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PubMed1976

Attempt to induce cataracts in rabbits by cutaneous application of acetone.

Acetone is used as a solvent for chemicals in skin sensitization studies. Its low cost, high solvent powers, and comparative lack of toxicity make it one of the most widely used industrial solvents. Absorption of acetone through the skin is not considered hazardous; however, in an earlier study we found that acetone caused cataracts in a large group of guinea pigs when small multiple doses were administered either topically or intracutaneously on the backs of these animals. No cataracts were found when two rabbits were tested. The purpose of the present study is to repeat the earlier study using more rabbits. Here, none of the 10 experimental rabbits or the 10 control rabbits developed any lens abnormalities. Those drugs and toxic substances that have produced cataracts in rabbits are described.

Acetone↗

PubMedDate not supplied

Evaluating elderly patients with syncope.

Age-related physiologic changes together with high prevalence of chronic illness and the use of multiple medications predispose older adults to syncope. The causes of many of these patients' syncope are unexplained and most remained symptomatic. A thoughtful diagnostic strategy is essential to pinpoint the cause in each patient. The initial assessment includes a comprehensive medical history, preferably with an eye witness account, and a thorough physical examination. The decision for further diagnostic tests often depends on whether there is evidence of underlying structural heart disease. In the absence of heart disease, tilt table testing and the related autonomic function testing are usually most productive. Various cardiac studies will be more appropriate for those with suspected structural heart disease. A cause of syncope can only be concluded if there is a sufficiently strong correlation between syncopal symptoms and the detected abnormalities on investigations. A strategic evaluation of syncope of the elderly subjects should allow a correct diagnosis and appropriate management.

Journal Article↗