-infectious acute inflammation of the upper respiratory tract.

Sixty patients were enrolled in a controlled randomized single-blind study to compare the efficacy and tolerability of 200 mg/day nimesulide and 300 mg/day flurbiprofen given for 7 days, in the treatment of non-infectious acute inflammation of the upper respiratory tract. Patients were diagnosed as follows: pharyngitis, 20 (33.4%) cases; laryngitis 11 (18.3%) cases; tonsillitis, eight (13.3%) cases; and mixed forms, 21 (35.0%) cases. Both drugs showed the same efficacy in reducing mucosal congestion, local redness, fever and sore throat. Nimesulide treatment gave rise to fewer and less severe side-effects than flurbiprofen treatment.

Adult↗