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V Seiberth

Publications and source records attributed to V Seiberth.

At least 37 records · Page 2Linked to original sources
PubMed1995

Diode laser photocoagulation for threshold retinopathy of prematurity in eyes with tunica vasculosa lentis.

PURPOSE: To determine possible side effects of diode laser photocoagulation for threshold retinopathy of prematurity in eyes with tunica vasculosa lentis. METHODS: In a prospective clinical study, threshold retinopathy of prematurity was treated in 14 eyes of seven consecutive preterm infants with tunica vasculosa lentis (birth weight, 480 to 980 g; mean +/- S.D., 777 +/- 175 g; gestational age, 24 to 27 weeks; mean +/- S.D., 25.7 +/- 0.9 weeks) by using the diode laser indirect ophthalmoscope. Main outcome measure was the incidence of adverse treatment effects. Follow-up included anterior segment examination with a hand-held slit lamp and ranged from seven to 17 months (12.6 +/- 3.5 months). RESULTS: The tunica vasculosa lentis did not interfere with photocoagulation in any of the 14 eyes. Laser power ranged from 200 to 400 mW (260 +/- 52 mW). Duration of a single spot was 200 msec. Number of burns ranged from 1,060 to 2,132 (1,556 +/- 315). Retinopathy of prematurity regressed in all eyes, and the outcome was a flat, attached retina. A small amount of postoperative anterior chamber bleeding was noticed in one eye (7% of the eyes, 14% of the patients). There were neither lenticular opacities nor cataract formation. CONCLUSION: Diode laser photocoagulation with the laser indirect ophthalmoscope can be used safely in eyes with tunica vasculosa lentis. At the laser energy levels used in our study, no transient lens opacities or cataract formation occurred. However, the results of this study are limited by a relatively small number of patients and a relatively short follow-up.

Capillaries↗
PubMed1994

A controlled clinical trial of light and retinopathy of prematurity.

Bright continuous light has been implicated in the pathogenesis of retinopathy of prematurity. To investigate the influence of light on the incidence and severity of retinopathy of prematurity, we enrolled 127 preterm infants (birth weight < or = 1,500 g; gestational age < or = 32 weeks) in a controlled clinical study. Randomization was done separately for three birth-weight groups (< 1,000 g; 1,000 to 1,249 g; 1,250 to 1,500 g). The babies' eyes were patched all day and night from birth to a gestational age of 35 weeks. The infants in the control group were exposed to cycled lighting conditions (that is, reduced light level during the night). Of 62 infants with patched eyes, 26 (42%) developed retinopathy of prematurity. In the control group, 25 of 65 infants (39%) showed retinopathy of prematurity (P = .596). There were also no statistically significant differences in the incidences of retinopathy of prematurity in the birth-weight subgroups or in the severity of retinopathy of prematurity. Thus, patching of the eyes from birth to 35 weeks of postconceptional age does not decrease the risk of retinopathy of prematurity in preterm infants when compared to a control group exposed to cycled lighting conditions.

Female↗
PubMed1994

[Ocular findings in former premature infants at the age of 11 to 14 years].

BACKGROUND: Functional disturbances as well as morphologic changes can be various in regressed retinopathy of prematurity (ROP). PATIENTS AND METHODS: To investigate the incidence and the degree of such changes, we examined prematurely born infants in the age of 11 to 14 years. Of the 142 prematures (birthweight < or = 2000 g), who were cared for in their first weeks of life in the University Children's Hospital at the Klinikum Mannheim in 1977 to 1979, 48 could be reexamined. RESULTS: Of 48 infants (mean birth weight 1808 +/- 211 g, gestational age 34.6 +/- 3.1 weeks) six (12.5%; birth weight 1742 +/- 218 g, gestational age 32.2 +/- 2.5) had had acute ROP (stage 2 or 3). When reexamined in school age 10 (21%) of the children had physical deficits. Eight (17%) visited a school for handicapped children. Eight (17%) children had a squint. In 13 out of 96 (14%) eyes visual acuity was reduced to 0.8 or less. Thirteen eyes (14%) were emmetropic, 67 (70%) hyperopic, 16 (17%) myopic and 15 (16%) astigmatic. The intraocular pressure was normal in all eyes (15 +/- 4 mm Hg). The anterior segments did not show findings caused by ROP. The fundus findings in the 12 eyes, in which the diagnosis of acute ROP was established in the first weeks of life, showed in 5 (42%) eyes a slightly reduced angle kappa between the vascular arcades and avascular retina in the temporal fundus periphery in all of the 12 (100%) eyes. In 1 (8%) eye the retinal periphery showed extensive scarring after cryotherapy because of acute ROP. None of the eyes which had had acute ROP showed macular ectopia or retinal folds (amotio falciformis). In 16 of the 84 (19%) eyes, which did not have a history of acute ROP, minor changes of the retinal periphery, the peripheral retinal vessels and the pigment epithelium were present, which were caused by prematurity. CONCLUSION: Prematurely born infants examined in school age, who were comparatively mature preterms at birth (mean birth weight 1800 g; mean gestational age 34.6 weeks), did not show a higher risk of refractive errors, i.e. myopia. However, they were at higher risk having squint. The functional disturbances found in the prematurely born infants in this study were not caused by morphologic changes due to ROP.

Adolescent↗
PubMed1994

[Eye manifestations of shaken baby syndrome. A case presentation].

UNLABELLED: Violent shaking is a type of child abuse which may cause intracranial hemorrhages combined with retinal and vitreous bleeding. Fundus bleeding is similar to that in Terson syndrome. However, in the shaken baby syndrome the intraocular hemorrhages may precede both the clinical and radiologic recognition of subdural haematoma. CASE REPORT: We present a 4-months-old baby with convulsions and additional extensive bleeding of the fundus. Neither the ocular findings nor the seizures could be explained by minimal lesions of external trauma. Repeated cranial computed tomography showed increasing intracerebral bleeding with consecutive brain atrophy. Fundus bleeding completely disappeared. CONCLUSION: When child abuse is suspected, ophthalmological examination is most important to detect fundus bleeding, which, in the absence of birth trauma or any other supportive evidence of external trauma or other diseases, is the leading symptom of the shaken baby syndrome.

Battered Child Syndrome↗
PubMed1993

Panretinal photocoagulation in diabetic retinopathy: argon versus dye laser coagulation.

The range of wavelengths used in ophthalmic photocoagulation treatment has been greatly enlarged by the development of the dye laser. To investigate the efficacy and possible side effects of orange dye laser light in the treatment of diabetic retinopathy, we performed a prospective, controlled clinical study comparing argon blue-green and orange dye laser light. In 14 patients with diabetic retinopathy of equal severity in both eyes one eye was randomly assigned to either blue-green argon (488 and 514.5 nm) or orange dye (600 nm) panretinal laser treatment. The total coagulated area was the same in both eyes. Subjective parameters (visual acuity, perimetry, color vision) as well as objective functions (electroretinography, electro-oculography) and the clinical course were studied preoperatively and then postoperatively over a period of 6 months. Dye laser coagulation proved as effective and safe as blue-green argon laser coagulation in the panretinal treatment of diabetic retinopathy. No significant differences in postoperative retinal function were detected. However, orange laser coagulation proved significantly more painful than blue-green argon laser treatment (P = 0.002).

Adult↗
PubMed1993

Comparison of the optical and visual quality of poly(methyl methacrylate) and silicone intraocular lenses.

We evaluated experimentally the optical quality of poly(methyl methacrylate) (PMMA) (Storz 68UV, AMO PC58) and silicone (AMO SI19, Adatomed 90D) intraocular lenses (IOLs) and compared the results with our clinical data. We measured surface and image quality using the Zygo laser interferometer and modulation transfer function (MTF) using the Ealing EROS MTF analyzer. Contrast acuity was tested clinically with glare and without glare (Regan charts); AMO PC58, n = 18; AMO SI19, n = 7; Adatomed 90D, n = 18). Modulation transfer function and image quality were slightly better with PMMA IOLs but the reduction of MTF with silicone lenses was within the 1/8 diopter defocus range. Surface quality of silicone IOLs was superior to that of PMMA IOLs. Contrast acuity measured clinically was also slightly better with PMMA IOLs at low contrast and with glare but differences were not significant. Our results suggest that optical and visual quality of silicone IOLs is slightly lower than with PMMA IOLs. Experimental and clinical results correlated closely. However, the small differences observed are unlikely to be significant clinically.

Aged↗
PubMed1993

Evaluation of contrast acuity and defocus curve in bifocal and monofocal intraocular lenses.

We compared visual quality of the following intraocular lenses in a prospective study: monofocal, True Vista bifocal, 3M diffractive bifocal, and Nordan aspheric VariFocal silicone. Four to six months postoperatively we measured distance acuity, Snellen near acuity (Lighthouse chart), reading acuity (Nieden chart), and contrast acuity at far and near focus (Regan charts: 96%, 50%, 25%, 11% contrast) with different pupil sizes. A defocus curve was obtained by spectacle defocus (+1 diopter [D] to -5 D). Eleven patients had True Vista in one eye and monofocal in the fellow. Contrast acuity at far focus decreased with decreasing contrast and increasing pupil size. This decrease was more pronounced with the True Vista than with the monofocal lenses. These differences were significant, with a 4.5 mm pupil at lower contrast (25%, P = .02; 11%, P = .01). Depth of focus was 4.5 D (+1.0 D to -2.0 D) with True Vista lenses and 2.5 D (+1.0 D to -1.5 D) with monofocal lenses. Corrected distance acuity was 20/22 with True Vista, 20/25 with 3M, and 20/20 with VariFocal. Distance corrected Snellen near acuity was 20/39 with True Vista, 20/34 with 3M, and 20/57 with VariFocal. Distance corrected reading acuity was 20/29 with True Vista, 20/23 with 3M, and 20/44 with VariFocal (P = .005). Contrast acuity at far focus was best with the VariFocal IOL, followed by True Vista and 3M. At near focus it was best with 3M, followed by True Vista and VariFocal. Contrast acuity at near focus was lower than at far focus. Average acuity differences were as follows: VariFocal 0.43, P = .01; True Vista 0.19, P = .05; 3M 0.04, P = .3. Depth of focus was 4.5 D (+1.0 D to -3.5 D) with True Vista and 3M and was 3 D (+1.0 D to -2.0 D) with VariFocal. Each design offers unique features. VariFocal is best at distance, but near vision is not sufficient. The 3M lens is best at near vision but distance contrast acuity is somewhat reduced. The True Vista lens provides a good compromise as distance contrast acuity is good and near vision is sufficient.

Aged↗
PubMed1993

[Contrast sensitivity and defocus curve with various bifocal-IOL].

Simultaneous vision, the basic principle of all bifocal intraocular lenses (IOLs), provides increased depth of focus but also causes a loss in contrast. We therefore measured contrast acuity (CA) (Regan Charts) and the defocus curve at different pupil sizes in 14 patients with a TRUE VISTA bifocal IOL (TV) (Storz Co.), 10 patients with a 3M diffractive bifocal IOL (3M) (3M Co.) and 9 patients with a Nordan Aspheric Varifocal Silicone IOL (VF) (Wright Medical Inc.). CA at distance focus was best with VF; next was TV, and 3M showed the lowest values. At near focus, CA was best with 3M; next was TV, and VF showed the lowest values. Differences between VF and 3M were significant (P = 0.05; t-test). CA at near focus was significantly lower than at distance focus with TV and VF (TV: P = 0.0001; VF: P = 0.005). Pseudoaccommodation was 4.5 D with TV and 3M and 3D with VF. In conclusion, distance CA was best with VF but pseudoaccommodation was not sufficient for reading. Near CA was best with 3M while distance CA was somewhat reduced. TV showed good distance CA while near CA was still sufficient. TV therefore seems to provide a good compromise.

Accommodation, Ocular↗
PubMed1992

Comparison of modulation transfer function and through focus response with monofocal and bifocal IOLs.

We analyzed modulation transfer function (MTF) and through focus response (TFR) of the TRUE VISTA bifocal IOL and monofocal IOLs and compared the experimental and clinical data. MTF and TFR were measured at different pupil sizes (2, 3, 4 mm), base powers (14, 21, 27 D), add powers (2, 3, 4 D), and distance zone diameters (1.25, 1.5, 1.75 mm). Standards were established to correlate MTF and contrast sensitivity, as well as TFR and the defocus curve measured clinically. MTF of TRUE VISTA decreased with increasing pupil size and base power. A near add of 4 D showed the best MTF at distant and near focus. MTF of TRUE VISTA at near focus was lower than at distant focus and MTF at distant focus was lower than MTF of monofocal IOLs. TFR and the defocus curve correlated closely. MTF and contrast sensitivity of TRUE VISTA at far and near focus also correlated closely. MTF and contrast sensitivity of monofocal IOLs and TRUE VISTA at distant focus did not correlate. MTF was considerably better with monofocal IOLs while contrast sensitivity was slightly better only at low contrast. However, MTF of monofocal IOLs was much higher than MTF of a normal eye while MTF of TRUE VISTA at distant focus was only slightly lower than the MTF of a normal eye. Using MTF of a normal eye as a threshold, our results demonstrated a close correlation between experimental and clinical findings. MTF and TFR may therefore reliably predict the performance of bifocal IOLs.

Contrast Sensitivity↗
PubMed1991

Function of the diabetic retina after panretinal argon laser photocoagulation. Influence of the intensity of the coagulation spots.

To investigate the influence of the intensity of coagulation spots on retinal function and the clinical course after panretinal argon laser photocoagulation in diabetic retinopathy, we conducted a prospective study in 24 eyes of 12 diabetics. One eye was treated with moderate spots (average: 300 mW), the fellow eye was coagulated with intense spots (average: 600 mW). The spot size was identical in both eyes. Subjective parameters (visual acuity, perimetry), as well as objective functions (ERG, EOG) and the clinical course, were studied preoperatively and on a regular base with a follow-up of 12 months. Visual acuity and fundus findings deteriorated less often in eyes coagulated with intense spots. Visual field loss, however, was more prevalent in eyes treated with intense spots. Early treatment complications only occurred with high-energy coagulation. For this reason, high-energy spots should not be used even though they might be indicated theoretically.

Adult↗
PubMed1991

[Amyloidosis of the vitreous body. Possibilities of diagnosis].

Vitreous amyloidosis is often the presenting clinical manifestation of type I, type II or Jewish-type familial amyloid polyneuropathy (FAP). FAP is an autosomal dominant inherited disorder. It is caused by systemic deposition of variants of transthyretin (TTR), formerly called prealbumin. TTR is a tetrameric protein with beta pleated sheets (mol wt = 56,000 dalton). In two cases we were able to confirm the clinical diagnosis of vitreous amyloidosis. Immunohistochemistry revealed TTR in vitreous samples after therapeutic pp vitrectomy for vitreous opacity. The same result was found in samples of rectal mucosa. Amyloid was not found in skin. Isoelectrical focusing disclosed that TTR in the serum was the Portuguese (TTR-Met 30) variant. Together with polyneuropathy of the lower limbs, a diagnosis of FAB type I was made. In the second generation of the first patient's family the normal variant was found (the pathologic gene was not inherited). In the second case the pathologic variant was detected in the second generation, but without any pathologic clinical features. The third generation showed the normal variant. The disorder was detectable before any clinical signs were present. These findings are also important for genetic counseling.

Aged↗
PubMed1991

Incidence of posterior capsule opacification after extracapsular cataract extraction in diabetic patients.

Posterior capsule opacification (PCO) is the most frequent complication following extracapsular cataract extraction (ECCE). To evaluate the rate of PCO we examined 939 eyes (786 patients) following ECCE after a period of 26.3 months on the average. In 202 eyes (21.5%) cataract was associated with a clinically manifest type I or type II diabetes mellitus. The overall incidence of PCO was 28.1% (264 eyes). In patients with no other diseases (371 eyes, 100%) it was 33.4% (124 eyes). Out of 202 eyes (100%) associated with diabetes PCO was seen in 21.8% (44 eyes). This difference was statistically significant (p = 0.05). Average age and sex did not differ significantly in both groups. In diabetic patients the lens epithelial cells show accumulation of sorbitol and fructose which is proposed to contribute to cataract formation by disturbing cellular metabolism. This mechanism may explain our findings of a lower incidence of PCO possibly caused by reduced proliferation of lens epithelial cells.

Cataract↗
PubMed1991

[Retinopathy of prematurity: why are girls more frequently affected?].

In 226 prematures (birth weight less than or equal to 1500 g), who were examined prospectively between 1986 and 1988, retinopathy of prematurity occurred significantly more often in girls: 31.0% of the eyes of 134 girls and 22.3% of the eyes of 92 boys showed retinopathy of prematurity (p = 0.042). Different factors may influence the sex ratio of retinopathy of prematurity: (1) hormonal differences are already present shortly after birth; (2) there are different ventilation rates in girls and boys; (3) the mortality varies between girls and boys. The influence of mortality was demonstrated in the group of preterms examined: in this time period, 59 of 285 prematures died: 21 of 155 girls (13.5%) and 38 of 130 boys (29.2%). Significantly more boys than girls died (p = 0.001). For this reason the percentage of surviving girls at high risk of having retinopathy is high. The apparently greater prevalence in girls is the result.

Cross-Sectional Studies↗
PubMed1990

Refractive errors after cryotherapy in retinopathy of prematurity.

Because of acute retinopathy of prematurity 14 premature infants (900-1,630 g birth weight) were treated with cryocoagulation (10 children, both eyes; 4 only one eye) between 1976 and 1984 and were followed up until they were 2-7 years of age. The average refractive power of 20 eyes (those in which refraction could be determined) was -1.5 +/- 4.1 dptr. Twelve eyes (60.0%) were hyperopic (average: +1.3 +/- 0.4 dptr), and 8 eyes (40.0%) were myopic (average: -5.7 +/- 3.6 dptr). Three eyes in which cryocoagulation was done twice or three times because of a severe course developed pronounced myopia (greater than 7.0 dptr). When comparing both eyes of 4 children in whom cryotherapy had been carried out in only one eye, cryotherapy was found to have no influence on refractive errors (average anisometropia +0.4 +/- 0.4 dptr).

Birth Weight↗
PubMed1990

[Therapy of central serous detachment in papillary coloboma. A case report].

A central retinal detachment caused by coloboma of the optic nerve head in one eye of a 34-year-old Caucasian male was treated successfully by pars-plana vitrectomy, endodiathermy of the hole situated at the periphery of the optic nerve head, drainage of the subretinal fluid and injection of silicone oil into the vitreous cavity. After removal of the silicone oil, the retina was still attached and the retinal function was unchanged. The clinical course is described.

Adult↗
PubMed1990

[Loss of corneal endothelial cells following pars plana vitrectomy and silicone oil implantation].

Endothelial cell loss contributes to severe corneal decompensation following pars plana vitrectomy and silicone oil injection into the vitreous cavity. The corneal endothelium of 35 eyes (35 patients) was evaluated prospectively before and after pars plana vitrectomy in a clinical study by means of wide field specular microscopy (Roberts and Koester). Special attention was paid to differences between patients with and without silicone oil in the anterior chamber with respect to postoperative complications and endothelial cell loss. In 12 of the 35 eyes silicone oil was present in the anterior chamber. After a 6-month follow-up we found in all 35 eyes an average decrease in endothelial cell density of 22.9% +/- 13.3% compared to the preoperative values. A correlation between pre- and postoperative cell density (r = 0.827) after six months could be demonstrated. Logistic regression was used to estimate the statistical significance of various factors influencing endothelial cell loss such as inflammatory anterior chamber reaction, elevated intraocular pressure and silicone oil in the anterior chamber. Silicone oil in the anterior chamber was proved to be the main factor causing endothelial cell loss (p less than 0.025). Age group and number of previous intraocular surgical procedures showed no significant influence on endothelial cell loss.

Adult↗
PubMed1989

[Acute retinopathy of prematurity: shift of the manifestation risk to extremely premature infants by neonatal intensive care medicine].

A total of 381 surviving prematures (birthweight less than or equal to 2500 g) at the heidelberg University Children's Hospital were examined ophthalmologically between January 1986 and June 1988. Of the 762 eyes, 112 (14.7%) showed acute retinopathy of prematurity (ROP). In our study, a correlation between birthweight, gestational age and retinopathy of prematurity was confirmed. In addition, the results concerning severity, differences between the right and left eye, and the incidence in twins and multiple births were demonstrated. Data were compared with the data in 29 papers dealing with the prevalence of acute ROP since 1968: 12,468 preterm infants were investigated in all papers; 2,087 of these infants (16.7%) showed ROP. In the literature, 8.4% of the premature babies with a birthweight of 1501 to 2500 g were found to have ROP. In our group with the same birthweight, only one baby (birthweight 1510 g) had retinopathy (0.6%). The fact that the average ROP prevalence has not changed significantly indicates that the risk of having retinopathy of prematurity has switched over to the more immature preterms, whose prognosis of survival has improved in the last few years as a result of the improvement in neonatal care.

Female↗