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Biomedical subjects

V Sedlak-Vadoc

Publications and source records attributed to V Sedlak-Vadoc.

7 recordsLinked to original sources
PubMed1993

[The effect of angiotensin I converting enzyme inhibitors on renal function indicators in hypertensive patients].

The paper reviews the results of a preliminary study on hemodynamic and functional kidney indices in patients with hypertension with different etiopathogenesis. The investigation was carried out in 36 patients; 30 cases with no renal artery stenosis (RAS) and 6 cases with different stages of RAS. The investigation was conducted both in basal conditions and after the peroral administration of captopril (Zorcaptil à 25 mg, 1h before the examination). Kidney hemodynamics and its function were investigated by the dynamic kidney scintigraphy with the deconvolution analysis of the renogram and by the determination of the total and separate clearances 99Tcm-MAG3 and/or 99Tcm-DTPA. The obtained results lead to the conclusion that the sensitivity of the applied methodology enables differentiation of hypertensions in whose etiopathogenesis the renin-angiotensin-aldosterone system (RAAS) does not play the key role. Further investigations are needed for valid conclusions to be made.

Adolescent↗
PubMed1993

[Evaluation of the reliability of endogenous creatinine clearance as in indicator of renal function in ambulatory patients. I].

Clearance of the endogenous creatinine is a simple method for application, it is relatively cheap and applicable in almost all surroundings, but it is not reliable enough when the obtained results are concerned. This report shows the results of determining this clearance in comparison with radiosotope clearance 51 cr-EDTA, referent for clinical research, in 52 outpatients with primary and secondary kidney diseases. It was found that values of clearance of the endogene creatinine (Clkr) are significantly lower than the clearance 51 Cr-EDTA (ClEDTA) (t = 2.391, p < 0.01) and that the correlation between the two method is poor (r = 0.688). The source of mistakes should be looked for (and strictly controlled) when gathering diuresis, because the biochemical method of creatnine concentration determination of the biologic material itself is reliable enough.

Adult↗
PubMed1993

Short-term effects of captopril (Katopil) on renal haemodynamics and function in hypertensive patients.

Short-term effects of captopril on the renal-hemodynamics and function were evaluated in 75 adult hypertensive patients. The behaviour of total and divided effective renal plasma flows (ERPF) and parenchymal mean transit time (PaMTT) implied three types of effect the premedication exerted on local renal haemodynamics and function: a protective one, no significant changes and an adverse one. In the vast majority of the cases captopril induced reduction in systemic blood pressure, was observed, irrespective of the renal response. The methodology presented seems to be a sensitive test for the selection of patients in whom an overall beneficial effect from the therapy with captopril monotherapy is expected.

Adult↗
PubMed1990

[Use of radioisotopes in urology].

The use of radionuclide methods in the functional investigation of the urinary tract has become a routine part in the diagnostics of nephro-urologic diseases. These methods provide a great deal of important additional information concerning the functional status of the kidney and renal outlet system such as: overall renal function, contribution of the individual kidney to global renal function, regional distribution of functionally viable renal tissue within the kidney, and the state of upper as well as lower urinary tract urodynamics. These functional parameters are complementary to the anatomic details of the urinary tract status, and are best depicted by radiologic techniques. The paper deals with the basic principles of certain radionuclide studies, their advantages and drawbacks, as well as the main areas of their clinical application.

Humans↗
PubMed1988

The effect of radiopharmaceutical choice on the assessment of the relative renal function in upper urinary tract obstruction.

The relative function of the obstructed kidney (RFOK) was assessed in 43 adult patients with upper urinary tract obstruction (UUTO) using 99mTc-DTPA and 131I-ortho-iodohippurate (OIH) dynamic studies and 99mTc-DMSA dynamic and static studies. The patients were divided into five groups according to the duration and degree of obstruction. Findings were as follows: a) in patients with the first occurrence of acute severe obstruction (group 1), the relative glomerular filtration rate (GFR) was significantly less than the relative effective renal plasma flow (ERPF); b) in patients with chronic severe obstruction and long term uroinfection, the relative ERPF decreased significantly compared with the relative GFR; c) the RFOK calculated from the DMSA dynamic study was the same as both the relative GFR or ERPF in any group; d) the RFOK calculated from the DMSA static study seemed to parallel the relative ERPF more closely than the relative GFR, but in group one it was significantly higher than any of three other estimates. It is concluded that 99mTc-DTPA is the radiopharmaceutical of choice in obstructive uronephropathy, but when interpreting the RFOK, the time course and severity of obstruction, the presence or absence of uroinfection should also be considered.

Adult↗
PubMed1988

Extravascular background subtraction using deconvolution analysis of the renogram.

The effect of the intravascular background in the renogram on the calculated renal retention function is known and can be removed. However, the effect of the extravascular background (EVB) has not been thoroughly investigated using patient data. By varying the size of the region of interest containing a single kidney and by deconvolving the 131I-hippuran and 99Tcm-DTPA renograms so generated, the following has been found: (a) the effect of EVB on the mean transit time (MTT) is negligible and EVB subtraction is not necessary, (b) the EVB overestimates the lower relative kidney function (RKF) and underestimates the higher RKF, so that EVB subtraction should be performed if the RKFs are asymmetric. A new method is described in which the correction for EVB is performed following deconvolution. If the RKFs are greater than about 30%, the correction can be performed using a regression equation between the RKFs corrected for EVB and those that are not corrected. When the RKFs are asymmetric to a greater extent, the correction should be performed for each study separately. The proposed method includes a small systematic error due to the inherent limitations of nuclear medicine equipment.

Adult↗