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Biomedical subjects

V Sergeev

Publications and source records attributed to V Sergeev.

2 recordsLinked to original sources

Some characteristics of new DNA-bearing plasmoimmunoadsorbents based on fibrous activated carbon.

A new dual adsorbent containing from 1 to 8 mg of native or denatured thymic DNA per 1 g of the fibrous activated carbon matrix has demonstrated sufficient biocompatibility and good selectivity for DNA-binding plasma substances. At the same time, this dual adsorbent exhibits a full scale of coupling modalities characteristic of the highest quality activated carbons. All these features of DNA-coated fibrous activated carbons allow them to be considered as promising plasmosorbents for the treatment of numerous immuno-dependent diseases and metabolic disorders.

Biocompatible Materials↗

Biologically modified PHEMA beads for hemoperfusion: preliminary studies.

Polyhydroxyethylmethacrylate (PHEMA) beads were prepared by phase separation polymerization. Hydroxyl groups on PHEMA beads were activated with CNBr at alkaline pH. Adsorption of heparin, blood proteins (i.e. albumin, fibrinogen and gamma-globulin), protein A, HIgG and DNA on these beads were studied. Preparation and activation procedures are given here. The preliminary results of these studies are also reported.

Adsorption↗