Biotransformation of demecolcine by rat liver microsomes.
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Animals↗
Biomedical subjects
V Simánek
Publications and source records attributed to V Simánek.
Determination of beta-phenylalkylamines in pharmaceutical preparations by analytical capillary isotachophoresis.
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Chemical Phenomena↗
Comparison of biological activity of some benzo (c)-phenanthridine alkaloids and their structural analogs.
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Alkaloids↗
Determination of papaverine by capillary isotachophoresis.
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Drug Combinations↗
Relationships between chemical structures and antimitotic activities of a group of colchicine alkaloids.
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Animals↗
Practical application of isotachophoresis in analysis of isoquinoline alkaloids.
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Chemical Phenomena↗
Molecular mechanisms of the biological activity of quaternary benzophenanthridine and protoberberine alkaloids.
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Alkaloids↗
Isoquinoline alkaloids in local periodontal disease therapy (preliminary notice).
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Alkaloids↗
Inhibition of acetylcholinesterase activity by some isoquinoline alkaloids.
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Animals↗
Selective determination of a cyclohexylamine concentration in the presence of other bases.
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Chemistry, Organic↗
Isolation and identification of alkaloids of the subfamily Wurmbaeoideae.
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Alkaloids↗
Inhibition of butyrylcholinesterase activity by some isoquinoline alkaloids.
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Alkaloids↗
Applications of hydroxyl proton chemical shifts of methyl substituted phenols as electronic and steric parameters in QSAR studies.
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Chemical Phenomena↗
Determination of antioxidants of the diphenylamine type in butadiene-styrene rubber (BSR).
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Antioxidants↗
Applications of hydroxyl proton chemical shifts of methyl substituted phenols as electronic and steric parameters in QSAR studies.
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Magnetic Resonance Spectroscopy↗
Inhibition of liver alanine aminotransferase activity by some benzophenanthridine alkaloids.
The quaternary benzophenanthridine alkaloids sanguinarine (1) and chelerythrine (2) inhibit rat liver L-alanine-:2-oxoglutarate aminotransferase (EC 2.6.1.2) activity. Nitidine (3) has no inhibitory effect. The inhibitory activity of alkaloids depends on the reactivity of the iminium bond with the nucleophilic reagent, e.g., the thiol group. The stability constants of adduct formation for thioethanol, cysteine, and glutathione with sanguinarine (1) and chelerythrine (2) are given. The mechanism of the inhibition of alanine aminotransferase activity by the alkaloids 1 and 2 is discussed.
Alanine Transaminase↗
Antiinflammatory activity of quaternary benzophenanthridine alkaloids from Chelidonium majus.
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Alkaloids↗
[Estimation of the lipophility of phenols using separation thin layer chromatography. Comments on Biagi's method].
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Chromatography, Thin Layer↗